Gene Page:DNAJB4

Summary?
GeneID 11080
Symbol DNAJB4
Synonyms DNAJW|DjB4|HLJ1
Description DnaJ heat shock protein family (Hsp40) member B4
Reference MIM:611327|HGNC:HGNC:14886|HPRD:07486|
Gene type protein-coding
Map location 1p31.1
Pascal p-value 0.047
Sherlock p-value 0.543
Fetal beta -0.834
DMG 1 (# studies)
eGene Myers' cis & trans
Support CompositeSet

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.02692
Expression Meta-analysis of gene expression Pvalue: 1.445

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg25846022 1 78444909 DNAJB4 6.39E-10 -0.011 9.42E-7 DMG:Jaffe_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs1879328 chr3 46568156 DNAJB4 11080 0.15 trans
rs13350793 0 DNAJB4 11080 0.18 trans
rs1009417 chr5 74568133 DNAJB4 11080 0.1 trans
rs12660028 chr5 74605501 DNAJB4 11080 0.04 trans
rs1423526 chr5 74606172 DNAJB4 11080 0.04 trans
rs6877840 chr5 74611523 DNAJB4 11080 0.15 trans
rs10848708 chr12 2931451 DNAJB4 11080 0.06 trans
rs2286601 chr12 2932176 DNAJB4 11080 0.14 trans
rs8120542 chr20 24395092 DNAJB4 11080 0.05 trans
rs8114637 chr20 24395207 DNAJB4 11080 0.05 trans
rs4536719 chr20 24397114 DNAJB4 11080 0.17 trans
rs9974024 chr20 24397274 DNAJB4 11080 0.05 trans
rs6515493 chr20 24401635 DNAJB4 11080 0.05 trans
rs6049703 chr20 24432425 DNAJB4 11080 0.14 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
GPRC5B 0.94 0.88
LDB3 0.93 0.91
C10orf90 0.93 0.94
EFHD1 0.93 0.93
C5orf4 0.92 0.91
ERBB3 0.92 0.93
C11orf9 0.91 0.91
AC022100.1 0.91 0.87
PLEKHH1 0.91 0.78
ATPGD1 0.91 0.92
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MED19 -0.60 -0.76
NKIRAS2 -0.60 -0.68
NR2C2AP -0.60 -0.78
POLB -0.59 -0.78
TRNAU1AP -0.59 -0.74
HN1 -0.58 -0.73
DUSP12 -0.58 -0.73
ALKBH2 -0.58 -0.78
ING4 -0.58 -0.73
IFT52 -0.58 -0.75

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0031072 heat shock protein binding IEA -
GO:0051082 unfolded protein binding TAS 9546042
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0006457 protein folding IEA -
GO:0006986 response to unfolded protein TAS 9546042
GO:0009408 response to heat TAS 9546042

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0基因通路 Info
GARY CD5 TARGETS DN 431 263 All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP 423 283 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN 455 304 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN 460 312 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN 459 276 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 8HR UP 164 122 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508 354 All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER DN 232 154 All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP 239 157 All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 5 147 89 All SZGR 2.0 genes in this pathway
多尔STAT3TARGETS DN 50 34 All SZGR 2.0 genes in this pathway
AMUNDSON RESPONSE TO ARSENITE 217 143 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 AND HIF1A UP 142 104 All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769 437 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648 385 All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893 528 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 UP 256 159 All SZGR 2.0 genes in this pathway
SANA TNF SIGNALING DN 90 57 All SZGR 2.0 genes in this pathway
SHEPARD BMYB MORPHOLINO UP 205 126 All SZGR 2.0 genes in this pathway
ADDYA红细胞不同ENTIATION BY HEMIN 73 47 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830 547 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS PEAK AT 2HR 51 36 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 1 33 24 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022 619 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
MARSON FOXP3 TARGETS STIMULATED DN 11 9 All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION DN 105 67 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN 292 189 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281 179 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BONE DN 315 197 All SZGR 2.0 genes in this pathway
乳腺癌萧述三腔的DN 564 326 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP 648 398 All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING 510 309 All SZGR 2.0 genes in this pathway
PODAR RESPONSE TO ADAPHOSTIN UP 147 98 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D UP 139 95 All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS UP 395 249 All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS DN 442 275 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518 299 All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721 492 All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE S 162 86 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504 321 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898 516 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS UP 279 155 All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 PARTIAL 160 106 All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM A 182 108 All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 6HR UP 166 97 All SZGR 2.0 genes in this pathway
GHANDHI BYSTANDER IRRADIATION UP 86 54 All SZGR 2.0 genes in this pathway
WARTERS RESPONSE TO IR SKIN 83 44 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725 838 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-24* 151 157 1A hsa-miR-189 GUGCCUACUGAGCUGAUAUCAGU
miR-30-3p 36 43 1A,m8 hsa-miR-30a-3p CUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3p CUUUCAGUCGGAUGUUUACAGC
miR-539 213 219 m8 hsa-miR-539 GGAGAAAUUAUCCUUGGUGUGU