Gene Page:STRAP
Summary?
| GeneID | 11171 |
| Symbol | STRAP |
| Synonyms | MAWD|PT-WD|UNRIP |
| Description | serine/threonine kinase receptor associated protein |
| Reference | MIM:605986|HGNC:HGNC:30796|Ensembl:ENSG00000023734|HPRD:05816|Vega:OTTHUMG00000168791 |
| Gene type | protein-coding |
| Map location | 12p12.3 |
| Pascal p-value | 0.73 |
| Sherlock p-value | 0.417 |
| Fetal beta | -0.456 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| DDX24 | 0.90 | 0.84 |
| SRP68 | 0.90 | 0.88 |
| BCAS3 | 0.88 | 0.83 |
| KIAA0652 | 0.88 | 0.82 |
| MFN2 | 0.88 | 0.85 |
| VPS11 | 0.88 | 0.83 |
| PRPF19 | 0.87 | 0.83 |
| OTUD5 | 0.87 | 0.79 |
| NARS | 0.86 | 0.83 |
| ALKBH5 | 0.86 | 0.83 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.21 | -0.76 | -0.59 |
| MT-CO2 | -0.69 | -0.54 |
| AF347015.31 | -0.68 | -0.55 |
| IL32 | -0.67 | -0.57 |
| AF347015.8 | -0.67 | -0.52 |
| HIGD1B | -0.65 | -0.52 |
| NOSTRIN | -0.65 | -0.50 |
| AF347015.2 | -0.65 | -0.46 |
| MT-CYB | -0.64 | -0.50 |
| AF347015.18 | -0.64 | -0.51 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| GH1 | GH | GH-N | GHN | hGH-N | growth hormone 1 | Affinity Capture-MS | BioGRID | 17353931 |
| GSK3B | - | glycogen synthase kinase 3 beta | Affinity Capture-MS | BioGRID | 17353931 |
| LSM10 | MGC15749 | MST074 | MSTP074 | LSM10, U7 small nuclear RNA associated | Affinity Capture-MS | BioGRID | 12975319 |
| PBLD | FLJ14767 | FLJ35507 | MAWBP | MAWDBP | phenazine biosynthesis-like protein domain containing | - | HPRD,BioGRID | 11355021 |
| RNPS1 | E5.1 | MGC117332 | RNA binding protein S1, serine-rich domain | Affinity Capture-MS | BioGRID | 17353931 |
| SMAD2 | JV18 | JV18-1 | MADH2 | MADR2 | MGC22139 | MGC34440 | hMAD-2 | hSMAD2 | SMAD家庭成员2 | - | HPRD,BioGRID | 10757800 |
| SMAD3 | DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396 | SMAD家庭成员3 | - | HPRD,BioGRID | 10757800 |
| SMAD6 | HsT17432 | MADH6 | MADH7 | SMAD family member 6 | - | HPRD,BioGRID | 10757800 |
| SMAD7 | CRCS3 | FLJ16482 | MADH7 | MADH8 | SMAD family member 7 | - | HPRD,BioGRID | 10757800 |
| STRAP | MAWD | PT-WD | UNRIP | serine/threonine kinase receptor associated protein | - | HPRD,BioGRID | 10757800 |
| TGFBR1 | AAT5 | ACVRLK4 | ALK-5 | ALK5 | LDS1A | LDS2A | SKR4 | TGFR-1 | transforming growth factor, beta receptor 1 | T-beta-R1 interacts with STRAP. This interaction was modeled on a demonstrated interaction between T-beta-R1 and STRAP both from unspecified species. | BIND | 15761148 |
| TGFBR1 | AAT5 | ACVRLK4 | ALK-5 | ALK5 | LDS1A | LDS2A | SKR4 | TGFR-1 | transforming growth factor, beta receptor 1 | - | HPRD,BioGRID | 9856985 |
| TGFBR2 | AAT3 | FAA3 | LDS1B | LDS2B | MFS2 | RIIC | TAAD2 | TGFR-2 | TGFbeta-RII | transforming growth factor, beta receptor II (70/80kDa) | - | HPRD,BioGRID | 9856985 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PID TGFBR PATHWAY | 55 | 38 | All SZGR 2.0 genes in this pathway |
| REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | 23 | 13 | All SZGR 2.0 genes in this pathway |
| REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS | 26 | 16 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX | 63 | 42 | All SZGR 2.0 genes in this pathway |
| DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | 1382 | 904 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA DN | 1375 | 806 | All SZGR 2.0 genes in this pathway |
| SCHLOSSER SERUM RESPONSE DN | 712 | 443 | All SZGR 2.0 genes in this pathway |
| JAZAG TGFB1 SIGNALING UP | 108 | 69 | All SZGR 2.0 genes in this pathway |
| CHEOK RESPONSE TO HD MTX DN | 24 | 18 | All SZGR 2.0 genes in this pathway |
| FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN | 546 | 351 | All SZGR 2.0 genes in this pathway |
| PENG GLUTAMINE DEPRIVATION DN | 337 | 230 | All SZGR 2.0 genes in this pathway |
| YU MYC TARGETS UP | 42 | 26 | All SZGR 2.0 genes in this pathway |
| LI WILMS TUMOR VS FETAL KIDNEY 1 DN | 163 | 115 | All SZGR 2.0 genes in this pathway |
| WANG TARGETS OF MLL CBP FUSION DN | 45 | 31 | All SZGR 2.0 genes in this pathway |
| PAL PRMT5 TARGETS UP | 203 | 135 | All SZGR 2.0 genes in this pathway |
| MONNIER POSTRADIATION TUMOR ESCAPE UP | 393 | 244 | All SZGR 2.0 genes in this pathway |
| ZHANG BREAST CANCER PROGENITORS UP | 425 | 253 | All SZGR 2.0 genes in this pathway |
| WANG TUMOR INVASIVENESS UP | 374 | 247 | All SZGR 2.0 genes in this pathway |
| MILI PSEUDOPODIA HAPTOTAXIS UP | 518 | 299 | All SZGR 2.0 genes in this pathway |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 11 | 103 | 68 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS DN | 1972 | 1213 | All SZGR 2.0 genes in this pathway |
| BAKKER FOXO3 TARGETS DN | 187 | 109 | All SZGR 2.0 genes in this pathway |
| LEE BMP2 TARGETS DN | 882 | 538 | All SZGR 2.0 genes in this pathway |
| FEVR CTNNB1 TARGETS DN | 553 | 343 | All SZGR 2.0 genes in this pathway |