Gene Page:PNRC1
概括?
基因 | 10957 |
Symbol | PNRC1 |
Synonyms | B4-2|PNAS-145|PROL2|PRR2 |
Description | proline rich nuclear receptor coactivator 1 |
Reference | MIM:606714|HGNC:HGNC:17278|Ensembl:ENSG00000146278|HPRD:08412|Vega:OTTHUMG00000015191 |
Gene type | protein-coding |
Map location | 6q15 |
Pascal p-value | 0.621 |
Fetal beta | 0.126 |
数据源中的基因
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:GWASDB | Genome-wide Association Studies | GWASdb records for schizophrenia | |
CV:PGCnp | Genome-wide Association Study | GWAS |
第一节遗传学和表观遗传学注释
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
脚注:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
脚注:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
TIAL1 | 0.89 | 0.90 |
XPO1 | 0.88 | 0.90 |
LUC7L2 | 0.88 | 0.89 |
SF3B1 | 0.88 | 0.91 |
UHRF2 | 0.87 | 0.90 |
PRPF4B | 0.87 | 0.90 |
DDX46 | 0.87 | 0.89 |
SUZ12 | 0.87 | 0.90 |
SENP6 | 0.87 | 0.90 |
GPBP1 | 0.87 | 0.89 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
AF347015.31 | -0.74 | -0.84 |
MT-CO2 | -0.73 | -0.84 |
AF347015.27 | -0.72 | -0.82 |
FXYD1 | -0.71 | -0.82 |
AF347015.33 | -0.71 | -0.81 |
AF347015.8 | -0.71 | -0.82 |
MT-CYB | -0.70 | -0.81 |
IFI27 | -0.70 | -0.83 |
AF347015.15 | -0.68 | -0.80 |
HIGD1B | -0.68 | -0.81 |
Section III. Gene Ontology annotation
Molecular function | 去的术语 | Evidence | Neuro keywords | PubMed ID |
---|---|---|---|---|
GO:0005515 | protein binding | TAS | 7578250 | |
生物过程 | 去的术语 | Evidence | Neuro keywords | PubMed ID |
去:0006355 | regulation of transcription, DNA-dependent | IEA | - | |
去:0006350 | transcription | IEA | - | |
Cellular component | 去的术语 | Evidence | Neuro keywords | PubMed ID |
GO:0005634 | nucleus | TAS | 7578250 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
PARENT MTOR SIGNALING UP | 567 | 375 | 该途径中的所有SZGR 2.0基因 |
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN | 634 | 384 | 该途径中的所有SZGR 2.0基因 |
ZHOU INFLAMMATORY RESPONSE LIVE UP | 485 | 293 | 该途径中的所有SZGR 2.0基因 |
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC UP | 185 | 126 | 该途径中的所有SZGR 2.0基因 |
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION ERYTHROCYTE UP | 157 | 104 | 该途径中的所有SZGR 2.0基因 |
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION SUSTAINDED IN ERYTHROCYTE UP | 44 | 30 | 该途径中的所有SZGR 2.0基因 |
TIEN INTESTINE PROBIOTICS 24HR DN | 214 | 133 | 该途径中的所有SZGR 2.0基因 |
ZHOU INFLAMMATORY RESPONSE FIMA UP | 544 | 308 | 该途径中的所有SZGR 2.0基因 |
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN | 805 | 505 | 该途径中的所有SZGR 2.0基因 |
ENK UV RESPONSE EPIDERMIS DN | 508 | 354 | 该途径中的所有SZGR 2.0基因 |
LINDGREN BLADDER CANCER CLUSTER 1 UP | 121 | 71 | 该途径中的所有SZGR 2.0基因 |
GAUSSMANN MLL AF4 FUSION TARGETS F UP | 185 | 119 | 该途径中的所有SZGR 2.0基因 |
DACOSTA UV RESPONSE VIA ERCC3 UP | 309 | 199 | 该途径中的所有SZGR 2.0基因 |
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP | 479 | 299 | 该途径中的所有SZGR 2.0基因 |
GROSS HYPOXIA VIA ELK3 DN | 156 | 106 | 该途径中的所有SZGR 2.0基因 |
GROSS HYPOXIA VIA HIF1A DN | 110 | 78 | 该途径中的所有SZGR 2.0基因 |
GROSS HYPOXIA VIA ELK3 AND HIF1A UP | 142 | 104 | 该途径中的所有SZGR 2.0基因 |
NUYTTEN EZH2 TARGETS UP | 1037 | 673 | 该途径中的所有SZGR 2.0基因 |
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP | 811 | 508 | 该途径中的所有SZGR 2.0基因 |
BENPORATH ES CORE NINE CORRELATED | 100 | 68 | 该途径中的所有SZGR 2.0基因 |
