Gene Page:LILRB1

Summary?
GeneID 10859
Symbol LILRB1
Synonyms CD85J|ILT-2|ILT2|LIR-1|LIR1|MIR-7|MIR7
Description leukocyte immunoglobulin like receptor B1
Reference MIM:604811|HGNC:HGNC:6605|Ensembl:ENSG00000104972|HPRD:07273|Vega:OTTHUMG00000065695
Gene type protein-coding
Map location 19q13.4
Pascal p-value 0.162
Fetal beta -0.425
DMG 1 (# studies)

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg01720520 19 55127892 LILRB1 5.431E-4 -0.272 0.048 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
COPZ1 0.89 0.86
MRPL3 0.88 0.87
RAN 0.88 0.84
TAF7 0.87 0.87
PTGES3 0.87 0.85
PSMD6 0.87 0.83
FAF1 0.87 0.84
FBXO22 0.87 0.83
ATG12 0.86 0.85
RAD1 0.86 0.83
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.8 -0.79 -0.77
MT-CO2 -0.77 -0.75
AF347015.15 -0.76 -0.77
AF347015.2 -0.75 -0.73
AF347015.33 -0.75 -0.74
MT-CYB -0.75 -0.75
AF347015.27 -0.74 -0.75
AF347015.26 -0.73 -0.73
AF347015.31 -0.72 -0.72
AF347015.21 -0.72 -0.70

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 70 37 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
REACTOME适应性免疫系统 539 350 All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP 423 283 All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL DN 244 153 All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP 404 246 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION ERYTHROCYTE UP 157 104 All SZGR 2.0 genes in this pathway
MATTIOLI MGUS VS PCL 116 62 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED UP 183 111 All SZGR 2.0 genes in this pathway
CROMER TUMORIGENESIS DN 51 29 All SZGR 2.0 genes in this pathway
DAVIES MULTIPLE MYELOMA VS MGUS DN 28 18 All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 5 33 24 All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER UP 288 168 All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA1 UP 76 46 All SZGR 2.0 genes in this pathway
BOSCO INTERFERON INDUCED ANTIVIRAL MODULE 78 48 All SZGR 2.0 genes in this pathway
KUMAR PATHOGEN LOAD BY MACROPHAGES 275 155 All SZGR 2.0 genes in this pathway