Gene Page:SLC22A7
Summary?
| GeneID | 10864 |
| Symbol | SLC22A7 |
| Synonyms | NLT|OAT2 |
| Description | solute carrier family 22 member 7 |
| Reference | MIM:604995|HGNC:HGNC:10971|Ensembl:ENSG00000137204|HPRD:05409|Vega:OTTHUMG00000014726 |
| Gene type | protein-coding |
| Map location | 6p21.1 |
| Pascal p-value | 1.427E-5 |
| eGene | Hippocampus |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GSMA_IIE | Genome scan meta-analysis (European-ancestry samples) | Psr: 0.04433 | |
| Expression | Meta-analysis of gene expression | Pvalue: 1.577 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ABCF2 | 0.91 | 0.91 |
| NPEPPS | 0.91 | 0.90 |
| RABGEF1 | 0.91 | 0.91 |
| CS | 0.91 | 0.91 |
| XPO7 | 0.91 | 0.92 |
| ZFYVE1 | 0.91 | 0.92 |
| PDXDC1 | 0.91 | 0.91 |
| NNT | 0.91 | 0.90 |
| ADD1 | 0.91 | 0.92 |
| POLR3A | 0.91 | 0.93 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.21 | -0.80 | -0.87 |
| MT-CO2 | -0.80 | -0.82 |
| AF347015.31 | -0.80 | -0.82 |
| AF347015.8 | -0.78 | -0.81 |
| AF347015.27 | -0.77 | -0.81 |
| MT-CYB | -0.77 | -0.79 |
| AF347015.33 | -0.77 | -0.78 |
| HIGD1B | -0.76 | -0.80 |
| IFI27 | -0.75 | -0.79 |
| FXYD1 | -0.75 | -0.80 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005215 | transporter activity | IEA | - | |
| GO:0008514 | organic anion transmembrane transporter activity | IEA | - | |
| GO:0015347 | sodium-independent organic anion transmembrane transporter activity | TAS | 9650585 | |
| GO:0015075 | ion transmembrane transporter activity | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0015711 | organic anion transport | TAS | 9650585 | |
| GO:0006811 | ion transport | IEA | - | |
| GO:0006810 | transport | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005624 | membrane fraction | TAS | 9650585 | |
| GO:0016021 | integral to membrane | IEA | - | |
| GO:0005886 | plasma membrane | IEA | - | |
| GO:0005887 | integral to plasma membrane | TAS | 9650585 | |
| GO:0016323 | basolateral plasma membrane | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES | 413 | 270 | All SZGR 2.0 genes in this pathway |
| REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT | 241 | 157 | All SZGR 2.0 genes in this pathway |
| REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS | 89 | 54 | All SZGR 2.0 genes in this pathway |
| REACTOME有机阳离子阴离子ZWITTERION TRANSPORT | 13 | 9 | All SZGR 2.0 genes in this pathway |
| JAZAG TGFB1 SIGNALING UP | 108 | 69 | All SZGR 2.0 genes in this pathway |
| SHETH LIVER CANCER VS TXNIP LOSS PAM4 | 261 | 153 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| CHEN METABOLIC SYNDROM NETWORK | 1210 | 725 | All SZGR 2.0 genes in this pathway |
| CAIRO HEPATOBLASTOMA DN | 267 | 160 | All SZGR 2.0 genes in this pathway |
| OHGUCHI LIVER HNF4A TARGETS DN | 149 | 85 | All SZGR 2.0 genes in this pathway |
| SERVITJA LIVER HNF1A TARGETS DN | 157 | 105 | All SZGR 2.0 genes in this pathway |
| GUILLAUMOND KLF10 TARGETS UP | 51 | 39 | All SZGR 2.0 genes in this pathway |