SZGR2 - Beplay体育中心

Summary？

基因	10979
象征	FERMT2
Synonyms	KIND2\|MIG2\|PLEKHC1\|UNC112\|UNC112B\|mig-2
Description	fermitin family member 2
Reference	MIM:607746\|HGNC：HGNC：15767\|ENSEMBL：ENSG0000000073712\|HPRD:06374\|Vega：Otthumg00000140309
基因类型	蛋白质编码
Map location	14Q22.1
pascal p-value	0.523
Sherlock p-value	0.115
胎儿β	0.644
DMG	1(# studies)

Gene in Data Sources

基因集名称	Method of gene set	Description	信息
CV:PGCnp	全基因组协会研究	GWAS
DMG：Wockner_2014	全基因组DNA甲基化分析	该数据集包括4641个差异甲基化探针，对应于精神分裂症患者（n = 24）和对照组（n = 24）之间的2929个独特基因。	1
表达	Meta-analysis of gene expression	pvalue: 1.474

Section I. Genetics and epigenetics annotation

差异甲基化基因

probe	染色体	位置	最近的基因	p（dis）	Beta (dis)	fdr（dis）	学习
CG14077965	14	53418979	FERMT2	1.85e-5	-0.431	0.016	DMG：Wockner_2014

第二节。转录组注释

一般基因表达（GTEX）

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

前10个积极共表达的基因
Gene	pearson's Correlation	斯皮尔曼的相关性
UBE3C	0.68	0.74
RDH14	0.67	0.69
GPRASP2	0.66	0.68
C14orf153	0.66	0.73
AFG3L2	0.66	0.69
AP2A2	0.65	0.70
GALNT11	0.65	0.69
NRBF2	0.65	0.69
snap91	0.65	0.74
CAND2	0.65	0.74

Top 10 negatively co-expressed genes
Gene	pearson's Correlation	斯皮尔曼的相关性
AF347015.21	-0.58	-0.54
AP002478.3	-0.52	-0.53
MT-CO2	-0.51	-0.48
AF347015.8	-0.51	-0.47
鼻孔	-0.51	-0.45
FXYD1	-0.50	-0.45
AF347015.33	-0.50	-0.44
AF347015.18	-0.49	-0.46
MT1G	-0.49	-0.45
clec2b	-0.48	-0.49

第三节。基因本体论注释

分子功能	去学期	证据	神经关键字	PubMed ID
去：0005515	蛋白质结合	nas		-
生物过程	去学期	证据	神经关键字	PubMed ID
GO:0007155	cell adhesion	nas		-
GO:0008360	regulation of cell shape	我EA		-
GO:0030036	actin cytoskeleton organization	nas		-
Cellular component	去学期	证据	神经关键字	PubMed ID
GO:0001725	压力纤维	nas		-
去：0005856	细胞骨架	我EA		-
去：0005737	cytoplasm	我EA		-
GO:0030054	cell junction	我EA		-

