Gene Page:CHRM3
Summary?
| GeneID | 1131 |
| Symbol | CHRM3 |
| Synonyms | EGBRS|HM3|PBS |
| Description | cholinergic receptor muscarinic 3 |
| Reference | MIM:118494|HGNC:HGNC:1952|Ensembl:ENSG00000133019|HPRD:00329| |
| Gene type | 蛋白质-coding |
| Map location | 1q43 |
| Sherlock p-value | 0.905 |
| Fetal beta | -1.67 |
| DMG | 2 (# studies) |
| eGene | 元 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| ADT:Sun_2012 | Systematic Investigation of Antipsychotic Drugs and Their Targets | A total of 382 drug-target associations involving 43 antipsychotic drugs and 49 target genes. | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 2 |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 2 |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias | Click to show details |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 2 | |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0018 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Differentially methylated gene| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg08258494 | 1 | 239987344 | CHRM3 | 5.793E-4 | 0.471 | 0.049 | DMG:Wockner_2014 |
| cg19238058 | 1 | 239551177 | CHRM3 | 7.8E-9 | -0.015 | 3.77E-6 | DMG:Jaffe_2016 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MPP2 | 0.79 | 0.80 |
| C9orf125 | 0.75 | 0.77 |
| TNFAIP1 | 0.75 | 0.74 |
| PNMAL1 | 0.75 | 0.78 |
| KLHDC5 | 0.74 | 0.77 |
| SV2A | 0.74 | 0.80 |
| SEMA4F | 0.73 | 0.73 |
| PIP5K1C | 0.73 | 0.79 |
| FAM53C | 0.73 | 0.78 |
| PLEKHB2 | 0.72 | 0.77 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AL139819.3 | -0.50 | -0.54 |
| AF347015.21 | -0.46 | -0.45 |
| AP002478.3 | -0.45 | -0.48 |
| MT-CO2 | -0.45 | -0.44 |
| NOSTRIN | -0.45 | -0.45 |
| AF347015.26 | -0.44 | -0.38 |
| AF347015.18 | -0.44 | -0.45 |
| MT-CYB | -0.44 | -0.43 |
| AF347015.8 | -0.44 | -0.44 |
| GNG11 | -0.44 | -0.45 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004872 | receptor activity | TAS | 10940357 | |
| GO:0004981 | muscarinic acetylcholine receptor activity | TAS | 9547368 | |
| GO:0004435 | phosphoinositide phospholipase C activity | TAS | 1905013 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0007399 | nervous system development | TAS | neurite (GO term level: 5) | 2739737 |
| GO:0007186 | G-protein coupled receptor protein signaling pathway | TAS | 9603968 | |
| GO:0006464 | 蛋白质modification process | TAS | 10051746 | |
| GO:0007165 | signal transduction | TAS | 10940357 | |
| GO:0008283 | cell proliferation | TAS | 8063729 | |
| GO:0007586 | digestion | IEA | - | |
| GO:0045987 | positive regulation of smooth muscle contraction | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0045211 | postsynaptic membrane | IEA | Synap, Neurotransmitter (GO term level: 5) | - |
| GO:0045202 | synapse | IEA | neuron, Synap, Neurotransmitter, Glial (GO term level: 2) | - |
| GO:0005886 | plasma membrane | TAS | 9547368 | |
| GO:0005887 | integral to plasma membrane | TAS | 3443095 | |
| GO:0016323 | basolateral plasma membrane | IEA | - | |
| GO:0030054 | cell junction | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG CALCIUM SIGNALING PATHWAY | 178 | 134 | 艾尔l SZGR 2.0 genes in this pathway |
| KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION | 272 | 195 | 艾尔l SZGR 2.0 genes in this pathway |
| KEGG REGULATION OF ACTIN CYTOSKELETON | 216 | 144 | 艾尔l SZGR 2.0 genes in this pathway |
| REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK | 205 | 136 | 艾尔l SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY GPCR | 920 | 449 | 艾尔l SZGR 2.0 genes in this pathway |
| REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | 305 | 177 | 艾尔l SZGR 2.0 genes in this pathway |
| REACTOME INTEGRATION OF ENERGY METABOLISM | 120 | 84 | 艾尔l SZGR 2.0 genes in this pathway |
| REACTOME AMINE LIGAND BINDING RECEPTORS | 38 | 33 | 艾尔l SZGR 2.0 genes in this pathway |
| REACTOME G ALPHA Q SIGNALLING EVENTS | 184 | 116 | 艾尔l SZGR 2.0 genes in this pathway |
| REACTOME REGULATION OF INSULIN SECRETION | 93 | 65 | 艾尔l SZGR 2.0 genes in this pathway |
| REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | 11 | 9 | 艾尔l SZGR 2.0 genes in this pathway |
| REACTOME GPCR DOWNSTREAM SIGNALING | 805 | 368 | 艾尔l SZGR 2.0 genes in this pathway |
| REACTOME GPCR LIGAND BINDING | 408 | 246 | 艾尔l SZGR 2.0 genes in this pathway |
| SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 UP | 408 | 247 | 艾尔l SZGR 2.0 genes in this pathway |
| VECCHI GASTRIC CANCER EARLY DN | 367 | 220 | 艾尔l SZGR 2.0 genes in this pathway |
| NUYTTEN NIPP1 TARGETS DN | 848 | 527 | 艾尔l SZGR 2.0 genes in this pathway |
| LANDEMAINE LUNG METASTASIS | 21 | 12 | 艾尔l SZGR 2.0 genes in this pathway |
| ACEVEDO和H3K27ME3肝癌 | 295 | 149 | 艾尔l SZGR 2.0 genes in this pathway |
| ACEVEDO METHYLATED IN LIVER CANCER DN | 940 | 425 | 艾尔l SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER RELAPSE IN BONE DN | 315 | 197 | 艾尔l SZGR 2.0 genes in this pathway |
| 乳腺癌萧述三腔的DN | 564 | 326 | 艾尔l SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER BASAL UP | 648 | 398 | 艾尔l SZGR 2.0 genes in this pathway |
| CHANDRAN METASTASIS DN | 306 | 191 | 艾尔l SZGR 2.0 genes in this pathway |
| HOELZEL NF1 TARGETS UP | 139 | 93 | 艾尔l SZGR 2.0 genes in this pathway |
| BHAT ESR1 TARGETS NOT VIA AKT1 DN | 88 | 61 | 艾尔l SZGR 2.0 genes in this pathway |