Gene Page:ABHD2

Summary?
GeneID 11057
Symbol ABHD2
Synonyms HS1-2|LABH2|PHPS1-2
Description abhydrolase domain containing 2
Reference MIM:612196|HGNC:HGNC:18717|Ensembl:ENSG00000140526|HPRD:09791|Vega:OTTHUMG00000148684
Gene type protein-coding
Map location 15q26.1
Pascal p-value 0.007

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
Expression Meta-analysis of gene expression Pvalue: 2.052

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
PALM2-AKAP2 0.97 0.98
PHACTR2 0.87 0.76
PLCB4 0.85 0.74
AHNAK2 0.85 0.78
PAQR9 0.84 0.79
PTPN4 0.84 0.75
RASSF3 0.84 0.64
KCNH5 0.82 0.71
STS 0.82 0.80
RORA 0.82 0.56
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
C1orf61 -0.40 -0.61
C2orf84 -0.39 -0.45
SAT1 -0.37 -0.51
AF347015.21 -0.37 -0.49
C1orf54 -0.36 -0.54
S100A13 -0.36 -0.46
SYCP3 -0.35 -0.50
C8orf59 -0.35 -0.42
CBR3 -0.35 -0.46
FXYD1 -0.35 -0.43

Section III. Gene Ontology annotation

Molecular function 去term Evidence Neuro keywords PubMed ID
去:0003674 molecular_function ND -
去:0004091 carboxylesterase activity IEA -
去:0016787 hydrolase activity IEA -
Biological process 去term Evidence Neuro keywords PubMed ID
去:0009611 response to wounding IEA -
去:0008150 biological_process ND -
去:0030336 negative regulation of cell migration IEA -
Cellular component 去term Evidence Neuro keywords PubMed ID
去:0005634 nucleus IDA 18029348
去:0005730 nucleolus IDA 18029348
去:0005737 cytoplasm IDA 18029348
去:0016020 membrane IEA -
去:0016021 integral to membrane NAS -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0基因通路 Info
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL UP 285 181 All SZGR 2.0 genes in this pathway
ZHONG RESPONSE TO AZACITIDINE AND TSA UP 183 119 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579 346 All SZGR 2.0 genes in this pathway
DEURIG T细胞PROLYMPHOCYTIC白血病 368 234 All SZGR 2.0 genes in this pathway
JAEGER METASTASIS DN 258 141 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 UP 380 236 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP 418 263 All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 UP 341 197 All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER GRADES 1 2 UP 137 84 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 All SZGR 2.0 genes in this pathway
去ZGIT ESR1 TARGETS DN 781 465 All SZGR 2.0 genes in this pathway
WANG BARRETTS ESOPHAGUS UP 51 27 All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS LUMINAL 326 213 All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS DN 193 112 All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING UP 108 69 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 480 HELA 164 118 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER ACOX1 UP 64 40 All SZGR 2.0 genes in this pathway
NELSON RESPONSE TO ANDROGEN UP 86 61 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER CIPROFIBRATE UP 60 42 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER DENA UP 60 40 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD1 AND CD2 DN 51 32 All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED UP 183 111 All SZGR 2.0 genes in this pathway
HENDRICKS SMARCA4 TARGETS UP 56 35 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR UP 148 96 All SZGR 2.0 genes in this pathway
KRIGE应对日本东星软件DOSTAT 6HR UP 953 554 All SZGR 2.0 genes in this pathway
KRIGE应对日本东星软件DOSTAT 24HR UP 783 442 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022 619 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
YEGNASUBRAMANIAN PROSTATE CANCER 128 60 All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR DN 191 123 All SZGR 2.0 genes in this pathway
TOYOTA TARGETS OF MIR34B AND MIR34C 463 262 All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G1 DN 40 26 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S3 266 180 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA DN 267 160 All SZGR 2.0 genes in this pathway
MARTENS BOUND BY PML RARA FUSION 456 287 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 6HR UP 229 149 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR UP 324 193 All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS DN 229 135 All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS DN 315 215 All SZGR 2.0 genes in this pathway
SUMI HNF4A TARGETS 34 14 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682 433 All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824 528 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658 397 All SZGR 2.0 genes in this pathway
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF 516 308 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-1/206 6553 6559 m8 hsa-miR-1 UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZ UGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613 AGGAAUGUUCCUUCUUUGCC
miR-129-5p 6079 6085 m8 hsa-miR-129brain CUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5p CUUUUUGCGGUCUGGGCUUGCU
miR-134 6154 6161 1A,m8 hsa-miR-134brain UGUGACUGGUUGACCAGAGGG
miR-143 5801 5807 m8 hsa-miR-143brain UGAGAUGAAGCACUGUAGCUCA
miR-17-5p/20/93.mr/106/519.d 1946 1953 1A,m8 hsa-miR-17-5p CAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519d CAAAGUGCCUCCCUUUAGAGUGU
hsa-miR-17-5p CAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519d CAAAGUGCCUCCCUUUAGAGUGU
miR-186 5083 5090 1A,m8 hsa-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
miR-205 5736 5742 1A hsa-miR-205 UCCUUCAUUCCACCGGAGUCUG
miR-214 4480 4486 m8 hsa-miR-214brain ACAGCAGGCACAGACAGGCAG
miR-219 1762 1769 1A,m8 hsa-miR-219brain UGAUUGUCCAAACGCAAUUCU
miR-24 5786 5792 m8 hsa-miR-24SZ UGGCUCAGUUCAGCAGGAACAG
miR-26 1450 1457 1A,m8 hsa-miR-26abrain UUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZ UUCAAGUAAUUCAGGAUAGGUU
miR-27 6289 6295 1A hsa-miR-27abrain UUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrain UUCACAGUGGCUAAGUUCUGC
miR-30-5p 6102 6108 m8 hsa-miR-30a-5p UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
miR-326 4117 4123 1A hsa-miR-326 CCUCUGGGCCCUUCCUCCAG
miR-33 6724 6731 1A,m8 hsa-miR-33 GUGCAUUGUAGUUGCAUUG
hsa-miR-33b GUGCAUUGCUGUUGCAUUGCA
miR-330 332 338 m8 hsa-miR-330brain GCAAAGCACACGGCCUGCAGAGA
miR-450 6079 6085 1A hsa-miR-450 UUUUUGCGAUGUGUUCCUAAUA
miR-485-5p 626 632 m8 hsa-miR-485-5p AGAGGCUGGCCGUGAUGAAUUC
miR-488 3987 3993 1A hsa-miR-488 CCCAGAUAAUGGCACUCUCAA
miR-494 62 68 1A hsa-miR-494brain UGAAACAUACACGGGAAACCUCUU
miR-495 5168 5174 m8 hsa-miR-495brain AAACAAACAUGGUGCACUUCUUU
miR-539 5840 5846 m8 hsa-miR-539 GGAGAAAUUAUCCUUGGUGUGU