Gene Page:ADCY3

Summary?
GeneID 109
象征 ADCY3
Synonyms AC-III|AC3
Description adenylate cyclase 3
Reference MIM:600291|HGNC:HGNC:234|Ensembl:ENSG00000138031|HPRD:02620|Vega:OTTHUMG00000094765
Gene type protein-coding
Map location 2p23.3
Pascal p-value 0.759
Fetal beta 0.427
eGene Frontal Cortex BA9
元
Support CANABINOID
DOPAMINE
INTRACELLULAR SIGNAL TRANSDUCTION
SEROTONIN
Ascano FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

部分即基因tics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ABCC1 0.92 0.92
ZNF862 0.92 0.93
LZTR1 0.91 0.91
KIAA0467 0.91 0.92
RANBP10 0.90 0.90
DIP2A 0.90 0.92
KIAA0913 0.90 0.92
INTS3 0.90 0.93
PLCG1 0.90 0.91
C17orf68 0.90 0.90
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.68 -0.77
AF347015.21 -0.66 -0.83
AF347015.27 -0.66 -0.74
MT-CO2 -0.65 -0.75
HIGD1B -0.63 -0.73
IFI27 -0.63 -0.69
C1orf54 -0.62 -0.80
C5orf53 -0.62 -0.64
MT-CYB -0.62 -0.70
FXYD1 -0.62 -0.68

