Gene Page:CHRNA1
Summary?
| GeneID | 1134 |
| Symbol | CHRNA1 |
| Synonyms | ACHRA|ACHRD|CHRNA|CMS1A|CMS1B|CMS2A|FCCMS|SCCMS |
| Description | cholinergic receptor nicotinic alpha 1 subunit |
| Reference | MIM:100690|HGNC:HGNC:1955|Ensembl:ENSG00000138435|HPRD:00007|Vega:OTTHUMG00000132357 |
| Gene type | protein-coding |
| Map location | 2 q31.1 |
| Pascal p-value | 0.1 |
| Fetal beta | 0.025 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias | Click to show details |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 5 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| KCNC2 | 0.75 | 0.75 |
| ANXA6 | 0.73 | 0.77 |
| PTHLH | 0.71 | 0.75 |
| SIAE | 0.71 | 0.73 |
| SSTR3 | 0.70 | 0.77 |
| SNX10 | 0.70 | 0.70 |
| REEP5 | 0.69 | 0.67 |
| RAB37 | 0.69 | 0.74 |
| GPR123 | 0.69 | 0.66 |
| SGPP2 | 0.69 | 0.69 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| TUBB2B | -0.43 | -0.56 |
| KIAA1949 | -0.43 | -0.46 |
| TRAF4 | -0.42 | -0.57 |
| FADS2 | -0.42 | -0.51 |
| SH3BP2 | -0.42 | -0.59 |
| CARHSP1 | -0.42 | -0.60 |
| RBMX2 | -0.42 | -0.56 |
| TIGD1 | -0.41 | -0.43 |
| PDE9A | -0.41 | -0.57 |
| ZNF311 | -0.41 | -0.41 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0015464 | acetylcholine receptor activity | TAS | Neurotransmitter (GO term level: 6) | 7619526 |
| GO:0004889 | nicotinic acetylcholine-activated cation-selective channel activity | IMP | 9221765 | |
| GO:0005216 | ion channel activity | TAS | 6688857 | |
| GO:0005230 | extracellular ligand-gated ion channel activity | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0007274 | neuromuscular synaptic transmission | IMP | neuron, Synap (GO term level: 7) | 9221765 |
| GO:0007528 | neuromuscular junction development | IMP | Synap (GO term level: 10) | 9221765 |
| GO:0007165 | signal transduction | TAS | 7619526 | |
| GO:0006811 | ion transport | IEA | - | |
| GO:0006936 | muscle contraction | TAS | 7619526 | |
| GO:0042391 | regulation of membrane potential | IMP | 9221765 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0031594 | neuromuscular junction | IDA | neuron, axon, Synap, Neurotransmitter (GO term level: 3) | 9221765 |
| GO:0005892 | nicotinic acetylcholine-gated receptor-channel complex | TAS | Neurotransmitter (GO term level: 9) | 7619526 |
| GO:0045211 | postsynaptic membrane | IEA | Synap, Neurotransmitter (GO term level: 5) | - |
| GO:0016021 | integral to membrane | IEA | - | |
| GO:0005886 | plasma membrane | IEA | - | |
| GO:0030054 | cell junction | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION | 272 | 195 | All SZGR 2.0 genes in this pathway |
| BIOCARTA第一途径 | 33 | 24 | All SZGR 2.0 genes in this pathway |
| BIOCARTA AGR PATHWAY | 36 | 31 | All SZGR 2.0 genes in this pathway |
| PID ERBB2 ERBB3 PATHWAY | 44 | 35 | All SZGR 2.0 genes in this pathway |
| REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES | 186 | 155 | All SZGR 2.0 genes in this pathway |
| REACTOME NEURONAL SYSTEM | 279 | 221 | All SZGR 2.0 genes in this pathway |
| REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL | 137 | 110 | All SZGR 2.0 genes in this pathway |
| REACTOME ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS | 16 | 13 | All SZGR 2.0 genes in this pathway |
| REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | 13 | 12 | All SZGR 2.0 genes in this pathway |
| REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | 12 | 10 | All SZGR 2.0 genes in this pathway |
| HORIUCHI WTAP TARGETS DN | 310 | 188 | All SZGR 2.0 genes in this pathway |
| SABATES COLORECTAL ADENOMA DN | 291 | 176 | All SZGR 2.0 genes in this pathway |
| KIM WT1 TARGETS 12HR UP | 162 | 116 | All SZGR 2.0 genes in this pathway |
| DELASERNA MYOD TARGETS UP | 89 | 51 | All SZGR 2.0 genes in this pathway |
| HELLER SILENCED BY METHYLATION UP | 282 | 183 | All SZGR 2.0 genes in this pathway |
| BONOME OVARIAN CANCER SURVIVAL OPTIMAL DEBULKING | 246 | 152 | All SZGR 2.0 genes in this pathway |
| BEIER GLIOMA STEM CELL UP | 39 | 17 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 5 DN | 50 | 31 | All SZGR 2.0 genes in this pathway |