Gene Page:LYST
概括?
| 基因 | 1130 |
| 象征 | LYST |
| Synonyms | CHS|CHS1 |
| Description | 溶酶体贩运调节剂 |
| Reference | MIM：606897|HGNC:HGNC:1968|ENSEMBL：ENSG00000143669|HPRD：06060|Vega：Otthumg0000000040527 |
| Gene type | protein-coding |
| Map location | 1q42.1-q42.2 |
| DMG | 1 (# studies) |
数据源中的基因
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
第一节遗传学和表观遗传学注释
Differentially methylated gene
Differentially methylated gene| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg25377475 | 1 | 236030556 | LYST | 2.238E-4 | -0.186 | 0.036 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| RBBP4 | 0.87 | 0.84 |
| ODC1 | 0.87 | 0.82 |
| NONO | 0.86 | 0.87 |
| ZNF649 | 0.86 | 0.79 |
| RNF122 | 0.86 | 0.72 |
| RBMX | 0.86 | 0.83 |
| MSH6 | 0.85 | 0.85 |
| GNAI3 | 0.85 | 0.82 |
| ppm1d | 0.85 | 0.80 |
| UNG | 0.85 | 0.70 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| TNFSF12 | -0.58 | -0.63 |
| HLA-F | -0.58 | -0.76 |
| PTH1R | -0.56 | -0.68 |
| C5orf53 | -0.56 | -0.67 |
| SLC9A3R2 | -0.55 | -0.48 |
| SLC16A11 | -0.55 | -0.64 |
| TINAGL1 | -0.55 | -0.71 |
| LHPP | -0.54 | -0.58 |
| AF347015.27 | -0.54 | -0.80 |
| AF347015.31 | -0.54 | -0.79 |
第四节。蛋白质蛋白相互作用注释
| Interactors | Aliases B | Official full name B | Experimental | 资源 | PubMed ID |
|---|---|---|---|---|---|
| ATN1 | B37 | D12S755E | DRPLA | NOD | atrophin 1 | - | HPRD,BioGRID | 11984006 |
| BRUNOL4 | BRUNOL-4 | CELF4 | bruno-like 4, RNA binding protein (Drosophila) | 两个杂交 | BioGRID | 11984006 |
| CALM1 | CALML2 | CAMI | DD132 | PHKD | calmodulin 1 (phosphorylase kinase, delta) | - | HPRD | 11984006 |
| CENPJ | BM032 | CPAP | LAP | LIP1 | MCPH6 | MGC131581 | MGC131582 | MGC142222 | MGC142224 | centromere protein J | 两个杂交 | BioGRID | 11984006 |
| CNTROB | LIP8 | PP1221 | centrobin, centrosomal BRCA2 interacting protein | - | HPRD,BioGRID | 11984006 |
| CSNK2B | CK2B |CK2N |CSK2B |g5a |MGC138222 |MGC138224 | casein kinase 2, beta polypeptide | - | HPRD,BioGRID | 11984006 |
| DGCR14 | DGCR13 | DGS-H | DGS-I | DGSH | DGSI | ES2 | Es2el | DiGeorge syndrome critical region gene 14 | - | HPRD,BioGRID | 11984006 |
| DNAJC14 | DNAJ | DRIP78 | HDJ3 | LIP6 | DnaJ (Hsp40) homolog, subfamily C, member 14 | - | HPRD,BioGRID | 11984006 |
| EFS | CAS3 | CASS3 | EFS1 | EFS2 | HEFS | SIN | embryonal Fyn-associated substrate | 两个杂交 | BioGRID | 11984006 |
| ESRRA | ERR1 | ERRa | ERRalpha | ESRL1 | NR3B1 | estrogen-related receptor alpha | - | HPRD,BioGRID | 11984006 |
| HGS | HRS | ZFYVE8 | hepatocyte growth factor-regulated tyrosine kinase substrate | - | HPRD,BioGRID | 11984006 |
| HNRNPM | DKFZp547H118 | HNRNPM4 | HNRPM | HNRPM4 | HTGR1 | NAGR1 | heterogeneous nuclear ribonucleoprotein M | - | HPRD,BioGRID | 11984006 |
| KPNB1 | IMB1 | IPOB | Impnb | MGC2155 | MGC2156 | MGC2157 | NTF97 | karyopherin (importin) beta 1 | - | HPRD,BioGRID | 11984006 |
| MED12 | CAGH45 | HOPA | KIAA0192 | OPA1 | TNRC11 | TRAP230 | mediator complex subunit 12 | - | HPRD,BioGRID | 11984006 |
| MRPL17 | L17mt | LIP2 | MRP-L17 | MRP-L26 | RPL17L | RPML26 | mitochondrial ribosomal protein L17 | - | HPRD,BioGRID | 11984006 |
| MRPS31 | IMOGN38 | MRP-S31 | S31mt | mitochondrial ribosomal protein S31 | 两个杂交 | BioGRID | 11984006 |