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG PURINE METABOLISM 159 96 All SZGR 2.0 genes in this pathway
KEGG CALCIUM SIGNALING PATHWAY 178 134 All SZGR 2.0 genes in this pathway
KEGG CHEMOKINE SIGNALING PATHWAY 190 128 All SZGR 2.0 genes in this pathway
KEGG OOCYTE MEIOSIS 114 79 All SZGR 2.0 genes in this pathway
KEGG VASCULAR SMOOTH MUSCLE CONTRACTION 115 81 All SZGR 2.0 genes in this pathway
KEGG GAP JUNCTION 90 68 All SZGR 2.0 genes in this pathway
KEGG OLFACTORY TRANSDUCTION 389 85 All SZGR 2.0 genes in this pathway
KEGG GNRH SIGNALING PATHWAY 101 77 All SZGR 2.0 genes in this pathway
KEGG PROGESTERONE MEDIATED OOCYTE MATURATION 86 59 All SZGR 2.0 genes in this pathway
KEGG MELANOGENESIS 102 80 All SZGR 2.0 genes in this pathway
KEGG VASOPRESSIN REGULATED WATER REABSORPTION 44 30 All SZGR 2.0 genes in this pathway
KEGG霍乱弧菌感染 56 32 All SZGR 2.0 genes in this pathway
KEGG DILATED CARDIOMYOPATHY 92 68 All SZGR 2.0 genes in this pathway
PID ENDOTHELIN PATHWAY 63 52 All SZGR 2.0 genes in this pathway
PID LYSOPHOSPHOLIPID PATHWAY 66 53 All SZGR 2.0 genes in this pathway
PID LPA4 PATHWAY 15 10 All SZGR 2.0 genes in this pathway
REACTOMESIGNALLING BY NGF 217 167 All SZGR 2.0 genes in this pathway
REACTOMEDAG AND IP3 SIGNALING 32 25 All SZGR 2.0 genes in this pathway
由ERBB2 REACTOME信号 101 78 All SZGR 2.0 genes in this pathway
REACTOMESIGNALING BY EGFR IN CANCER 109 80 All SZGR 2.0 genes in this pathway
REACTOMENGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 137 105 All SZGR 2.0 genes in this pathway
REACTOMESIGNALING BY FGFR IN DISEASE 127 88 All SZGR 2.0 genes in this pathway
REACTOMETRANSMISSION ACROSS CHEMICAL SYNAPSES 186 155 All SZGR 2.0 genes in this pathway
REACTOMENEURONAL SYSTEM 279 221 All SZGR 2.0 genes in this pathway
REACTOMESIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOMEINTEGRATION OF ENERGY METABOLISM 120 84 All SZGR 2.0 genes in this pathway
REACTOMEOPIOID SIGNALLING 78 56 All SZGR 2.0 genes in this pathway
REACTOMECA DEPENDENT EVENTS 30 23 All SZGR 2.0 genes in this pathway
REACTOMEADENYLATE CYCLASE ACTIVATING PATHWAY 10 8 All SZGR 2.0 genes in this pathway
REACTOMEADENYLATE CYCLASE INHIBITORY PATHWAY 13 9 All SZGR 2.0 genes in this pathway
REACTOMENEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 137 110 All SZGR 2.0 genes in this pathway
REACTOMEPLC BETA MEDIATED EVENTS 43 32 All SZGR 2.0 genes in this pathway
REACTOMEPKA MEDIATED PHOSPHORYLATION OF CREB 18 14 All SZGR 2.0 genes in this pathway
REACTOMETRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413 270 All SZGR 2.0 genes in this pathway
REACTOMEGLUCAGON SIGNALING IN METABOLIC REGULATION 34 23 All SZGR 2.0 genes in this pathway
REACTOMESIGNALING BY PDGF 122 93 All SZGR 2.0 genes in this pathway
REACTOMEDOWNSTREAM SIGNAL TRANSDUCTION 95 76 All SZGR 2.0 genes in this pathway
REACTOMEGPCR DOWNSTREAM SIGNALING 805 368 All SZGR 2.0 genes in this pathway
REACTOMEG ALPHA I SIGNALLING EVENTS 195 114 All SZGR 2.0 genes in this pathway
REACTOMEG ALPHA S SIGNALLING EVENTS 121 82 All SZGR 2.0 genes in this pathway
REACTOMEG ALPHA Z SIGNALLING EVENTS 44 29 All SZGR 2.0 genes in this pathway
REACTOMEACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 37 32 All SZGR 2.0 genes in this pathway
REACTOMEPOST NMDA RECEPTOR ACTIVATION EVENTS 33 28 All SZGR 2.0 genes in this pathway
REACTOMEDOWNSTREAM SIGNALING OF ACTIVATED FGFR 100 74 All SZGR 2.0 genes in this pathway
REACTOMEPHOSPHOLIPASE C MEDIATED CASCADE 54 40 All SZGR 2.0 genes in this pathway
REACTOMEAQUAPORIN MEDIATED TRANSPORT 51 34 All SZGR 2.0 genes in this pathway
REACTOMEREGULATION OF WATER BALANCE BY RENAL AQUAPORINS 44 30 All SZGR 2.0 genes in this pathway
REACTOMEGABA B RECEPTOR ACTIVATION 38 26 All SZGR 2.0 genes in this pathway
REACTOMEGABA RECEPTOR ACTIVATION 52 40 All SZGR 2.0 genes in this pathway
REACTOMESIGNALING BY FGFR 112 80 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783 507 All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 6HR UP 55 34 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485 334 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552 347 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION UP 211 136 All SZGR 2.0 genes in this pathway
SCHLOSSER MYC TARGETS AND SERUM RESPONSE DN 47 34 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN 337 230 All SZGR 2.0 genes in this pathway
WANG TARGETS OF MLL CBP FUSION UP 44 26 All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED DN 246 180 All SZGR 2.0 genes in this pathway
CHUANG OXIDATIVE STRESS RESPONSE DN 11 9 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
KIM GASTRIC CANCER CHEMOSENSITIVITY 103 64 All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN 287 208 All SZGR 2.0 genes in this pathway
BILD E2F3 ONCOGENIC SIGNATURE 246 153 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528 324 All SZGR 2.0 genes in this pathway
PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION UP 64 40 All SZGR 2.0 genes in this pathway
RIGGINS TAMOXIFEN RESISTANCE DN 220 147 All SZGR 2.0 genes in this pathway
MARZEC IL2 SIGNALING UP 115 80 All SZGR 2.0 genes in this pathway
MATZUK SPERMATOZOA 114 77 All SZGR 2.0 genes in this pathway
WHITEFORD PEDIATRIC CANCER MARKERS 116 63 All SZGR 2.0 genes in this pathway
NAKAMURA METASTASIS MODEL UP 45 26 All SZGR 2.0 genes in this pathway
YAMASHITA LIVER CANCER STEM CELL DN 76 51 All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION 368 247 All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED 351 238 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 491 319 All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS VIA AKT1 UP 281 183 All SZGR 2.0 genes in this pathway
ALFANO MYC TARGETS 239 156 All SZGR 2.0 genes in this pathway
DURAND STROMA S UP 297 194 All SZGR 2.0 genes in this pathway