Gene Page:IFT27

Summary?
GeneID 11020
Symbol IFT27
Synonyms BBS19|RABL4|RAYL
Description intraflagellar transport 27
Reference MIM:615870|HGNC:HGNC:18626|Ensembl:ENSG00000100360|Vega:OTTHUMG00000150544
Gene type protein-coding
Map location 22q13.1
Pascal p-value 0.008
Sherlock p-value 0.717
Fetal beta -0.783
eGene Caudate basal ganglia
Cortex
Frontal Cortex BA9
Nucleus accumbens basal ganglia
Putamen basal ganglia
元

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs3827351 22 37157240 IFT27 ENSG00000100360.10 8.50745E-7 0.01 15060 gtex_brain_putamen_basal
rs1048015 22 37163080 IFT27 ENSG00000100360.10 2.96297E-6 0.01 9220 gtex_brain_putamen_basal
rs5750306 22 37170915 IFT27 ENSG00000100360.10 1.0358E-6 0.01 1385 gtex_brain_putamen_basal
rs5750307 22 37170977 IFT27 ENSG00000100360.10 1.0358E-6 0.01 1323 gtex_brain_putamen_basal
rs8135284 22 37182681 IFT27 ENSG00000100360.10 1.9563E-6 0.01 -10381 gtex_brain_putamen_basal
rs9607382 22 37191418 IFT27 ENSG00000100360.10 3.33923E-6 0.01 -19118 gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception一周s), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
HDAC6 0.96 0.96
RAF1 0.96 0.94
DCAF15 0.95 0.95
JUP 0.95 0.94
RBM15B 0.95 0.95
CSNK1E 0.95 0.94
IFT140 0.95 0.95
AKT1 0.95 0.94
EHMT2 0.94 0.95
NUP62 0.94 0.93
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
C5orf53 -0.77 -0.78
AF347015.27 -0.77 -0.88
AF347015.31 -0.76 -0.87
MT-CO2 -0.75 -0.88
AF347015.33 -0.74 -0.85
S100B -0.74 -0.82
HLA-F -0.73 -0.73
MT-CYB -0.72 -0.84
AIFM3 -0.72 -0.71
AF347015.8 -0.72 -0.86

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493 298 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142 669 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612 367 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024 594 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL FLI1 9 8 All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN 287 208 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 2 473 224 All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED 728 415 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS UP 388 234 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS 535 325 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857 456 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE EARLY LATE 317 190 All SZGR 2.0 genes in this pathway
KUMAR PATHOGEN LOAD BY MACROPHAGES 275 155 All SZGR 2.0 genes in this pathway