Gene Page:STON1

概括?
GeneID 11037
Symbol STON1
Synonyms SALF|SBLF|STN1|STNB1
Description stonin 1
Reference MIM:605357|HGNC:HGNC:17003|Ensembl:ENSG00000243244|HPRD:16100|Vega:OTTHUMG00000129169
Gene type protein-coding
Map location 2p16.3
Pascal p-value 0.004
Sherlock p-value 0.53
eGene Caudate basal ganglia
Cerebellum
Cortex
Frontal Cortex BA9
Hippocampus
Nucleus accumbens basal ganglia
Putamen basal ganglia
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs3769467 chr2 201205340 STON1 11037 1.349E-4 trans
rs3769461 chr2 201222657 STON1 11037 1.349E-4 trans
rs3772721 chr3 182763651 STON1 11037 0.14 trans
rs9851931 chr3 191826057 STON1 11037 0.03 trans
rs3777860 chr6 133756499 STON1 11037 0.18 trans
rs12665690 chr6 133759486 STON1 11037 0.18 trans
rs763641 chr11 123846625 STON1 11037 0.03 trans
rs4614855 chr19 3487326 STON1 11037 0.06 trans
rs4953593 2 48780022 STON1 ENSG00000243244.1 3.338E-7 0 22712 gtex_brain_putamen_basal
rs11125176 2 48780927 STON1 ENSG00000243244.1 9.678E-7 0 23617 gtex_brain_putamen_basal
rs6737732 2 48785276 STON1 ENSG00000243244.1 3.823E-7 0 27966 gtex_brain_putamen_basal
rs76033316 2 48786180 STON1 ENSG00000243244.1 3.811E-7 0 28870 gtex_brain_putamen_basal
rs200619386 2 48786182 STON1 ENSG00000243244.1 3.806E-7 0 28872 gtex_brain_putamen_basal
rs138564679 2 48786183 STON1 ENSG00000243244.1 3.799E-7 0 28873 gtex_brain_putamen_basal
rs12999304 2 48786743 STON1 ENSG00000243244.1 2.828E-7 0 29433 gtex_brain_putamen_basal
rs11681868 2 48787040 STON1 ENSG00000243244.1 5.817E-7 0 29730 gtex_brain_putamen_basal
rs2293274 2 48787134 STON1 ENSG00000243244.1 2.828E-7 0 29824 gtex_brain_putamen_basal
rs2293272 2 48787733 STON1 ENSG00000243244.1 4.774E-8 0 30423 gtex_brain_putamen_basal
rs2293270 2 48788000 STON1 ENSG00000243244.1 4.774E-8 0 30690 gtex_brain_putamen_basal
rs12992870 2 48789195 STON1 ENSG00000243244.1 1.787E-7 0 31885 gtex_brain_putamen_basal
rs6729860 2 48790727 STON1 ENSG00000243244.1 5.748E-7 0 33417 gtex_brain_putamen_basal
rs148704945 2 48790832 STON1 ENSG00000243244.1 3.166E-7 0 33522 gtex_brain_putamen_basal
rs13034063 2 48791553 STON1 ENSG00000243244.1 3.993E-7 0 34243 gtex_brain_putamen_basal
rs13014112 2 48792164 STON1 ENSG00000243244.1 4.741E-8 0 34854 gtex_brain_putamen_basal
rs6709043 2 48792443 STON1 ENSG00000243244.1 2.828E-7 0 35133 gtex_brain_putamen_basal
rs2177489 2 48792568 STON1 ENSG00000243244.1 4.774E-8 0 35258 gtex_brain_putamen_basal
rs6712592 2 48793113 STON1 ENSG00000243244.1 2.828E-7 0 35803 gtex_brain_putamen_basal
rs6741341 2 48793315 STON1 ENSG00000243244.1 4.774E-8 0 36005 gtex_brain_putamen_basal
rs2349098 2 48794283 STON1 ENSG00000243244.1 5.747E-7 0 36973 gtex_brain_putamen_basal
rs6727929 2 48795109 STON1 ENSG00000243244.1 1.062E-7 0 37799 gtex_brain_putamen_basal
rs13025488 2 48795800 STON1 ENSG00000243244.1 2.828E-7 0 38490 gtex_brain_putamen_basal
