Gene Page:KLF12

Summary?
GeneID 11278
Symbol KLF12
Synonyms AP-2rep|AP2REP|HSPC122
Description Kruppel-like factor 12
Reference MIM:607531|HGNC:HGNC:6346|Ensembl:ENSG00000118922|HPRD:06336|Vega:OTTHUMG00000017078
Gene type protein-coding
Map location 13q22
Pascal p-value 0.002
Sherlock p-value 0.234
这样假定值 0.01
Fetal beta 1.001
DMG 1 (# studies)
eGene Myers' cis & trans
Support CompositeSet

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
DNM:Xu_2012 Whole Exome Sequencing analysis 新创的突变4 b基因被确定y exome sequencing of 795 samples in this study

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
KLF12 chr13 74289537 G C NM_007249 p.332S>C missense Schizophrenia DNM:Xu_2012

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg10959786 13 74708124 KLF12 2.7E-8 -0.01 8.55E-6 DMG:Jaffe_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs1561519 chr2 35823020 KLF12 11278 0.01 trans
rs1371418 chr2 35830333 KLF12 11278 0.03 trans
rs7570146 chr2 35844751 KLF12 11278 0.01 trans
rs1439689 chr2 35851217 KLF12 11278 0.14 trans
rs1439691 chr2 35851281 KLF12 11278 0.01 trans
rs9355872 chr6 161534332 KLF12 11278 0.17 trans
rs9548306 chr13 38876011 KLF12 11278 0.17 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0003700 transcription factor activity IDA 16615998
GO:0003714 transcription corepressor activity TAS 10704285
GO:0008270 zinc ion binding IEA -
GO:0046872 metal ion binding IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 16615998
GO:0006350 transcription IEA -
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005622 intracellular IEA -
GO:0005634 nucleus IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PARENT MTOR SIGNALING UP 567 375 All SZGR 2.0 genes in this pathway
ZHONG RESPONSE TO AZACITIDINE AND TSA UP 183 119 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE DN 384 220 All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE DN 244 147 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP 544 308 All SZGR 2.0 genes in this pathway
ODONNELL METASTASIS UP 82 58 All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS C UP 170 114 All SZGR 2.0 genes in this pathway
KAN RESPONSE TO ARSENIC TRIOXIDE 123 80 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE UP 134 93 All SZGR 2.0 genes in this pathway
AMUNDSON RESPONSE TO ARSENITE 217 143 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN 428 306 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681 420 All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE UP 578 341 All SZGR 2.0 genes in this pathway
MELLMAN TUT1 TARGETS DN 47 29 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898 516 All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 DN 448 282 All SZGR 2.0 genes in this pathway
PECE MAMMARY STEM CELL DN 146 88 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-101 9108 9114 1A hsa-miR-101 UACAGUACUGUGAUAACUGAAG
miR-124.1 4018 4024 1A hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-137 1565 1572 1A,m8 hsa-miR-137 UAUUGCUUAAGAAUACGCGUAG
hsa-miR-137 UAUUGCUUAAGAAUACGCGUAG
hsa-miR-137 UAUUGCUUAAGAAUACGCGUAG
miR-138 8339 8345 1A hsa-miR-138brain AGCUGGUGUUGUGAAUC
hsa-miR-138brain AGCUGGUGUUGUGAAUC
hsa-miR-138brain AGCUGGUGUUGUGAAUC
miR-141/200a 9220 9226 1A hsa-miR-141 UAACACUGUCUGGUAAAGAUGG
hsa-miR-200a UAACACUGUCUGGUAACGAUGU
miR-144 9108 9114 1A hsa-miR-144 UACAGUAUAGAUGAUGUACUAG
miR-151 8463 8470 1A,m8 hsa-miR-151brain ACUAGACUGAAGCUCCUUGAGG
miR-17-5p/20/93.mr/106/519.d 3468 3474 m8 hsa-miR-17-5p CAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519d CAAAGUGCCUCCCUUUAGAGUGU
