创e Page:MAP4K1
Summary?
| 创eID | 11184 |
| Symbol | MAP4K1 |
| Synonyms | HPK1 |
| Description | mitogen-activated protein kinase kinase kinase kinase 1 |
| Reference | MIM:601983|HGNC:HGNC:6863|Ensembl:ENSG00000104814|HPRD:03583|Vega:OTTHUMG00000180863 |
| 创e type | protein-coding |
| Map location | 19q13.1-q13.4 |
| Pascal p-value | 0.038 |
| Sherlock p-value | 0.008 |
| Fetal beta | -0.726 |
| eGene | Hypothalamus Myers' cis & trans |
创e in Data Sources
| 创e set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | 创ome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
eQTL annotation| SNP ID | Chromosome | Position | eGene | 创e Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs10486340 | chr7 | 19244272 | MAP4K1 | 11184 | 0.02 | trans | ||
| rs10253642 | chr7 | 19250373 | MAP4K1 | 11184 | 0.05 | trans | ||
| rs6461405 | chr7 | 19255956 | MAP4K1 | 11184 | 0.02 | trans | ||
| rs10994209 | chr10 | 61877705 | MAP4K1 | 11184 | 0.15 | trans | ||
| rs9636202 | chr19 | 18449237 | MAP4K1 | 11184 | 0.04 | trans | ||
| rs12628787 | chr22 | 29495372 | MAP4K1 | 11184 | 0.14 | trans |
Section II. Transcriptome annotation
创eral gene expression (GTEx)
创e expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
创e expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| BLNK | BASH | BLNK-S | LY57 | MGC111051 | SLP-65 | SLP65 | B-cell linker | - | HPRD,BioGRID | 11514608 |
| CRK | CRKII | v-crk sarcoma virus CT10 oncogene homolog (avian) | HPK1, a Ste-20 homologous serine/threonine kinase phosphorylates Crk, an adaptor protein. | BIND | 9891069 |
| CRK | CRKII | v-crk sarcoma virus CT10 oncogene homolog (avian) | - | HPRD | 9891069|11432831 |
| CRK | CRKII | v-crk sarcoma virus CT10 oncogene homolog (avian) | Affinity Capture-Western Reconstituted Complex |
BioGRID | 9788432|9891069 |
| CRKL | - | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | HPK1, a Ste-20 homologous serine/threonine kinase phosphorylates CrkL, a Crk-like adaptor protein | BIND | 9891069 |
| CRKL | - | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | - | HPRD,BioGRID | 9891069|11279207 |
| DBNL | ABP1 | HIP-55 | SH3P7 | drebrin-like | - | HPRD,BioGRID | 10567356 |
| EGFR | ERBB | ERBB1 | HER1 | PIG61 | mENA | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | - | HPRD,BioGRID | 9346925 |
| GRAP2 | GADS | GRAP-2 | GRB2L | GRBLG | GRID | GRPL | GrbX | Grf40 | Mona | P38 | GRB2-related adaptor protein 2 | Grap2, a hematopoietic, Grb2-related adaptor protein interacts with HPK1, a Ste20-related serine/threonine kinase | BIND | 11313918 |
| GRAP2 | GADS | GRAP-2 | GRB2L | GRBLG | GRID | GRPL | GrbX | Grf40 | Mona | P38 | GRB2-related adaptor protein 2 | - | HPRD,BioGRID | 11313918 |
| GRB2 | ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084 | growth factor receptor-bound protein 2 | - | HPRD,BioGRID | 9346925|9788432 |9891069 |
| GRB2 | ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084 | growth factor receptor-bound protein 2 | HPK1, a Ste-20 homologous serine/threonine kinase interacts with Grb2, an adaptor protein. | BIND | 9891069 |
| HCLS1 | CTTNL | HS1 | hematopoietic cell-specific Lyn substrate 1 | - | HPRD,BioGRID | 10233887 |
| LCP2 | SLP-76 | SLP76 | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) | - | HPRD | 11487585 |
| MAP3K11 | MGC17114 | MLK-3 | MLK3 | PTK1 | SPRK | mitogen-activated protein kinase kinase kinase 11 | - | HPRD,BioGRID | 11053428 |
| MAP3K7 | TAK1 | TGF1a | mitogen-activated protein kinase kinase kinase 7 | - | HPRD,BioGRID | 10224067 |
| NCK1 | MGC12668 | NCK | NCKalpha | NCK adaptor protein 1 | Reconstituted Complex Two-hybrid |