rs6732365 2 48796407 STON1 ENSG00000243244.1 2.611E-7 0 39097 gtex_brain_putamen_basal
rs12990079 2 48797923 STON1 ENSG00000243244.1 5.747E-7 0 40613 gtex_brain_putamen_basal
rs11681276 2 48798705 STON1 ENSG00000243244.1 2.828E-7 0 41395 gtex_brain_putamen_basal
rs11681426 2 48798996 STON1 ENSG00000243244.1 2.828E-7 0 41686 gtex_brain_putamen_basal
rs6712724 2 48799042 STON1 ENSG00000243244.1 2.753E-7 0 41732 gtex_brain_putamen_basal
rs13027618 2 48799975 STON1 ENSG00000243244.1 2.823E-7 0 42665 gtex_brain_putamen_basal
rs13010692 2 48800667 STON1 ENSG00000243244.1 2.828E-7 0 43357 gtex_brain_putamen_basal
rs13034951 2 48800886 STON1 ENSG00000243244.1 2.828E-7 0 43576 gtex_brain_putamen_basal
rs11676150 2 48802357 STON1 ENSG00000243244.1 5.758E-7 0 45047 gtex_brain_putamen_basal
rs11693429 2 48802476 STON1 ENSG00000243244.1 5.758E-7 0 45166 gtex_brain_putamen_basal
rs62135230 2 48802819 STON1 ENSG00000243244.1 1.034E-6 0 45509 gtex_brain_putamen_basal
rs200655510 2 48802896 STON1 ENSG00000243244.1 7.267E-7 0 45586 gtex_brain_putamen_basal
rs188314488 2 48802898 STON1 ENSG00000243244.1 1.026E-6 0 45588 gtex_brain_putamen_basal
rs62135231 2 48803491 STON1 ENSG00000243244.1 2.831E-7 0 46181 gtex_brain_putamen_basal
rs62135232 2 48803848 STON1 ENSG00000243244.1 2.83E-7 0 46538 gtex_brain_putamen_basal
rs62135233 2 48803932 STON1 ENSG00000243244.1 2.829E-7 0 46622 gtex_brain_putamen_basal
rs56111874 2 48804147 STON1 ENSG00000243244.1 2.816E-7 0 46837 gtex_brain_putamen_basal
rs55700200 2 48804179 STON1 ENSG00000243244.1 2.816E-7 0 46869 gtex_brain_putamen_basal
rs62135236 2 48804652 STON1 ENSG00000243244.1 2.984E-7 0 47342 gtex_brain_putamen_basal
rs66888174 2 48804776 STON1 ENSG00000243244.1 8.816E-8 0 47466 gtex_brain_putamen_basal
rs72824120 2 48805079 STON1 ENSG00000243244.1 2.831E-7 0 47769 gtex_brain_putamen_basal
rs13030948 2 48805294 STON1 ENSG00000243244.1 4.131E-7 0 47984 gtex_brain_putamen_basal
rs13031184 2 48805365 STON1 ENSG00000243244.1 2.827E-7 0 48055 gtex_brain_putamen_basal
rs6722556 2 48806235 STON1 ENSG00000243244.1 2.838E-7 0 48925 gtex_brain_putamen_basal
rs6741677 2 48807170 STON1 ENSG00000243244.1 2.828E-7 0 49860 gtex_brain_putamen_basal
rs2103112 2 48807283 STON1 ENSG00000243244.1 2.828E-7 0 49973 gtex_brain_putamen_basal
rs2882084 2 48807331 STON1 ENSG00000243244.1 2.828E-7 0 50021 gtex_brain_putamen_basal
rs55641971 2 48807405 STON1 ENSG00000243244.1 2.828E-7 0 50095 gtex_brain_putamen_basal
rs17039250 2 48807796 STON1 ENSG00000243244.1 2.828E-7 0 50486 gtex_brain_putamen_basal
rs3828340 2 48807976 STON1 ENSG00000243244.1 4.774E-8 0 50666 gtex_brain_putamen_basal
rs940389 2 48808152 STON1 ENSG00000243244.1 5.823E-7 0 50842 gtex_brain_putamen_basal
rs3749144 2 48808882 STON1 ENSG00000243244.1 2.828E-7 0 51572 gtex_brain_putamen_basal
rs3749145 2 48808898 STON1 ENSG00000243244.1 2.828E-7 0 51588 gtex_brain_putamen_basal
