Gene Page:GABARAP

概括?
基因 11337
Symbol GABARAP
Synonyms ATG8A|GABARAP-a|MM46
Description GABA(A) receptor-associated protein
Reference MIM:605125|HGNC:HGNC:4067|HPRD:05496|
Gene type protein-coding
Map location 17p13.1
Pascal p-value 2.022E-4
Sherlock p-value 0.987
Fetal beta 0.45
eGene Myers' cis & trans

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations 与神经相关关键字的命中：2

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs6516671 chr21 26806125 GABARAP 11337 0.07 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO：0050811 GABA receptor binding 新闻学会 GABA（GO期限：5） 9892355
GO:0005515 protein binding 新闻学会 11096062|11146101
GO:0008017 microtubule binding IEA -
GO:0048487 beta-tubulin binding IDA 9892355
生物过程 GO term Evidence Neuro keywords PubMed ID
GO:0007268 synaptic transmission TAS neuron, Synap, Neurotransmitter (GO term level: 6) 9892355
GO:0000226 microtubule cytoskeleton organization IEA -
GO:0006605 protein targeting TAS 9892355
GO:0015031 protein transport IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0000139 Golgi membrane IEA -
GO:0000421 autophagic vacuole membrane IDA 15169837
GO:0005794 Golgi apparatus IEA -
GO:0005874 microtubule IEA -
GO:0005875 microtubule associated complex IEA -
GO:0005790 smooth endoplasmic reticulum IEA -
GO:0005737 细胞质 IEA -
GO:0005764 lysosome IEA -
GO:0005886 plasma membrane TAS 9892355
GO:0015629 actin cytoskeleton IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ATG3 APG3 |类似APG3 |APG3L |DKFZP564M1178 |FLJ22125 |MGC15201 |PC3-96 ATG3 autophagy related 3 homolog (S. cerevisiae) - HPRD 11825910
ATG4B APG4B | AUTL1 | MGC1353 ATG4自噬相关4同族体B (S. cerevisiae) 两个杂交 BioGRID 16169070
ATG7 APG7-LIKE | APG7L | DKFZp434N0735 | GSA7 ATG7 autophagy related 7 homolog (S. cerevisiae) - HPRD 11890701
GABARAP FLJ25768 | MGC120154 | MGC120155 | MM46 GABA(A) receptor-associated protein - HPRD,BioGRID 11779480|12367594
GABRG2 CAE2 | ECA2 | GEFSP3 γ-氨基丁酸（GABA）受体伽马2 - HPRD,BioGRID 9892355
GPHN geph |GPH |gphryn |KIAA1385 gephyrin - HPRD 10900017
HDAC5 FLJ90614 | HD5 | NY-CO-9 histone deacetylase 5 两个杂交 BioGRID 16169070
NSF SKD2 N-ethylmaleimide-sensitive factor - HPRD 11461150
TFRC CD71 | TFR | TFR1 | TRFR transferrin receptor (p90, CD71) - HPRD,BioGRID 11997026
TUBB3 MC1R | TUBB4 | beta-4 tubulin, beta 3 两个杂交 BioGRID 16169070
ULK1 ATG1 | FLJ38455 | UNC51 | Unc51.1 unc-51-like kinase 1 (C. elegans) - HPRD,BioGRID 11146101


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG REGULATION OF AUTOPHAGY 35 30 该途径中的所有SZGR 2.0基因
BIOCARTA GABA PATHWAY 10 10 该途径中的所有SZGR 2.0基因
GARY CD5 TARGETS UP 473 314 该途径中的所有SZGR 2.0基因
ENK UV RESPONSE KERATINOCYTE UP 530 342 该途径中的所有SZGR 2.0基因
BERENJENO TRANSFORMED BY RHOA DN 394 258 该途径中的所有SZGR 2.0基因
LOPEZ MBD TARGETS 957 597 该途径中的所有SZGR 2.0基因
KOYAMA SEMA3B TARGETS DN 411 249 该途径中的所有SZGR 2.0基因
BENPORATH MYC MAX TARGETS 775 494 该途径中的所有SZGR 2.0基因
BASSO B LYMPHOCYTE NETWORK 143 96 该途径中的所有SZGR 2.0基因
YAGI AML RELAPSE PROGNOSIS 35 24 该途径中的所有SZGR 2.0基因
PENG GLUCOSE DEPRIVATION DN 169 112 该途径中的所有SZGR 2.0基因
HASLINGER B CLL WITH 17P13 DELETION 21 15 该途径中的所有SZGR 2.0基因
YAGI AML SURVIVAL 129 87 该途径中的所有SZGR 2.0基因
MA PITUITARY FETAL VS ADULT DN 19 17 该途径中的所有SZGR 2.0基因
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 该途径中的所有SZGR 2.0基因
ALONSO METASTASIS UP 198 128 该途径中的所有SZGR 2.0基因
DANG BOUND BY MYC 1103 714 该途径中的所有SZGR 2.0基因
KARLSSON TGFB1 TARGETS DN 207 139 该途径中的所有SZGR 2.0基因
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756 494 该途径中的所有SZGR 2.0基因
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682 440 该途径中的所有SZGR 2.0基因
JOHNSTONE PARVB TARGETS 3 UP 430 288 该途径中的所有SZGR 2.0基因
HUANG GATA2 TARGETS UP 149 96 该途径中的所有SZGR 2.0基因
KRIEG KDM3A TARGETS NOT HYPOXIA 208 107 该途径中的所有SZGR 2.0基因
FORTSCHEGGER PHF8 TARGETS DN 784 464 该途径中的所有SZGR 2.0基因
MIZUSHIMA AUTOPHAGOSOME FORMATION 19 15 该途径中的所有SZGR 2.0基因
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 该途径中的所有SZGR 2.0基因
ZWANG EGF INTERVAL DN 214 124 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-140 420 426 m8 hsa-miR-140brain AGUGGUUUUACCCUAUGGUAG
miR-455 402 408 m8 hsa-miR-455 UAUGUGCCUUUGGACUACAUCG
mir-542-3p 262 268 1A hsa-miR-542-3p UGUGACAGAUUGAUAACUGAAA