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
REACTOME CELL CELL COMMUNICATION	120	77	All SZGR 2.0 genes in this pathway
反应组细胞外基质相互作用	14	10	All SZGR 2.0 genes in this pathway
Reactome细胞连接组织	78	43	All SZGR 2.0 genes in this pathway
Piccaluga血管免疫细胞淋巴瘤	205	140	All SZGR 2.0 genes in this pathway
刘前列腺癌DN	481	290	All SZGR 2.0 genes in this pathway
Bertucci髓质与导管乳腺癌DN	169	118	All SZGR 2.0 genes in this pathway
Schuetz乳腺癌导管侵入性	351	230	All SZGR 2.0 genes in this pathway
ZHONG RESPONSE TO AZACITIDINE AND TSA UP	183	119	All SZGR 2.0 genes in this pathway
周的炎症反应生活	485	293	All SZGR 2.0 genes in this pathway
胶原蛋白凝胶中的Oswald造血干细胞	233	161	All SZGR 2.0 genes in this pathway
NUP98 HOXA9 Fusion 10D的Takeda目标	194	122	All SZGR 2.0 genes in this pathway
runx1 runx1t1融合单核细胞的TONKS目标	204	140	All SZGR 2.0 genes in this pathway
Dittmer PTHLH靶向DN	73	51	All SZGR 2.0 genes in this pathway
Tien肠益生菌2小时DN	88	53	All SZGR 2.0 genes in this pathway
Tien肠益生菌6小时DN	167	100	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP	544	308	All SZGR 2.0 genes in this pathway
Nagashima NRG1信号向上发出	176	123	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS UP	214	155	All SZGR 2.0 genes in this pathway
Kim WT1靶向12小时	162	116	All SZGR 2.0 genes in this pathway
Wamunyokoli卵巢癌LMP DN	199	124	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP	633	376	All SZGR 2.0 genes in this pathway
Gozgit ESR1靶向	149	84	All SZGR 2.0 genes in this pathway
BERENJENO ROCK SIGNALING NOT VIA RHOA DN	48	34	All SZGR 2.0 genes in this pathway
阿霉素DN的Graessmann凋亡	1781	1082	All SZGR 2.0 genes in this pathway
Graessmann对MC和阿霉素DN的反应	770	415	All SZGR 2.0 genes in this pathway
roversi神经胶质瘤区域	44	30	All SZGR 2.0 genes in this pathway
Dacosta UV响应通过ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
Dacosta UV响应通过ERCC3公共DN	483	336	All SZGR 2.0 genes in this pathway
Martoriati MDM4靶向胎儿肝DN	514	319	All SZGR 2.0 genes in this pathway
Nuytten Nipp1靶向	769	437	All SZGR 2.0 genes in this pathway
Nuytten EZH2靶向	1037	673	All SZGR 2.0 genes in this pathway
阿米特血清反应120 MCF10A	65	44	All SZGR 2.0 genes in this pathway
Nikolsky乳腺癌14Q22 AMPLICON	14	7	All SZGR 2.0 genes in this pathway
Onder CDH1目标2向上	256	159	All SZGR 2.0 genes in this pathway
通过CTNNB1发出的CDH1信号传导	83	58	All SZGR 2.0 genes in this pathway
史密斯·泰特（Smith Tert）	145	91	All SZGR 2.0 genes in this pathway
Iizuka肝癌进展G2 G3 UP	28	14	All SZGR 2.0 genes in this pathway
宁慢性阻塞性肺疾病DN	121	79	All SZGR 2.0 genes in this pathway
UEDA PERIFERAL CHICK	169	111	All SZGR 2.0 genes in this pathway
甜蜜的克拉斯靶向	84	51	All SZGR 2.0 genes in this pathway
Iizuka肝癌进展L1 G1 UP	25	15	All SZGR 2.0 genes in this pathway
Cromer转移	79	46	All SZGR 2.0 genes in this pathway
整合素信号传导	59	44	All SZGR 2.0 genes in this pathway
Zhan多发性骨髓瘤CD1和CD2 UP	89	51	All SZGR 2.0 genes in this pathway
阿尔茨海默氏病dn	1237	837	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN	830	547	All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC DN	228	146	All SZGR 2.0 genes in this pathway
外邦紫外线响应集群D5	39	26	All SZGR 2.0 genes in this pathway
大脑衰老	262	186	All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE DN	312	203	All SZGR 2.0 genes in this pathway
