Gene Page:SLC17A3

Summary?
GeneID 10786
Symbol SLC17A3
Synonyms GOUT4|NPT4|UAQTL4
Description solute carrier family 17 member 3
Reference MIM:611034|HGNC:HGNC:10931|Ensembl:ENSG00000124564|HPRD:10233|Vega:OTTHUMG00000014412
Gene type protein-coding
Map location 6p21.3
Pascal p-value 1E-12
Fetal beta 0.026

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 系统ematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I Genome scan meta-analysis Psr: 0.033
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
YWHAE 0.93 0.92
PTGES3 0.92 0.89
EIF2S1 0.91 0.91
DNAJB6 0.91 0.91
DNAJC8 0.91 0.90
TAF7 0.91 0.90
GLOD4 0.90 0.88
YEATS4 0.90 0.90
DDX50 0.90 0.88
C16orf94 0.90 0.87
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MT-CO2 -0.71 -0.70
AF347015.2 -0.70 -0.71
MT-CYB -0.69 -0.70
AF347015.33 -0.69 -0.69
AF347015.31 -0.68 -0.70
AF347015.8 -0.68 -0.68
AF347015.15 -0.67 -0.70
AF347015.26 -0.67 -0.69
AF347015.9 -0.67 -0.72
AF347015.27 -0.65 -0.66

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005436 sodium:phosphate symporter activity TAS 9149941
GO:0005215 transporter activity IEA -
GO:0015293 symporter activity IEA -
GO:0031402 sodium ion binding IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006814 sodium ion transport TAS 9149941
GO:0006811 ion transport IEA -
GO:0006810 transport IEA -
GO:0006796 phosphate metabolic process TAS 9149941
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005789 endoplasmic reticulum membrane IEA -
GO:0005624 membrane fraction TAS 9149941
GO:0005783 endoplasmic reticulum IEA -
GO:0016020 membrane IEA -
GO:0016021 integral to membrane IEA -
GO:0005887 integral to plasma membrane TAS 9149941

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
LEE LIVER CANCER CIPROFIBRATE DN 66 43 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546 351 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555 346 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973 570 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863 514 All SZGR 2.0 genes in this pathway
阿塞维多甲基化在肝癌DN 940 425 All SZGR 2.0 genes in this pathway
OHGUCHI LIVER HNF4A TARGETS DN 149 85 All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS DN 157 105 All SZGR 2.0 genes in this pathway