Gene Page:TWF2

Summary?
GeneID 11344
Symbol TWF2
Synonyms A6RP|A6r|MSTP011|PTK9L
Description twinfilin actin binding protein 2
Reference MIM:607433|HGNC:HGNC:9621|Ensembl:ENSG00000247596|HPRD:08464|Vega:OTTHUMG00000158105
Gene type protein-coding
Map location 3p21.1
Pascal p-value 1.9E-5
Sherlock p-value 0.799
Fetal beta -0.436
DMG 1 (# studies)
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
LK:YES Genome-wide Association Study This data set included 99 genes mapped to the 22 regions. The 24 leading SNPs were also included in CV:Ripke_2013

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg03897318 3 52272844 TWF2 8.02E-5 0.414 0.025 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
snp_a-4218218 0 TWF2 11344 0.13 trans
rs584108 chr11 68630281 TWF2 11344 0.14 trans
rs596874 chr11 68630873 TWF2 11344 0.06 trans
rs501799 chr11 68631239 TWF2 11344 0.18 trans
rs646586 chr11 68681652 TWF2 11344 0.07 trans
rs478647 chr11 68700423 TWF2 11344 0.19 trans
rs10772528 chr12 12210187 TWF2 11344 0.03 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ACTR3B ARP11 | ARP3BETA | DKFZp686O24114 ARP3 actin-related protein 3 homolog B (yeast) Affinity Capture-MS BioGRID 17353931
CAPZA1 CAPPA1 | CAPZ | CAZ1 capping protein (actin filament) muscle Z-line, alpha 1 Affinity Capture-MS BioGRID 17353931
CAPZA2 CAPPA2 | CAPZ capping protein (actin filament) muscle Z-line, alpha 2 Affinity Capture-MS BioGRID 17353931
CAPZB CAPB | CAPPB | CAPZ | MGC104401 | MGC129749 | MGC129750 capping protein (actin filament) muscle Z-line, beta Affinity Capture-MS BioGRID 17353931
CHGB SCG1 chromogranin B (secretogranin 1) Two-hybrid BioGRID 16169070
ELOVL1 CGI-88 | Ssc1 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1 Affinity Capture-MS BioGRID 17353931
ERC1 Cast2 | ELKS | KIAA1081 | MGC12974 | RAB6IP2 ELKS/RAB6-interacting/CAST family member 1 Affinity Capture-MS BioGRID 17353931
KRT31 HA1 | Ha-1 | KRTHA1 | MGC138630 | hHa1 keratin 31 Affinity Capture-MS BioGRID 17353931
KRT36 HA6 | KRTHA6 | hHa6 keratin 36 Affinity Capture-MS BioGRID 17353931
KRT82 HB2 | Hb-2 | KRTHB2 keratin 82 Affinity Capture-MS BioGRID 17353931
KRT85 HB5 | Hb-5 | KRTHB5 | hHb5 keratin 85 Affinity Capture-MS BioGRID 17353931
LYAR FLJ20425 | ZLYAR Ly1 antibody reactive homolog (mouse) Affinity Capture-MS BioGRID 17353931
VRK3 - vaccinia related kinase 3 Affinity Capture-MS BioGRID 17353931


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493 298 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142 669 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612 367 All SZGR 2.0 genes in this pathway
BORLAK LIVER CANCER EGF UP 57 41 All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM1 229 137 All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM2 153 102 All SZGR 2.0 genes in this pathway
WILLIAMS ESR2 TARGETS UP 28 18 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024 594 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP 487 286 All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN 225 163 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS LATE PROGENITOR 544 307 All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC DN 228 146 All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE DN 261 183 All SZGR 2.0 genes in this pathway
CARDOSO RESPONSE TO GAMMA RADIATION AND 3AB 18 11 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS UP 388 234 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973 570 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863 514 All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING 510 309 All SZGR 2.0 genes in this pathway
MOOTHA PGC 420 269 All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210 725 All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED 351 238 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS 535 325 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 17 181 101 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 4HR DN 254 158 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES 462 273 All SZGR 2.0 genes in this pathway