Gene Page:PRSS23

Summary?
GeneID 11098
Symbol PRSS23
Synonyms SIG13|SPUVE|ZSIG13
Description protease, serine 23
Reference HGNC:HGNC:14370|Ensembl:ENSG00000150687|HPRD:07149|Vega:OTTHUMG00000167226
Gene type protein-coding
Map location 11q14.1
Pascal p-value 0.189
Sherlock p-value 0.108
Fetal beta 1.186
eGene Myers' cis & trans
Meta

Gene in Data Sources
基因集名称 Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs6897181 chr5 6894506 PRSS23 11098 0.06 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MUM1L1 0.75 0.56
SYTL2 0.70 0.72
AK5 0.70 0.60
ALDH1A3 0.70 0.72
RASGRF2 0.69 0.64
MPP7 0.69 0.56
SYNPO2 0.69 0.69
APOL2 0.69 0.73
COBL 0.69 0.71
TACC1 0.69 0.75
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
BCL7C -0.48 -0.62
C6orf48 -0.47 -0.63
RPL36 -0.45 -0.66
RPL12 -0.45 -0.62
AC006276.2 -0.45 -0.58
RPLP1 -0.45 -0.62
C1orf86 -0.45 -0.58
RPS9 -0.45 -0.64
RPS23 -0.44 -0.65
RPS18 -0.44 -0.65

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0004252 serine-type endopeptidase activity IEA glutamate (GO term level: 7) -
GO:0008233 peptidase activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006508 proteolysis IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005576 extracellular region IEA -
GO:0005634 nucleus IDA 11256614

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ACTG1 ACT | ACTG | DFNA20 | DFNA26 actin, gamma 1 Two-hybrid BioGRID 16169070
B2M - beta-2-microglobulin Two-hybrid BioGRID 16169070
CHP SLC9A1BP calcium binding protein P22 Two-hybrid BioGRID 16169070
EFNA3 EFL2 | EPLG3 | Ehk1-L | LERK3 ephrin-A3 Two-hybrid BioGRID 16169070
FXR1 - fragile X mental retardation, autosomal homolog 1 Two-hybrid BioGRID 16169070
GRK6 FLJ32135 | GPRK6 G protein-coupled receptor kinase 6 Two-hybrid BioGRID 16169070
HSPA4 APG-2 | HS24/P52 | MGC131852 | RY | hsp70 | hsp70RY heat shock 70kDa protein 4 Two-hybrid BioGRID 16169070
LOC158345 - hypothetical LOC158345 Two-hybrid BioGRID 16169070
MAPK8IP2 IB2 | JIP2 | PRKM8IPL mitogen-activated protein kinase 8 interacting protein 2 Two-hybrid BioGRID 16169070
NCAPD3 CAP-D3 | FLJ42888 | KIAA0056 | MGC104671 | hCAP-D3 | hHCP-6 | hcp-6 non-SMC condensin II complex, subunit D3 Two-hybrid BioGRID 16169070
NIPBL CDLS | CDLS1 | DKFZp434L1319 | FLJ11203 | FLJ12597 | FLJ13354 | FLJ13648 | FLJ44854 | IDN3 | IDN3-B Nipped-B homolog (Drosophila) Two-hybrid BioGRID 16169070
NOC4L MGC3162 | NOC4 nucleolar complex associated 4 homolog (S. cerevisiae) Two-hybrid BioGRID 16169070
ODF2L KIAA1229 | MGC111060 |RP5-977L11.1 | dJ977L11.1 outer dense fiber of sperm tails 2-like Two-hybrid BioGRID 16169070
PDDC1 FLJ34283 | FLJ35497 | MGC131881 | MGC138350 Parkinson disease 7 domain containing 1 Two-hybrid BioGRID 16169070
PDPK1 MGC20087 | MGC35290 | PDK1 | PRO0461 3-phosphoinositide dependent protein kinase-1 Two-hybrid BioGRID 16169070
PHF23 FLJ16355 | FLJ22884 | MGC2941 | hJUNE-1b PHD finger protein 23 Two-hybrid BioGRID 16169070
PPIA CYPA | CYPH | MGC117158 | MGC12404 | MGC23397 peptidylprolyl isomerase A (cyclophilin A) Two-hybrid BioGRID 16169070
RACGAP1 HsCYK-4 | ID-GAP | MgcRacGAP Rac GTPase activating protein 1 Two-hybrid BioGRID 16169070
RECQL4 RECQ4 RecQ protein-like 4 Two-hybrid BioGRID 16169070
SHMT1 CSHMT | MGC15229 | MGC24556 | SHMT serine hydroxymethyltransferase 1 (soluble) Two-hybrid BioGRID 16169070
SLC25A6 AAC3 | ANT3 | ANT3Y | MGC17525 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 Two-hybrid BioGRID 16169070
TCF12 HEB | HTF4 | HsT17266 | bHLHb20 transcription factor 12 Two-hybrid BioGRID 16169070
TMEM222 C1orf160 | DKFZp564D0478 | MGC111002 transmembrane protein 222 Two-hybrid BioGRID 16169070
TRAPPC4 CGI-104 | HSPC172 | PTD009 | SBDN | SYNBINDIN | TRS23 trafficking protein particle complex 4 Two-hybrid BioGRID 16169070


