Summary
基因 10776
象征 Arpp19
Synonyms arpp-16 | arpp-19 | arpp16 | insal
Description cAMP调节磷蛋白19KDA
Reference MIM:605487|HGNC:HGNC:16967|Ensembl:ENSG00000128989|HPRD:09264|Vega:Otthumg00000172677
基因类型 蛋白质编码
地图中心tion 15Q21.2
Pascal P值 1.375E-4
Sherlock p-value 0.537
DEG P值 DEG:Maycox_2009:cc_ba10_fold_change = -1.12:cc_ba10_disease_p = 0.0041:hbb_ba9_fold_change = -1.20:hbb_ba9_disease_p = 0.0030
胎儿β -1.447
DMG 1 (# studies)
主持人 小脑
Hypothalamus

Gene in Data Sources
基因集名称 Method of gene set Description 信息
简历:PGCNP 全基因组协会研究 GWAS
DEG:Maycox_2009 Microarray to determine the expression of over 30000 mRNA transcripts in post-mortem tissue 我们包括了51个基因,其表达变化在两个精神分裂症队列之间很常见。
DMG:JAFFE_2016 全基因组DNA甲基化分析 该数据集包括与SZ患者相关的2,104个探针/CPG(n = 108),而在Bonferroni调整后的P <0.05时,其中136个对照。 2

Section I. Genetics and epigenetics annotation

@差异甲基化基因

探针 染色体 位置 最近的基因 p(dis) Beta (dis) fdr(dis) 学习
CG03799220 15 52860635 Arpp19 2.4E-8 -0.03 7.84e-6 DMG:JAFFE_2016
CG23865067 15 52860622 Arpp19 7.07e-8 -0.015 1.7e-5 DMG:JAFFE_2016


第二节。转录组注释

一般基因表达(GTEX)

无法使用

Devlopment期间的基因表达(BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达(brainspan)

Footnote:
SC:亚皮质区域;SM:感觉运动区域;FC:额叶皮层;和TP:颞顶皮层
ST1:胎儿(13-26个概念后周),ST2:婴儿早期至童年(4个月至11年)和ST3:青春期至成年期(13-23年)
所示的栏表示表达分布的较低25%和上层25%。

No co-expressed genes in brain regions


第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
去:0005102 受体结合 艾达 神经递质(GO期限:4) 9653196
GO:0015459 钾通道调节剂活性 艾达 9653196
生物过程 去学期 证据 神经关键字 PubMed ID
GO:0045722 positive regulation of gluconeogenesis 艾达 9653196
GO:0046326 葡萄糖进口的积极调节 nas 9653196
Cellular component 去学期 证据 神经关键字 PubMed ID
去:0005737 cytoplasm IEA -

Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
通过CD40 UP的Hollmann凋亡 201 125 All SZGR 2.0 genes in this pathway
Davicioni分子臂与ERMS 332 228 All SZGR 2.0 genes in this pathway
迪亚兹慢性巨态性白血病 1382 904 All SZGR 2.0 genes in this pathway
LAIHO大肠癌锯齿状的 112 71 All SZGR 2.0 genes in this pathway
奥斯曼膀胱癌DN 406 230 All SZGR 2.0 genes in this pathway
Bidus转移 214 134 All SZGR 2.0 genes in this pathway
多德鼻咽癌DN 1375 806 All SZGR 2.0 genes in this pathway
hahtola兄弟姐妹Fungoides皮肤 177 113 All SZGR 2.0 genes in this pathway
pDGFB DN的Johansson神经胶质作用 21 16 All SZGR 2.0 genes in this pathway
通过ELK3 UP总缺氧 209 139 All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN 848 527 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024 594 All SZGR 2.0 genes in this pathway
buytaert光动力疗法压力 811 508 All SZGR 2.0 genes in this pathway
WEI mir34a目标 148 97 All SZGR 2.0 genes in this pathway
Benporath Myc Max目标 775 494 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 All SZGR 2.0 genes in this pathway
葡萄病毒感染的Debiasi凋亡 314 201 All SZGR 2.0 genes in this pathway
阿尔茨海默氏病dn 1237 837 All SZGR 2.0 genes in this pathway
伊万诺娃造血细胞和祖细胞 681 420 All SZGR 2.0 genes in this pathway
RAMASWAMY METASTASIS UP 66 43 All SZGR 2.0 genes in this pathway
江口大脑皮层DN 54 43 All SZGR 2.0 genes in this pathway
马丁内斯RB1靶向 673 430 All SZGR 2.0 genes in this pathway
Martinez TP53靶向 602 364 All SZGR 2.0 genes in this pathway
Martinez RB1和TP53靶向 601 369 All SZGR 2.0 genes in this pathway
阿塞维多肝癌 973 570 All SZGR 2.0 genes in this pathway
阿塞维多肝肿瘤与正常的相邻组织向上 863 514 All SZGR 2.0 genes in this pathway
张乳腺癌祖细胞 425 253 All SZGR 2.0 genes in this pathway
对Salirasib dn的Blum响应 342 220 All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP 374 247 All SZGR 2.0 genes in this pathway
Shedden肺癌的生存率差A6 456 285 All SZGR 2.0 genes in this pathway
张TLX目标36小时DN 185 116 All SZGR 2.0 genes in this pathway
米利假足 518 299 All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP 442 263 All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G3 UP 188 121 All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT UP 166 105 All SZGR 2.0 genes in this pathway
由MYC约束 1103 714 All SZGR 2.0 genes in this pathway
Kim所有疾病Calb1 Corr Up 548 370 All SZGR 2.0 genes in this pathway
Pilon KLF1靶向DN 1972 1213 All SZGR 2.0 genes in this pathway
Johnstone Parvb目标2 DN 336 211 All SZGR 2.0 genes in this pathway
Fortschegger PHF8靶向DN 784 464 All SZGR 2.0 genes in this pathway
FOSTER KDM1A TARGETS DN 211 119 All SZGR 2.0 genes in this pathway
巨噬细胞的库马尔病原体负荷 275 155 All SZGR 2.0 genes in this pathway
Kumar自噬网络 71 46 All SZGR 2.0 genes in this pathway
Zwang 1类由EGF瞬时诱导 516 308 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族 目标位置 miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
Let-7/98 2259 2266 1A,M8 hsa-let-7abrain ugagguaguaguauauaguu
hsa-let-7bbrain ugagguaguagguuguguguguu
hsa-let-7cbrain ugagguaguagguuguaugguu
hsa-let-7dbrain AGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrain ugagguaggagguuauauagu
hsa-let-7fbrain ugagguagauuguauauaguu
HSA-MIR-98brain ugagguaaguuguauuguu
hsa-let-7gSZ ugagguaguuguuguacagu
hsa-let-7ibrain ugagguaguugugugugugcugu
mir-124.1 514 520 1a HSA-MIR-124A UUAAGGCACGCGGUGAAUGCCA
mir-148/152 180 186 M8 HSA-MIR-148A ucagugcacuacaacuuugu
HSA-MIR-152brain UCAGUGCAUGACACUUGGG
HSA-MIR-148B ucagugcaucacacaacuuugu
miR-153 1007 1013 M8 HSA-MIR-153 UUGCAUAGUCACAAAAGUGA
miR-183 708 714 M8 HSA-MIR-183 uauggcacugguagaauucacug
mir-19 733 740 1A,M8 HSA-MIR-19A ugugcaaauaugauaugaaaacuga
HSA-MIR-19B UGUGCAAAUCCAUGCAAAACUGA
mir-218 802 809 1A,M8 hsa-miR-218brain UUGUGCUUGAUCUAACCAUGU
mir-23 663 669 1a HSA-MIR-23Abrain AUCACAUUGCCAGGGAUUUCC
HSA-MIR-23Bbrain aucacauugccagggauuacc
mir-26 2995 3001 M8 HSA-MIR-26Abrain UUCAAGUAAUCCAGGAUAGGC
HSA-MIR-26BSZ UUCAAGUAAUUCAGGAUAGGUU
mir-27 2282 2288 1a HSA-MIR-27Abrain uucacaguggcuaaguuccgc
HSA-MIR-27Bbrain uucacaguggcuaaguucugc
mir-29 2458 2464 M8 HSA-MIR-29ASZ uagcaccaucugaaaucgguu
HSA-MIR-29BSZ UAGCACCAUUUGAAAUCAGUGUU
HSA-MIR-29CSZ uagcaccauuugaaaucggu
mir-30-3p 893 899 M8 HSA-MIR-30A-3P CUUUCAGUCGGAUGUUUGCAGC
HSA-MIR-30E-3P cuuucagucggauguauacagc
mir-30-5p 863 869 1a HSA-MIR-30A-5P uguaaaacauccuccugagaag
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ uguaaacauccuaccucucagcu
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
mir-320 529 536 1A,M8 hsa-miR-320 aaaagcugggugagaggggcgaa
hsa-miR-320 aaaagcugggugagaggggcgaa
mir-410 1058 1064 1a hsa-miR-410 aauauaacacagauggcugu
mir-505 655 661 1a HSA-MIR-505 gucaacuugcugguuccuc
mir-539 39 45 M8 hsa-miR-539 GGAGAAAUUAUCCUUGGUGUGU
mir-544 1010 1016 M8 hsa-miR-544 auucugcauuuuuuagcaagu
hsa-miR-544 auucugcauuuuuuagcaagu
mir-96 791 797 M8 HSA-MIR-96brain uuuggcacuagcacauuuuugc