AMIT SERUM RESPONSE 60 MCF10A | 57 | 42 | 该途径中的所有SZGR 2.0基因 |
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP | 223 | 140 | 该途径中的所有SZGR 2.0基因 |
ONDER CDH1 TARGETS 1 UP | 140 | 85 | 该途径中的所有SZGR 2.0基因 |
西葫芦转移DN | 44 | 29 | 该途径中的所有SZGR 2.0基因 |
UEDA CENTRAL CLOCK | 88 | 62 | 该途径中的所有SZGR 2.0基因 |
UEDA PERIFERAL CLOCK | 169 | 111 | 该途径中的所有SZGR 2.0基因 |
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE UP | 157 | 105 | 该途径中的所有SZGR 2.0基因 |
IVANOVA HEMATOPOIESIS STEM CELL | 254 | 164 | 该途径中的所有SZGR 2.0基因 |
CHIBA RESPONSE TO TSA | 50 | 31 | 该途径中的所有SZGR 2.0基因 |
Dacosta UV响应通过ERCC3 common | 77 | 47 | 该途径中的所有SZGR 2.0基因 |
SARRIO EPITHELIAL MESENCHYMAL TRANSITION DN | 154 | 101 | 该途径中的所有SZGR 2.0基因 |
MITSIADES RESPONSE TO APLIDIN UP | 439 | 257 | 该途径中的所有SZGR 2.0基因 |
PODAR RESPONSE TO ADAPHOSTIN UP | 147 | 98 | 该途径中的所有SZGR 2.0基因 |
LINDSTEDT DENDRITIC CELL MATURATION B | 53 | 36 | 该途径中的所有SZGR 2.0基因 |
RUIZ TNC TARGETS UP | 153 | 107 | 该途径中的所有SZGR 2.0基因 |
CHANG CORE SERUM RESPONSE DN | 209 | 137 | 该途径中的所有SZGR 2.0基因 |
Hinata NFKB靶向角质形成细胞 | 91 | 63 | 该途径中的所有SZGR 2.0基因 |
ZHANG TLX TARGETS 60HR UP | 293 | 203 | 该途径中的所有SZGR 2.0基因 |
YAGI AML WITH T 8 21 TRANSLOCATION | 368 | 247 | 该途径中的所有SZGR 2.0基因 |
STEIN ESR1 TARGETS | 85 | 55 | 该途径中的所有SZGR 2.0基因 |
WONG ADULT TISSUE STEM MODULE | 721 | 492 | 该途径中的所有SZGR 2.0基因 |
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 0 | 76 | 54 | 该途径中的所有SZGR 2.0基因 |
KARLSSON TGFB1 TARGETS DN | 207 | 139 | 该途径中的所有SZGR 2.0基因 |
HIRSCH CELLULAR TRANSFORMATION SIGNATURE UP | 242 | 159 | 该途径中的所有SZGR 2.0基因 |
Dutertre雌二醇反应24小时DN | 505 | 328 | 该途径中的所有SZGR 2.0基因 |
JOHNSTONE PARVB TARGETS 3 UP | 430 | 288 | 该途径中的所有SZGR 2.0基因 |
LEE BMP2 TARGETS UP | 745 | 475 | 该途径中的所有SZGR 2.0基因 |
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN | 1080 | 713 | 该途径中的所有SZGR 2.0基因 |
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 36HR | 152 | 88 | 该途径中的所有SZGR 2.0基因 |
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D | 882 | 506 | 该途径中的所有SZGR 2.0基因 |
KRIEG HYPOXIA NOT VIA KDM3A | 770 | 480 | 该途径中的所有SZGR 2.0基因 |
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | 该途径中的所有SZGR 2.0基因 |
Section VI. microRNA annotation
miRNA family | Target position | miRNA ID | miRNA seq | ||
---|---|---|---|---|---|
UTR start | UTR end | Match method | |||
miR-101 | 168 | 174 | 1A | HSA-MIR-101 | UACAGUACUGUGAUAACUGAAG |
miR-144 | 167 | 174 | 1A,m8 | hsa-miR-144 | UACAGUAUAGAUGAUGUACUAG |
miR-19 | 331 | 338 | 1A,m8 | hsa-miR-19a | UGUGCAAAUCUAUGCAAAACUGA |
hsa-miR-19b | ugugcaaauccaugcaaaacuga | ||||
miR-219 | 439 | 445 | 1A | hsa-miR-219brain | UGAUUGUCCAAACGCAAUUCU |
miR-26 | 202 | 208 | m8 | hsa-miR-26abrain | UUCAAGUAAUCCAGGAUAGGC |
hsa-miR-26bSZ | uucaaguaauucaggauagguu | ||||
miR-369-3p | 144 | 151 | 1A,m8 | hsa-miR-369-3p | AAUAAUACAUGGUUGAUCUUU |
hsa-miR-369-3p | AAUAAUACAUGGUUGAUCUUU | ||||
mir-374 | 145 | 151 | m8 | hsa-miR-374 | UUAUAAUACAACCUGAUAAGUG |
miR-381 | 270 | 276 | 1A | hsa-miR-381 | UAUACAAGGGCAAGCUCUCUGU |
hsa-miR-381 | UAUACAAGGGCAAGCUCUCUGU | ||||
mir-495 | 224 | 230 | 1A | hsa-miR-495brain | AAACAAACAUGGUGCACUUCUUU |
- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Clickhereto see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Clickhereto see the list of brain related miRNAs.