Gene Page:CHRM1

Summary?
GeneID 1128
Symbol CHRM1
Synonyms HM1|M1|M1R
Description cholinergic receptor muscarinic 1
Reference MIM:118510|HGNC:HGNC:1950|Ensembl:ENSG00000168539|HPRD:00338|Vega:OTTHUMG00000167765
Gene type protein-coding
Map location 11q13
Pascal p-value 0.214
Sherlock p-value 6.636E-5
Fetal beta -2.396
Support GPCR SIGNALLING

Gene in Data Sources
Gene set name Method of gene set Description Info
ADT:Sun_2012 Systematic Investigation of Antipsychotic Drugs and Their Targets A total of 382 drug-target associations involving 43 antipsychotic drugs and 49 target genes.
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 2

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RGS16 0.94 0.45
SUSD2 0.93 -0.06
EPN3 0.92 0.32
GRID2IP 0.91 0.37
PTPN3 0.90 0.34
FAM19A4 0.90 0.19
TTC39A 0.89 0.37
CARD11 0.89 0.28
GNG13 0.88 0.17
RGS3 0.88 0.49
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
WDR86 -0.21 -0.01
EMID1 -0.20 -0.07
SLC26A4 -0.17 0.11
ETV4 -0.16 -0.19
MEIS3P2 -0.16 0.38
OAF -0.16 -0.34
RGS20 -0.16 -0.29
NPAS1 -0.16 0.06
TMOD1 -0.16 0.14
RLBP1 -0.16 -0.34

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0004872 receptor activity IEA -
GO:0004981 muscarinic acetylcholine receptor activity TAS 9614217
GO:0004435 phosphoinositide phospholipase C activity TAS 9614217
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0007399 nervous system development TAS neurite (GO term level: 5) 2739737
GO:0007205 activation of protein kinase C activity TAS 9603968
GO:0006464 蛋白质改性过程 TAS 1411529
GO:0007207 muscarinic acetylcholine receptor, phospholipase C activating pathway TAS 8139539
GO:0007213 acetylcholine receptor signaling, muscarinic pathway TAS 8139539
GO:0007165 signal transduction TAS 3443095|9614217
GO:0008284 positive regulation of cell proliferation TAS 2739737
GO:0040012 regulation of locomotion IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0045211 postsynaptic membrane IEA Synap, Neurotransmitter (GO term level: 5) -
GO:0045202 synapse IEA neuron, Synap, Neurotransmitter, Glial (GO term level: 2) -
GO:0005624 membrane fraction TAS 7925360
GO:0005886 plasma membrane TAS 7925360
GO:0005887 integral to plasma membrane TAS 8508928
GO:0030054 cell junction IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CALCIUM SIGNALING PATHWAY 178 134 All SZGR 2.0 genes in this pathway
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272 195 All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON 216 144 All SZGR 2.0 genes in this pathway
BIOCARTA第一途径 33 24 All SZGR 2.0 genes in this pathway
BIOCARTA AGR PATHWAY 36 31 All SZGR 2.0 genes in this pathway
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 205 136 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305 177 All SZGR 2.0 genes in this pathway
REACTOME AMINE LIGAND BINDING RECEPTORS 38 33 All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Q SIGNALLING EVENTS 184 116 All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805 368 All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408 246 All SZGR 2.0 genes in this pathway
RODRIGUES NTN1 TARGETS DN 158 102 All SZGR 2.0 genes in this pathway
TANAKA METHYLATED IN ESOPHAGEAL CARCINOMA 103 58 All SZGR 2.0 genes in this pathway
MCCLUNG DELTA FOSB TARGETS 8WK 47 38 All SZGR 2.0 genes in this pathway
HUANG DASATINIB RESISTANCE DN 69 44 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
MIKKELSEN ES LCP WITH H3K27ME3 14 8 All SZGR 2.0 genes in this pathway
STAMBOLSKY TARGETS OF MUTATED TP53 DN 50 24 All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1 467 251 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-103/107 845 851 m8 hsa-miR-103brain AGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brain AGCAGCAUUGUACAGGGCUAUCA
miR-27 1010 1016 1A hsa-miR-27abrain UUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrain UUCACAGUGGCUAAGUUCUGC
miR-491 867 873 1A hsa-miR-491brain AGUGGGGAACCCUUCCAUGAGGA