Gene Page:TSPAN9

Summary?
GeneID 10867
Symbol TSPAN9
Synonyms NET-5|NET5|PP1057
Description tetraspanin 9
Reference MIM:613137|HGNC:HGNC:21640|Ensembl:ENSG00000011105|HPRD:14823|Vega:OTTHUMG00000150333
Gene type protein-coding
Map location 12p13.33-p13.32
Pascal p-value 0.64
Fetal beta -0.066
DMG 2 (# studies)
eGene Cerebellar Hemisphere
Putamen basal ganglia
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Nishioka_2013 Genome-wide DNA methylation analysis The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 3
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 3

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg24281891 12 3194425 TSPAN9 3.543E-4 0.256 0.042 DMG:Wockner_2014
cg07248242 12 3281520 TSPAN9 4.576E-4 -0.366 0.046 DMG:Wockner_2014
cg00081935 12 3186906 TSPAN9 -0.023 0.81 DMG:Nishioka_2013

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs2502827 chr1 176044216 TSPAN9 10867 0.01 trans
rs12405921 chr1 206695730 TSPAN9 10867 0.14 trans
rs17572651 chr1 218943612 TSPAN9 10867 0.11 trans
rs16829545 chr2 151977407 TSPAN9 10867 1.794E-10 trans
rs3845734 chr2 171125572 TSPAN9 10867 1.584E-4 trans
rs7584986 chr2 184111432 TSPAN9 10867 3.854E-8 trans
rs17762315 chr5 76807576 TSPAN9 10867 0.04 trans
rs1368303 chr5 147672388 TSPAN9 10867 0.04 trans
rs1929769 chr6 40765977 TSPAN9 10867 0.18 trans
rs2393316 chr10 59333070 TSPAN9 10867 0.16 trans
rs17104720 chr14 77127308 TSPAN9 10867 0.05 trans
rs16955618 chr15 29937543 TSPAN9 10867 3.11E-23 trans
rs1041786 chr21 22617710 TSPAN9 10867 0 trans
rs11062561 12 3305091 TSPAN9 ENSG00000011105.7 2.107E-6 0 118570 gtex_brain_putamen_basal
rs11062562 12 3305394 TSPAN9 ENSG00000011105.7 2.098E-6 0 118873 gtex_brain_putamen_basal
rs12372425 12 3305905 TSPAN9 ENSG00000011105.7 2.098E-6 0 119384 gtex_brain_putamen_basal
rs73047986 12 3311182 TSPAN9 ENSG00000011105.7 2.098E-6 0 124661 gtex_brain_putamen_basal
rs11062564 12 3313540 TSPAN9 ENSG00000011105.7 9.572E-8 0 127019 gtex_brain_putamen_basal
rs7979334 12 3316270 TSPAN9 ENSG00000011105.7 9.579E-8 0 129749 gtex_brain_putamen_basal
rs2335666 12 3318258 TSPAN9 ENSG00000011105.7 1.06E-6 0 131737 gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
LILRA6 0.73 0.63
FPR1 0.46 0.34
CD14 0.46 0.28
VSIG4 0.46 0.36
CD68 0.45 0.34
SLC37A2 0.45 0.31
FCGR2A 0.44 0.37
SERPINA1 0.44 0.24
SIGLEC14 0.43 0.37
HMOX1 0.42 0.28
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
C5orf53 -0.26 -0.32
C10orf4 -0.25 -0.30
UQCRB -0.24 -0.32
NDUFB3 -0.22 -0.30
AC008670.2 -0.22 -0.38
MAP3K15 -0.22 -0.26
BXDC1 -0.22 -0.27
SERGEF -0.22 -0.24
AC104794.1 -0.21 -0.27
SERPINI1 -0.21 -0.22

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KORKOLA SEMINOMA UP 44 27 All SZGR 2.0 genes in this pathway
DAVICIONI MOLECULAR ARMS VS ERMS DN 182 111 All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL UP 133 78 All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP 239 157 All SZGR 2.0 genes in this pathway
TERAMOTO OPN TARGETS CLUSTER 6 27 17 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR UP 148 96 All SZGR 2.0 genes in this pathway
LEE METASTASIS AND ALTERNATIVE SPLICING UP 74 51 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540 340 All SZGR 2.0 genes in this pathway
KRISHNAN FURIN TARGETS DN 13 8 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN 668 419 All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS DN 213 127 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504 321 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898 516 All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS DN 315 215 All SZGR 2.0 genes in this pathway
DELACROIX RARG BOUND MEF 367 231 All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES 462 273 All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM B 517 302 All SZGR 2.0 genes in this pathway