hsa-miR-17-5p CAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519d CAAAGUGCCUCCCUUUAGAGUGU
miR-188 1077 1083 m8 hsa-miR-188 CAUCCCUUGCAUGGUGGAGGGU
miR-194 469 475 m8 hsa-miR-194 UGUAACAGCAACUCCAUGUGGA
miR-199 901 907 m8 hsa-miR-199a CCCAGUGUUCAGACUACCUGUUC
hsa-miR-199b CCCAGUGUUUAGACUAUCUGUUC
miR-200bc/429 3740 3746 m8 hsa-miR-200b UAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
hsa-miR-200b UAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
miR-203.1 2886 2892 1A hsa-miR-203 UGAAAUGUUUAGGACCACUAG
miR-204/211 1076 1082 m8 hsa-miR-204brain UUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211 UUCCCUUUGUCAUCCUUCGCCU
miR-205 9358 9364 m8 hsa-miR-205 UCCUUCAUUCCACCGGAGUCUG
hsa-miR-205 UCCUUCAUUCCACCGGAGUCUG
miR-217 3737 3744 1A,m8 hsa-miR-217 UACUGCAUCAGGAACUGAUUGGAU
miR-218 2922 2928 m8 hsa-miR-218brain UUGUGCUUGAUCUAACCAUGU
hsa-miR-218brain UUGUGCUUGAUCUAACCAUGU
miR-224 8441 8447 1A hsa-miR-224 CAAGUCACUAGUGGUUCCGUUUA
miR-25/32/92/363/367 1745 1751 1A hsa-miR-25brain CAUUGCACUUGUCUCGGUCUGA
hsa-miR-32 UAUUGCACAUUACUAAGUUGC
hsa-miR-92 UAUUGCACUUGUCCCGGCCUG
hsa-miR-367 AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZ UAUUGCACUCGUCCCGGCCUC
hsa-miR-25brain CAUUGCACUUGUCUCGGUCUGA
hsa-miR-32 UAUUGCACAUUACUAAGUUGC
hsa-miR-92 UAUUGCACUUGUCCCGGCCUG
hsa-miR-367 AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZ UAUUGCACUCGUCCCGGCCUC
miR-27 9301 9307 1A hsa-miR-27abrain UUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrain UUCACAGUGGCUAAGUUCUGC
miR-29 1339 1346 1A,m8 hsa-miR-29aSZ UAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZ UAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZ UAGCACCAUUUGAAAUCGGU
miR-329 8481 8487 m8 hsa-miR-329brain AACACACCUGGUUAACCUCUUU
miR-33 8294 8300 1A hsa-miR-33 GUGCAUUGUAGUUGCAUUG
hsa-miR-33b GUGCAUUGCUGUUGCAUUGCA
miR-34/449 4249 4255 m8 hsa-miR-34abrain UGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34c AGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449 UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449b AGGCAGUGUAUUGUUAGCUGGC
miR-342 8227 8233 1A hsa-miR-342brain UCUCACACAGAAAUCGCACCCGUC
miR-34b 4250 4256 m8 hsa-miR-34b UAGGCAGUGUCAUUAGCUGAUUG
miR-370 57 63 m8 hsa-miR-370brain GCCUGCUGGGGUGGAACCUGG
hsa-miR-370brain GCCUGCUGGGGUGGAACCUGG
miR-376 9289 9295 1A hsa-miR-376a AUCAUAGAGGAAAAUCCACGU
hsa-miR-376b AUCAUAGAGGAAAAUCCAUGUU
miR-376c 8180 8186 m8 hsa-miR-376c AACAUAGAGGAAAUUCCACG
miR-381 9053 9059 m8 hsa-miR-381 UAUACAAGGGCAAGCUCUCUGU
hsa-miR-381 UAUACAAGGGCAAGCUCUCUGU
miR-409-5p 163 169 m8 hsa-miR-409-5p AGGUUACCCGAGCAACUUUGCA
miR-410 8989 8995 1A hsa-miR-410 AAUAUAACACAGAUGGCCUGU
miR-539 7353 7360 1A,m8 hsa-miR-539 GGAGAAAUUAUCCUUGGUGUGU
miR-542-3p 825 831 m8 hsa-miR-542-3p UGUGACAGAUUGAUAACUGAAA
miR-7 4218 4225 1A,m8 hsa-miR-7SZ UGGAAGACUAGUGAUUUUGUUG
miR-9 3776 3782 m8 hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA
miR-93.hd/291-3p/294/295/302/372/373/520 3467 3473 m8 hsa-miR-93brain AAAGUGCUGUUCGUGCAGGUAG
hsa-miR-302a UAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302b UAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302c UAAGUGCUUCCAUGUUUCAGUGG
hsa-miR-302d UAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372 AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373 GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520e AAAGUGCUUCCUUUUUGAGGG
hsa-miR-520a AAAGUGCUUCCCUUUGGACUGU
hsa-miR-520b AAAGUGCUUCCUUUUAGAGGG
hsa-miR-520c AAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520d AAAGUGCUUCUCUUUGGUGGGUU