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL UP 285 181 All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN 481 290 All SZGR 2.0 genes in this pathway
LIU SOX4 TARGETS UP 137 94 All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA DN 349 157 All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663 425 All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS UP 290 177 All SZGR 2.0 genes in this pathway
SMIRNOV CIRCULATING ENDOTHELIOCYTES IN CANCER UP 158 103 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D UP 182 110 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D UP 157 91 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC UP 185 126 All SZGR 2.0 genes in this pathway
DITTMER PTHLH TARGETS UP 112 68 All SZGR 2.0 genes in this pathway
LEE NEURAL CREST STEM CELL DN 118 79 All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP 557 331 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION DN 329 219 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781 465 All SZGR 2.0 genes in this pathway
HAHTOLA SEZARY SYNDROM DN 42 26 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508 354 All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443 294 All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS DN 142 95 All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION CDC25 DN 153 100 All SZGR 2.0 genes in this pathway
BERENJENO ROCK SIGNALING NOT VIA RHOA DN 48 34 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552 347 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION UP 211 136 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 5 6WK UP 116 68 All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 2 127 92 All SZGR 2.0 genes in this pathway
HERNANDEZ ABERRANT MITOSIS BY DOCETACEL 2NM UP 81 57 All SZGR 2.0 genes in this pathway
HERNANDEZ MITOTIC ARREST BY DOCETAXEL 2 UP 64 45 All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM1 229 137 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN 637 377 All SZGR 2.0 genes in this pathway
GUENTHER GROWTH SPHERICAL VS ADHERENT DN 26 19 All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893 528 All SZGR 2.0 genes in this pathway
CERVERA SDHB TARGETS 2 114 76 All SZGR 2.0 genes in this pathway
CERVERA SDHB TARGETS 1 UP 118 66 All SZGR 2.0 genes in this pathway
FRASOR RESPONSE TO ESTRADIOL UP 37 28 All SZGR 2.0 genes in this pathway
SANA RESPONSE TO IFNG DN 85 56 All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475 313 All SZGR 2.0 genes in this pathway
LEI MYB TARGETS 318 215 All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS DN 371 218 All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE UP 249 170 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR DN 148 102 All SZGR 2.0 genes in this pathway
DELASERNA MYOD TARGETS UP 89 51 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 8 86 57 All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER BRCA1 VS BRCA2 163 113 All SZGR 2.0 genes in this pathway
TSENG IRS1 TARGETS UP 113 71 All SZGR 2.0 genes in this pathway
TSENG ADIPOGENIC POTENTIAL UP 30 19 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528 324 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 4 307 185 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS RESPONSIVE TO ESTROGEN DN 41 26 All SZGR 2.0 genes in this pathway
KYNG ENVIRONMENTAL STRESS RESPONSE NOT BY GAMMA IN OLD 31 19 All SZGR 2.0 genes in this pathway
KYNG ENVIRONMENTAL STRESS RESPONSE NOT BY GAMMA IN WS 33 22 All SZGR 2.0 genes in this pathway
KYNG ENVIRONMENTAL STRESS RESPONSE NOT BY UV IN OLD 25 18 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN 195 135 All SZGR 2.0 genes in this pathway
KYNG ENVIRONMENTAL STRESS RESPONSE UP 56 41 All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE DN 258 160 All SZGR 2.0 genes in this pathway
MASSARWEH RESPONSE TO ESTRADIOL 61 47 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701 446 All SZGR 2.0 genes in this pathway
BASSO HAIRY CELL LEUKEMIA DN 80 66 All SZGR 2.0 genes in this pathway
BRUECKNER TARGETS OF MIRLET7A3 DN 78 49 All SZGR 2.0 genes in this pathway
布卢姆应对SALIRASIB DN 342 220 All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS DN 138 92 All SZGR 2.0 genes in this pathway
MOOTHA PGC 420 269 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA D UP 89 62 All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR UP 293 203 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN 668 419 All SZGR 2.0 genes in this pathway
STEIN ESR1 TARGETS 85 55 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA PCA3 UP 80 54 All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721 492 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 6 75 48 All SZGR 2.0 genes in this pathway
NAKAMURA ADIPOGENESIS EARLY UP 66 44 All SZGR 2.0 genes in this pathway
NAKAMURA ADIPOGENESIS EARLY DN 38 27 All SZGR 2.0 genes in this pathway
NAKAMURA ADIPOGENESIS LATE UP 104 67 All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT 567 365 All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS UP 295 155 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 6HR UP 229 149 All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS NOT VIA AKT1 UP 211 131 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549 316 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137 655 All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS DN 315 215 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745 475 All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824 528 All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN 784 464 All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38 337 236 All SZGR 2.0 genes in this pathway