| NCDN | KIAA0607 | neurochondrin | - | HPRD,BioGRID | 11984006 |
| PCBP4 | LIP4 | MCG10 | poly(rC) binding protein 4 | 两个杂交 | BioGRID | 11984006 |
| tnni3 | CMD2A | CMH7 | MGC116817 | TNNC1 | cTnI | troponin I type 3 (cardiac) | 两个杂交 | BioGRID | 11984006 |
| VTA1 | C6orf55 | DRG-1 | DRG1 | FLJ27228 | HSPC228 | LIP5 | My012 | SBP1 | Vps20-associated 1 homolog (S. cerevisiae) | 两个杂交 | BioGRID | 11984006 |
| YWHAB | GW128 | HS1 | KCIP-1 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide | - | HPRD,BioGRID | 11984006 |
| YWHAQ | 14-3-3 |1c5 |HS1 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide | - | HPRD,BioGRID | 11984006 |
| YWHAZ | KCIP-1 | MGC111427 | MGC126532 | MGC138156 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | Reconstituted Complex | BioGRID | 11984006 |
| ZNF521 | DKFZP564D0764 |EHZF |EVI3 |MGC142182 |MGC142208 | zinc finger protein 521 | 两个杂交 | BioGRID | 11984006 |
V.途径注释
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| LIU PROSTATE CANCER DN | 481 | 290 | 该途径中的所有SZGR 2.0基因 |
| OSMAN BLADDER CANCER UP | 404 | 246 | 该途径中的所有SZGR 2.0基因 |
| MULLIGHAN MLL SIGNATURE 1 UP | 380 | 236 | 该途径中的所有SZGR 2.0基因 |
| ENK UV RESPONSE KERATINOCYTE DN | 485 | 334 | 该途径中的所有SZGR 2.0基因 |
| VANHARANTA UTERINE FIBROID WITH 7Q DELETION DN | 36 | 23 | 该途径中的所有SZGR 2.0基因 |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | 该途径中的所有SZGR 2.0基因 |
| XU HGF TARGETS REPRESSED BY AKT1 DN | 95 | 58 | 该途径中的所有SZGR 2.0基因 |
| XU AKT1 TARGETS 6HR | 27 | 18 | 该途径中的所有SZGR 2.0基因 |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN | 584 | 395 | 该途径中的所有SZGR 2.0基因 |
| NUYTTEN EZH2 TARGETS UP | 1037 | 673 | 该途径中的所有SZGR 2.0基因 |
| BUYTAERT PHOTODYNAMIC THERAPY STRESS UP | 811 | 508 | 该途径中的所有SZGR 2.0基因 |
| BYSTROEM CORRELATED WITH IL5 DN | 64 | 47 | 该途径中的所有SZGR 2.0基因 |
| MATSUDA NATURAL KILLER DIFFERENTIATION | 475 | 313 | 该途径中的所有SZGR 2.0基因 |
| YAGI AML SURVIVAL | 129 | 87 | 该途径中的所有SZGR 2.0基因 |
| IVANOVA HEMATOPOIESIS LATE PROGENITOR | 544 | 307 | 该途径中的所有SZGR 2.0基因 |
| CUI TCF21 TARGETS 2 DN | 830 | 547 | 该途径中的所有SZGR 2.0基因 |
| CHANG IMMORTALIZED BY HPV31 DN | 65 | 45 | 该途径中的所有SZGR 2.0基因 |
| BLALOCK ALZHEIMERS DISEASE UP | 1691年 | 1088 | 该途径中的所有SZGR 2.0基因 |
| KRIGE RESPONSE TO TOSEDOSTAT 6HR DN | 911 | 527 | 该途径中的所有SZGR 2.0基因 |
| KRIGE RESPONSE TO TOSEDOSTAT 24HR DN | 1011 | 592 | 该途径中的所有SZGR 2.0基因 |
| Gavin Foxp3目标集群P7 | 90 | 52 | 该途径中的所有SZGR 2.0基因 |
| ACEVEDO LIVER CANCER WITH H3K27ME3 DN | 228 | 114 | 该途径中的所有SZGR 2.0基因 |
| BRUECKNER TARGETS OF MIRLET7A3 UP | 111 | 69 | 该途径中的所有SZGR 2.0基因 |
| PARK APL PATHOGENESIS DN | 50 | 35 | 该途径中的所有SZGR 2.0基因 |
| Yoshimura MAPK8目标DN | 366 | 257 | 该途径中的所有SZGR 2.0基因 |
| LEE DOUBLE POLAR THYMOCYTE | 27 | 17 | 该途径中的所有SZGR 2.0基因 |
| CAIRO LIVER DEVELOPMENT DN | 222 | 141 | 该途径中的所有SZGR 2.0基因 |
| Browne HCMV感染4小时DN | 254 | 158 | 该途径中的所有SZGR 2.0基因 |
| Dutertre雌二醇反应24小时DN | 505 | 328 | 该途径中的所有SZGR 2.0基因 |
| FEVR CTNNB1 TARGETS UP | 682 | 433 | 该途径中的所有SZGR 2.0基因 |
| TORCHIA TARGETS OF EWSR1 FLI1 FUSION UP | 271 | 165 | 该途径中的所有SZGR 2.0基因 |
| PEDERSEN METASTASIS BY ERBB2 ISOFORM 7 | 403 | 240 | 该途径中的所有SZGR 2.0基因 |
| 他的目标611 ERBB2的清洁技术基金对碘氧基苯甲醚 | 76 | 45 | 该途径中的所有SZGR 2.0基因 |
| ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF | 516 | 308 | 该途径中的所有SZGR 2.0基因 |