Gene Page:ADAMTS5

Summary?
GeneID 11096
Symbol ADAMTS5
Synonyms ADAM-TS 11|ADAM-TS 5|ADAM-TS5|ADAMTS-11|ADAMTS-5|ADAMTS11|ADMP-2
Description ADAM metallopeptidase with thrombospondin type 1 motif 5
Reference MIM:605007|HGNC:HGNC:221|Ensembl:ENSG00000154736|HPRD: 05420|Vega:OTTHUMG00000078686
Gene type protein-coding
Map location 21q21.3
Pascal p-value 0.467
Fetal beta 0.669
DMG 1 (# studies)
eGene Cerebellar Hemisphere
Cerebellum
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg13601496 21 28339487 ADAMTS5 5.3E-8 -0.006 1.38E-5 DMG:Jaffe_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs6687849 chr1 175904808 ADAMTS5 11096 0 trans
rs2481653 chr1 176044120 ADAMTS5 11096 0.01 trans
rs2502827 chr1 176044216 ADAMTS5 11096 8.51E-6 trans
rs12405921 chr1 206695730 ADAMTS5 11096 0.02 trans
rs17572651 chr1 218943612 ADAMTS5 11096 0.01 trans
rs882011 chr2 22711668 ADAMTS5 11096 0.12 trans
rs16829545 chr2 151977407 ADAMTS5 11096 1.079E-7 trans
rs3845734 chr2 171125572 ADAMTS5 11096 8.235E-5 trans
rs7584986 chr2 184111432 ADAMTS5 11096 3.943E-12 trans
rs6807632 chr3 111395567 ADAMTS5 11096 0 trans
rs7681432 chr4 56162058 ADAMTS5 11096 0.04 trans
rs7664496 chr4 56252823 ADAMTS5 11096 0.15 trans
snp_a-2078569 0 ADAMTS5 11096 0.03 trans
rs17762315 chr5 76807576 ADAMTS5 11096 0.02 trans
rs10491487 chr5 80323367 ADAMTS5 11096 0.01 trans
rs1368303 chr5 147672388 ADAMTS5 11096 3.288E-6 trans
rs4872540 chr8 22598980 ADAMTS5 11096 0.2 trans
rs6989594 chr8 126303866 ADAMTS5 11096 0.07 trans
rs11139334 chr9 84209393 ADAMTS5 11096 0.07 trans
rs17263352 chr9 124811572 ADAMTS5 11096 0.02 trans
rs457696 chr13 32581313 ADAMTS5 11096 0.18 trans
rs7996604 chr13 42224412 ADAMTS5 11096 0.15 trans
snp_a-1880548 0 ADAMTS5 11096 0.14 trans
rs1629937 chr14 77059671 ADAMTS5 11096 0.06 trans
rs17104720 chr14 77127308 ADAMTS5 11096 1.159E-5 trans
rs17104722 chr14 77138109 ADAMTS5 11096 0.18 trans
rs17104782 chr14 77156735 ADAMTS5 11096 0.18 trans
rs6574467 chr14 79179744 ADAMTS5 11096 0.17 trans
rs10146003 chr14 79191170 ADAMTS5 11096 0.17 trans
rs16955618 chr15 29937543 ADAMTS5 11096 1.216E-25 trans
snp_a-1830894 0 ADAMTS5 11096 0 trans
rs3743068 chr15 79047284 ADAMTS5 11096 0.05 trans
rs17823633 chr17 68851458 ADAMTS5 11096 0.04 trans
rs17070739 chr18 60819382 ADAMTS5 11096 0.13 trans
rs17085767 chr18 69839397 ADAMTS5 11096 0.05 trans
rs749043 chr20 46995700 ADAMTS5 11096 0.02 trans
rs5955025 chrX 142542997 ADAMTS5 11096 0.18 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
相约: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
LIU PROSTATE CANCER DN 481 290 All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP 255 177 All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 UP 408 247 All SZGR 2.0 genes in this pathway
TURASHVILI BREAST DUCTAL CARCINOMA VS DUCTAL NORMAL DN 198 110 All SZGR 2.0 genes in this pathway
TURASHVILI BREAST LOBULAR CARCINOMA VS LOBULAR NORMAL UP 94 59 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN 460 312 All SZGR 2.0 genes in this pathway
RODRIGUES NTN1 TARGETS DN 158 102 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431 237 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION DN 329 219 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
TANG SENESCENCE TP53 TARGETS UP 33 20 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 4 5WK UP 271 175 All SZGR 2.0 genes in this pathway
BEGUM TARGETS OF PAX3 FOXO1 FUSION UP 60 45 All SZGR 2.0 genes in this pathway
WONG ENDMETRIUM CANCER DN 82 53 All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174 695 All SZGR 2.0 genes in this pathway
LIEN BREAST CARCINOMA METAPLASTIC 35 25 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 All SZGR 2.0 genes in this pathway
LIAO METASTASIS 539 324 All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062 725 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS EARLY PROGENITOR 532 309 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830 547 All SZGR 2.0 genes in this pathway
《图片报》极品致癌签名 261 166 All SZGR 2.0 genes in this pathway
HUPER BREAST BASAL VS LUMINAL DN 59 44 All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR DN 185 116 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN 457 302 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 491 319 All SZGR 2.0 genes in this pathway
HOELZEL NF1 TARGETS DN 115 73 All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS DN 229 135 All SZGR 2.0 genes in this pathway
KATSANOU ELAVL1 TARGETS UP 169 105 All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS UP 135 96 All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR DN 244 157 All SZGR 2.0 genes in this pathway
NABA ECM REGULATORS 238 125 All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753 411 All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028 559 All SZGR 2.0 genes in this pathway