Gene Page:AKAP11

Summary?
GeneID 11215
Symbol AKAP11
Synonyms AKAP-11|AKAP220|PPP1R44|PRKA11
Description A-kinase anchoring protein 11
Reference MIM:604696|HGNC:HGNC:369|Ensembl:ENSG00000023516|HPRD:05261|Vega:OTTHUMG00000016805
Gene type protein-coding
Map location 13q14.11
Pascal p-value 0.01
eGene Anterior cingulate cortex BA24
Cerebellar Hemisphere
Cerebellum
Cortex
Frontal Cortex BA9
Hippocampus
Nucleus accumbens basal ganglia
元

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs9590679 13 42814100 AKAP11 ENSG00000023516.7 2.075E-6 0 -32189 gtex_brain_ba24
rs9315901 13 42817276 AKAP11 ENSG00000023516.7 5.844E-7 0 -29013 gtex_brain_ba24
rs201384113 13 42822568 AKAP11 ENSG00000023516.7 8.223E-8 0 -23721 gtex_brain_ba24
rs2044732 13 42833400 AKAP11 ENSG00000023516.7 8.849E-7 0 -12889 gtex_brain_ba24
rs10492434 13 42838864 AKAP11 ENSG00000023516.7 2.245E-8 0 -7425 gtex_brain_ba24
rs875008 13 42842698 AKAP11 ENSG00000023516.7 2.556E-8 0 -3591 gtex_brain_ba24
rs78738581 13 42843630 AKAP11 ENSG00000023516.7 2.025E-7 0 -2659 gtex_brain_ba24
rs2122242 13 42848853 AKAP11 ENSG00000023516.7 2.182E-7 0 2564 gtex_brain_ba24
rs9590683 13 42850849 AKAP11 ENSG00000023516.7 2.2E-7 0 4560 gtex_brain_ba24
rs146061909 13 42861622 AKAP11 ENSG00000023516.7 3.589E-8 0 15333 gtex_brain_ba24
rs400288 13 42861772 AKAP11 ENSG00000023516.7 3.564E-8 0 15483 gtex_brain_ba24
rs17521426 13 42868208 AKAP11 ENSG00000023516.7 2.209E-7 0 21919 gtex_brain_ba24
rs1964482 13 42868708 AKAP11 ENSG00000023516.7 1.923E-7 0 22419 gtex_brain_ba24
rs9594724 13 42869119 AKAP11 ENSG00000023516.7 2.209E-7 0 22830 gtex_brain_ba24
rs9594726 13 42894409 AKAP11 ENSG00000023516.7 3.263E-7 0 48120 gtex_brain_ba24
rs9590686 13 42903018 AKAP11 ENSG00000023516.7 2.209E-7 0 56729 gtex_brain_ba24
rs9594727 13 42906121 AKAP11 ENSG00000023516.7 2.227E-7 0 59832 gtex_brain_ba24
rs17521870 13 42907942 AKAP11 ENSG00000023516.7 2.209E-7 0 61653 gtex_brain_ba24
rs9594729 13 42911922 AKAP11 ENSG00000023516.7 6.983E-8 0 65633 gtex_brain_ba24
rs9594730 13 42911923 AKAP11 ENSG00000023516.7 6.983E-8 0 65634 gtex_brain_ba24
rs9594731 13 42911955 AKAP11 ENSG00000023516.7 2.209E-7 0 65666 gtex_brain_ba24
rs9594732 13 42912853 AKAP11 ENSG00000023516.7 2.213E-7 0 66564 gtex_brain_ba24
rs9594733 13 42925732 AKAP11 ENSG00000023516.7 3.318E-7 0 79443 gtex_brain_ba24

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13- 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0008157 protein phosphatase 1 binding TAS 10209101
GO:0051018 protein kinase A binding TAS 10209101
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007243 protein kinase cascade TAS 10209101
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005813 centrosome IEA -
GO:0005737 cytoplasm IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
SOTIRIOU BREAST CANCER GRADE 1 VS 3 DN 52 34 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485 334 All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584 356 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893 528 All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP 424 268 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER ACOX1 DN 65 39 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546 351 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER E2F1 DN 64 42 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434 302 All SZGR 2.0 genes in this pathway
RIGGINS TAMOXIFEN RESISTANCE DN 220 147 All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN DN 249 165 All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682 440 All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548 370 All SZGR 2.0 genes in this pathway
IVANOVSKA MIR106B TARGETS 90 56 All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 AND SATB1 DN 180 116 All SZGR 2.0 genes in this pathway
KRIEG KDM3A TARGETS NOT HYPOXIA 208 107 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-1/206 3571 3577 m8 hsa-miR-1 UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZ UGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613 AGGAAUGUUCCUUCUUUGCC
miR-130/301 3883 3889 1A hsa-miR-130abrain CAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301 CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrain CAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3p UAGUGCAAUAUUGCUUAUAGGGUUU
miR-15/16/195/424/497 323 330 1A,m8 hsa-miR-15abrain UAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrain UAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZ UAGCAGCACAGAAAUAUUGGC
hsa-miR-424 CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497 CAGCAGCACACUGUGGUUUGU
miR-205 255 261 1A hsa-miR-205 UCCUUCAUUCCACCGGAGUCUG
miR-217 839 845 1A hsa-miR-217 UACUGCAUCAGGAACUGAUUGGAU