Gene Page:TLK2

Summary?
GeneID 11011
Symbol TLK2
Synonyms HsHPK|PKU-ALPHA
Description tousled like kinase 2
Reference MIM:608439|HGNC:HGNC:11842|HPRD:10527|
Gene type 公关otein-coding
Map location 17q23
Pascal p-value 0.044
Sherlock p-value 0.907
TADA p-value 0.013
Fetal beta 0.509

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DNM:Gulsuner_2013 Whole Exome Sequencing analysis 155 DNMs identified by exome sequencing of quads or trios of schizophrenia individuals and their parents.
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0673

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
TLK2 chr17 60642438 G A NM_001112707
NM_006852		 p.271R>Q
p.303R>Q		 missense
missense		 Schizophrenia DNM:Gulsuner_2013


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception凌晨ks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ALDH1L1 0.91 0.90
METTL7A 0.86 0.90
MERTK 0.86 0.90
RANBP3L 0.85 0.88
ALDH6A1 0.85 0.89
MRO 0.85 0.87
HTRA1 0.85 0.91
NDRG2 0.84 0.88
ALDH2 0.84 0.84
CYP4F11 0.84 0.85
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
PHF14 -0.58 -0.70
MLLT11 -0.57 -0.65
PPP3CC -0.57 -0.68
DPF1 -0.57 -0.65
MED19 -0.57 -0.70
RNF19B -0.57 -0.67
FAM40A -0.57 -0.63
STMN2 -0.57 -0.68
MPP3 -0.56 -0.64
RTF1 -0.56 -0.65

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0005515 公关otein binding 新闻学会 17353931
GO:0005524 ATP binding IDA 12660173
GO:0004674 公关otein serine/threonine kinase activity IDA 12660173
GO:0004674 公关otein serine/threonine kinase activity NAS 9427565|10523312
GO:0016740 transferase activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0001672 regulation of chromatin assembly or disassembly IDA 12660173
GO:0006468 公关otein amino acid phosphorylation IDA 12660173
GO:0007242 intracellular signaling cascade IDA 12660173
GO:0007049 cell cycle IEA -
GO:0006974 response to DNA damage stimulus IEA -
GO:0016568 chromatin modification IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IDA 9427565
GO:0005634 nucleus NAS -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
DAVICIONI MOLECULAR ARMS VS ERMS UP 332 228 All SZGR 2.0 genes in this pathway
BIDUS METASTASIS UP 214 134 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485 334 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP 329 196 All SZGR 2.0 genes in this pathway
HEIDENBLAD AMPLIFIED IN PANCREATIC CANCER 31 19 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN 483 336 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423 265 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON 335 181 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 All SZGR 2.0 genes in this pathway
PARK HSC MARKERS 44 31 All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV SCC DN 123 86 All SZGR 2.0 genes in this pathway
GENTILE UV RESPONSE CLUSTER D5 39 26 All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE DN 312 203 All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK DN 318 220 All SZGR 2.0 genes in this pathway
CHENG RESPONSE TO NICKEL ACETATE 45 29 All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G6 153 112 All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN 409 268 All SZGR 2.0 genes in this pathway
CHEN HOXA5 TARGETS 9HR UP 223 132 All SZGR 2.0 genes in this pathway
WENDT COHESIN TARGETS UP 33 19 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518 299 All SZGR 2.0 genes in this pathway
WOO LIVER CANCER RECURRENCE UP 105 75 All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 718 401 All SZGR 2.0 genes in this pathway
MIKKELSEN NPC ICP WITH H3K4ME3 445 257 All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS UP 295 155 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-101 300 306 m8 hsa - mir - 101 UACAGUACUGUGAUAACUGAAG
miR-125/351 326 332 m8 hsa-miR-125bbrain UCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrain UCCCUGAGACCCUUUAACCUGUG
miR-128 302 308 1A hsa-miR-128a UCACAGUGAACCGGUCUCUUUU
hsa-miR-128b UCACAGUGAACCGGUCUCUUUC
miR-217 921 927 m8 hsa-miR-217 UACUGCAUCAGGAACUGAUUGGAU
miR-218 463 469 1A hsa-miR-218brain UUGUGCUUGAUCUAACCAUGU
miR-22 185 191 m8 hsa-miR-22brain AAGCUGCCAGUUGAAGAACUGU
miR-26 369 375 1A hsa-miR-26abrain UUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZ UUCAAGUAAUUCAGGAUAGGUU
miR-27 302 309 1A,m8 hsa-miR-27abrain UUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrain UUCACAGUGGCUAAGUUCUGC
miR-320 681 687 m8 hsa-miR-320 AAAAGCUGGGUUGAGAGGGCGAA
miR-384 206 212 1A hsa-miR-384 AUUCCUAGAAAUUGUUCAUA