BioGRID | 9346925|9891069 |
| SHC1 | FLJ26504 | SHC | SHCA | SHC (Src homology 2 domain containing) transforming protein 1 | - | HPRD | 9346925 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG MAPK SIGNALING PATHWAY | 267 | 205 | All SZGR 2.0 genes in this pathway |
| BIOCARTA MAPK PATHWAY | 87 | 68 | All SZGR 2.0 genes in this pathway |
| BIOCARTA MET PATHWAY | 37 | 30 | All SZGR 2.0 genes in this pathway |
| SIG IL4RECEPTOR IN B LYPHOCYTES | 27 | 23 | All SZGR 2.0 genes in this pathway |
| SIG BCR SIGNALING PATHWAY | 46 | 38 | All SZGR 2.0 genes in this pathway |
| PID BCR 5PATHWAY | 65 | 50 | All SZGR 2.0 genes in this pathway |
| PID TCR PATHWAY | 66 | 51 | All SZGR 2.0 genes in this pathway |
| PID TCR JNK PATHWAY | 14 | 11 | All SZGR 2.0 genes in this pathway |
| PID KIT PATHWAY | 52 | 40 | All SZGR 2.0 genes in this pathway |
| HOLLMANN APOPTOSIS VIA CD40 UP | 201 | 125 | All SZGR 2.0 genes in this pathway |
| ZHONG RESPONSE TO AZACITIDINE AND TSA UP | 183 | 119 | All SZGR 2.0 genes in this pathway |
| GARY CD5 TARGETS UP | 473 | 314 | All SZGR 2.0 genes in this pathway |
| TAKEDA TARGETS OF NUP98 HOXA9 FUSION 16D UP | 175 | 108 | All SZGR 2.0 genes in this pathway |
| MULLIGHAN NPM1 MUTATED SIGNATURE 1 DN | 126 | 86 | All SZGR 2.0 genes in this pathway |
| MULLIGHAN NPM1 MUTATED SIGNATURE 2 DN | 77 | 46 | All SZGR 2.0 genes in this pathway |
| MULLIGHAN NPM1 SIGNATURE 3 DN | 162 | 116 | All SZGR 2.0 genes in this pathway |
| ZHOU INFLAMMATORY RESPONSE FIMA DN | 284 | 156 | All SZGR 2.0 genes in this pathway |
| HAHTOLA MYCOSIS FUNGOIDES CD4 DN | 116 | 71 | All SZGR 2.0 genes in this pathway |
| DELYS THYROID CANCER UP | 443 | 294 | All SZGR 2.0 genes in this pathway |
| MATTIOLI MGUS VS PCL | 116 | 62 | All SZGR 2.0 genes in this pathway |
| SCHEIDEREIT IKK INTERACTING PROTEINS | 58 | 45 | All SZGR 2.0 genes in this pathway |
| DIRMEIER LMP1 RESPONSE LATE DN | 32 | 22 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY FOXP3 UNSTIMULATED | 1229 | 713 | All SZGR 2.0 genes in this pathway |
| HELLER HDAC TARGETS DN | 292 | 189 | All SZGR 2.0 genes in this pathway |
| 海勒HDAC目标被甲基化DN | 281 | 179 | All SZGR 2.0 genes in this pathway |
| FINETTI BREAST CANCER KINOME GREEN | 16 | 14 | All SZGR 2.0 genes in this pathway |
| WALLACE PROSTATE CANCER RACE UP | 299 | 167 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER RELAPSE IN BONE DN | 315 | 197 | All SZGR 2.0 genes in this pathway |
| 乳腺癌萧述三腔的DN | 564 | 326 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER NORMAL LIKE UP | 476 | 285 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER SURVIVAL UP | 185 | 112 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| RUTELLA RESPONSE TO CSF2RB AND IL4 DN | 315 | 201 | All SZGR 2.0 genes in this pathway |
| RUTELLA RESPONSE TO HGF DN | 235 | 144 | All SZGR 2.0 genes in this pathway |
| RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN | 245 | 150 | All SZGR 2.0 genes in this pathway |
| AGUIRRE PANCREATIC CANCER COPY NUMBER UP | 298 | 174 | All SZGR 2.0 genes in this pathway |
| LEE DIFFERENTIATING T LYMPHOCYTE | 200 | 115 | All SZGR 2.0 genes in this pathway |
| ZHAN V1 LATE DIFFERENTIATION GENES DN | 15 | 13 | All SZGR 2.0 genes in this pathway |
| POOLA INVASIVE BREAST CANCER UP | 288 | 168 | All SZGR 2.0 genes in this pathway |
| CAIRO LIVER DEVELOPMENT UP | 166 | 105 | All SZGR 2.0 genes in this pathway |
| WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP | 397 | 206 | All SZGR 2.0 genes in this pathway |
| LIU IL13 MEMORY MODEL UP | 17 | 12 | All SZGR 2.0 genes in this pathway |