Dazard对UV NHEK DN的反应	318	220	All SZGR 2.0 genes in this pathway
TSENG IRS1 TARGETS UP	113	71	All SZGR 2.0 genes in this pathway
贝尔德糖尿病性肾病DN	434	302	All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G6	153	112	All SZGR 2.0 genes in this pathway
JIANG HYPOXIA CANCER	83	52	All SZGR 2.0 genes in this pathway
伯顿成生成9	92	59	All SZGR 2.0 genes in this pathway
Massarweh tamoxifen抗性	578	341	All SZGR 2.0 genes in this pathway
MCCABE BOUND BY HOXC6	469	239	All SZGR 2.0 genes in this pathway
阿塞维多肝癌DN	540	340	All SZGR 2.0 genes in this pathway
SMID乳腺癌腔B DN	564	326	All SZGR 2.0 genes in this pathway
ehlers neuploidy up	41	29	All SZGR 2.0 genes in this pathway
Bohn原发性免疫缺陷综合症	47	30	All SZGR 2.0 genes in this pathway
Lindstedt树突状细胞成熟C	69	49	All SZGR 2.0 genes in this pathway
甜肺癌Kras DN	435	289	All SZGR 2.0 genes in this pathway
HOFMANN MYELODYSPLASTIC SYNDROM LOW RISK DN	30	20	All SZGR 2.0 genes in this pathway
HOFMANN MYELODYSPLASTIC SYNDROM RISK UP	24	14	All SZGR 2.0 genes in this pathway
winnepenninckx黑色素瘤转移	162	86	All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE	721	492	All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN	505	328	All SZGR 2.0 genes in this pathway
Gabriely miR21靶标	289	187	All SZGR 2.0 genes in this pathway
Pilon KLF1靶向	504	321	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN	918	550	All SZGR 2.0 genes in this pathway
林乳腺干细胞向上	489	314	All SZGR 2.0 genes in this pathway
Zwang 3类由EGF瞬时诱导	222	159	All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族	Target position			miRNA ID	mirna seq
mirna家族	UTR开始	UTR结束	匹配方法	miRNA ID	mirna seq
mir-124.1	121	127	M8	HSA-MIR-124A	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	121	127	1a	hsa-miR-506	uaaggcacccuucugugaguaga
miR-124/506	121	127	1a	HSA-MIR-124^brain	UAAGGCACGCGGUGAAUGCC
mir-130/301	145	151	1a	hsa-miR-130a^brain	cagugcaauguaaaaggggau
				hsa-miR-301	cagugcaauaugucaaagc
				hsa-miR-130b^brain	Cagugcaaugaagggauggau
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
miR-138	630	637	1A，M8	HSA-MIR-138^brain	AGCUGGUGUUGUGAAUC
miR-15/16/195/424/497	68	74	M8	HSA-MIR-15A^brain	uagcagcacauaugguugug
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				HSA-MIR-15B^brain	UAGCAGCACAUCAUGGUUUACA
				HSA-MIR-195^SZ	uagcagaaaaauauuggc
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				HSA-MIR-497	cagcagcacacuguguuugu
miR-200bc/429	1027	1033	M8	hsa-miR-200b	uaauacugccugguaaugaugac
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
mir-205	512	518	1a	hsa-miR-205	UCCUUCAUUCCACCGGAGUCUG
mir-221/222	791	798	1A，M8	hsa-miR-221^brain	agcuacauugucugugggggguc
mir-221/222	791	798	1A，M8	hsa-miR-222^brain	agcuacaucuggcuacugggucuc
miR-29	963	970	1A，M8	HSA-MIR-29A^SZ	UAGCACCAUCUGAAAUCGGUU
				HSA-MIR-29B^SZ	UAGCACCAUUUGAAAUCAGUGUU
				HSA-MIR-29C^SZ	uagcaccauuugaaaucggu
miR-34b	648	654	1a	hsa-miR-34b	uaggcagugucauagcugauug
miR-376	693	700	1A，M8	HSA-MIR-376A	aucauagaaaaauccacgu
miR-376	693	700	1A，M8	HSA-MIR-376B	AUCAUAGAGGAAAAUCCAUGUU

SZ：在精神分裂症患者的脑皮质中差异表达的miRNA与使用微阵列进行对照样品进行比较。点击hereto see the list of SZ related miRNAs.
大脑：基于miRNA微阵列表达研究在大脑中表达的miRNA。点击here查看与大脑相关的miRNA列表。

Gene Page:FERMT2