Gene Page:KDELR2

Summary?
GeneID 11014
Symbol KDELR2
Synonyms ELP-1|ERD2.2
Description KDEL endoplasmic reticulum protein retention receptor 2
Reference MIM:609024|HGNC:HGNC:6305|Ensembl:ENSG00000136240|HPRD:06598|Vega:OTTHUMG00000023103
Gene type protein-coding
Map location 7p22.1
Pascal p-value 0.331
Sherlock p-value 0.482
DMG 1 (# studies)

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg16433771 7 6523888 KDELR2 9.08E-9 -0.009 4.12E-6 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26所示postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
IGDCC3 0.94 0.91
DNMT3B 0.91 0.84
KIAA1305 0.90 0.89
LPAR2 0.89 0.83
TRIOBP 0.89 0.91
DCHS1 0.89 0.93
SEMA6C 0.89 0.82
PLEKHG2 0.88 0.90
NINL 0.88 0.89
PLXNA3 0.88 0.87
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
FBXO2 -0.61 -0.65
C5orf53 -0.60 -0.78
ALDOC -0.60 -0.65
HLA-F -0.60 -0.63
ACOT13 -0.59 -0.76
AIFM3 -0.59 -0.59
FAM162A -0.59 -0.76
LHPP -0.59 -0.56
LDHD -0.58 -0.60
CA4 -0.57 -0.72

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG霍乱弧菌感染 56 32 All SZGR 2.0 genes in this pathway
BIOCARTA ARAP PATHWAY 18 13 All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663 425 All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN 362 238 All SZGR 2.0 genes in this pathway
DITTMER PTHLH TARGETS DN 73 51 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP UP 265 158 All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER GRADES 1 2 UP 137 84 All SZGR 2.0 genes in this pathway
PROVENZANI METASTASIS DN 136 94 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 DN 378 231 All SZGR 2.0 genes in this pathway
OUELLET OVARIAN CANCER INVASIVE VS LMP UP 117 85 All SZGR 2.0 genes in this pathway
WANG BARRETTS ESOPHAGUS UP 51 27 All SZGR 2.0 genes in this pathway
WANG ESOPHAGUS CANCER VS NORMAL UP 121 72 All SZGR 2.0 genes in this pathway
WOOD EBV EBNA1 TARGETS DN 47 33 All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN 848 527 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN 514 330 All SZGR 2.0 genes in this pathway
PASQUALUCCI LYMPHOMA BY GC STAGE UP 283 177 All SZGR 2.0 genes in this pathway
BENPORATH PROLIFERATION 147 80 All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS B LYMPHOCYTE UP 78 51 All SZGR 2.0 genes in this pathway
IIZUKA LIVER CANCER PROGRESSION G2 G3 UP 28 14 All SZGR 2.0 genes in this pathway
SANA RESPONSE TO IFNG DN 85 56 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL LONG TERM 302 191 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
RHODES CANCER META SIGNATURE 64 47 All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE UP 249 170 All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS UP 175 116 All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS UP 198 132 All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN 287 208 All SZGR 2.0 genes in this pathway
BACOLOD RESISTANCE TO ALKYLATING AGENTS DN 60 45 All SZGR 2.0 genes in this pathway
JIANG HYPOXIA CANCER 83 52 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720 440 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 5 482 296 All SZGR 2.0 genes in this pathway
PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION UP 64 40 All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE UP 578 341 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973 570 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863 514 All SZGR 2.0 genes in this pathway
CUI GLUCOSE DEPRIVATION 60 44 All SZGR 2.0 genes in this pathway
BOHN PRIMARY IMMUNODEFICIENCY SYNDROM UP 47 30 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN 668 419 All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2 277 172 All SZGR 2.0 genes in this pathway
WINNEPENNINCKX MELANOMA METASTASIS UP 162 86 All SZGR 2.0 genes in this pathway
BAUS TFF2 TARGETS UP 32 22 All SZGR 2.0 genes in this pathway
NIELSEN GIST 98 66 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP D 280 158 All SZGR 2.0 genes in this pathway