rs3792236 2 48809873 STON1 ENSG00000243244.1 2.828E-7 0 52563 gtex_brain_putamen_basal
rs12992755 2 48810117 STON1 ENSG00000243244.1 1.787E-7 0 52807 gtex_brain_putamen_basal
rs13016899 2 48810408 STON1 ENSG00000243244.1 5.829E-7 0 53098 gtex_brain_putamen_basal
rs11680574 2 48810616 STON1 ENSG00000243244.1 2.828E-7 0 53306 gtex_brain_putamen_basal
rs6742725 2 48811081 STON1 ENSG00000243244.1 1.683E-7 0 53771 gtex_brain_putamen_basal
rs6757847 2 48811149 STON1 ENSG00000243244.1 2.822E-7 0 53839 gtex_brain_putamen_basal
rs10495953 2 48811854 STON1 ENSG00000243244.1 7.085E-8 0 54544 gtex_brain_putamen_basal
rs4566410 2 48811883 STON1 ENSG00000243244.1 4.133E-7 0 54573 gtex_brain_putamen_basal
rs11693559 2 48811948 STON1 ENSG00000243244.1 4.133E-7 0 54638 gtex_brain_putamen_basal
rs11693691 2 48812064 STON1 ENSG00000243244.1 4.343E-7 0 54754 gtex_brain_putamen_basal
rs11678306 2 48812131 STON1 ENSG00000243244.1 4.343E-7 0 54821 gtex_brain_putamen_basal
rs55858189 2 48812554 STON1 ENSG00000243244.1 7.077E-8 0 55244 gtex_brain_putamen_basal
rs11683611 2 48812560 STON1 ENSG00000243244.1 4.133E-7 0 55250 gtex_brain_putamen_basal
rs3792237 2 48812828 STON1 ENSG00000243244.1 4.133E-7 0 55518 gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
OAF 0.88 0.88
GLUL 0.85 0.78
MERTK 0.84 0.84
GRIN2C 0.82 0.85
ACSBG1 0.81 0.82
SLC25A18 0.81 0.85
HSD17B6 0.81 0.84
SELENBP1 0.80 0.85
SLC13A5 0.80 0.82
SLCO1C1 0.79 0.80
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
C6orf168 -0.60 -0.73
MLLT11 -0.58 -0.75
SPATS2 -0.58 -0.74
RAB35 -0.58 -0.75
MED19 -0.58 -0.74
DYNC1LI1 -0.57 -0.69
NOP56 -0.57 -0.71
PPP3CC -0.57 -0.75
PREP -0.57 -0.69
EIF4E2 -0.57 -0.74

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG BASAL TRANSCRIPTION FACTORS 36 24 All SZGR 2.0 genes in this pathway
HOOI ST7 TARGETS DN 123 78 All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663 425 All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS DN 310 188 All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP 424 268 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830 547 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN 298 200 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 6HR DN 160 101 All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER T4 94 69 All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P4 100 62 All SZGR 2.0 genes in this pathway
RUIZ TNC TARGETS UP 153 107 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518 299 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN 668 419 All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE UP 242 159 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 6HR DN 91 56 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN 505 328 All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1 467 251 All SZGR 2.0 genes in this pathway