基因页：adcy9

Summary？
基因 115
象征 adcy9
Synonyms AC9 | Acix
Description 腺苷酸环化酶9
参考erence MIM：603302|HGNC：HGNC：240|ENSEMBL：ENSG00000162104|HPRD：04489|Vega:OTTHUMG00000177612
基因类型 蛋白质编码
Map location 16p13.3
Pascal p-value 0.004
TADA P值 0.026
胎儿β -0.062
DMG 1(# studies)
Support 细胞内信号转导

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:PGCnp 全基因组协会研究 GWAS
DMG：Wockner_2014 全基因组DNA甲基化分析 该数据集包括4641个差异甲基化探针，对应于精神分裂症患者（n = 24）和对照组（n = 24）之间的2929个独特基因。 1
DNM：Gulsuner_2013 整个外显子组测序分析 155 DNM通过外显子组对精神分裂症个体及其父母的三重奏测序确定。

Section I. Genetics and epigenetics annotation

@DNM表

Gene 染色体 位置 参考 alt 成绩单 AA更改 突变类型 筛 CG46 特征 学习
adcy9 CHR16 4033408 t C NM_001116 p.782S>G missense Schizophrenia DNM：Gulsuner_2013

@差异甲基化基因

Probe 染色体 位置 最近的基因 p（dis） Beta (dis) fdr（dis） 学习
CG04737885 16 4014095 adcy9 2.945e-4 -0.388 0.039 DMG：Wockner_2014


第二节。转录组注释

一般基因表达（GTEX）

无法使用

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

前10个积极共表达的基因
Gene 皮尔逊的相关性 斯皮尔曼的相关性
ZFYVE1 0.94 0.95
COPA 0.93 0.94
VPS39 0.93 0.94
KIAA0090 0.93 0.93
PDE12 0.93 0.93
RNF216 0.93 0.93
UBE4B 0.93 0.93
Stard7 0.92 0.92
XPO7 0.92 0.93
GTF3C1 0.92 0.92
前10个负共表达基因
Gene 皮尔逊的相关性 斯皮尔曼的相关性
AF347015.21 -0.81 -0.86
MT-CO2 -0.79 -0.83
AF347015.31 -0.78 -0.82
ifi27 -0.76 -0.78
HIGD1B -0.75 -0.79
AF347015.8 -0.74 -0.80
FXYD1 -0.74 -0.78
mt-cyb -0.74 -0.77
AF347015.27 -0.73 -0.78
AF347015.33 -0.72 -0.75

Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
KEGG PURINE METABOLISM 159 96 All SZGR 2.0 genes in this pathway
kegg钙信号通路 178 134 All SZGR 2.0 genes in this pathway
KEGG趋化因子信号传导途径 190 128 All SZGR 2.0 genes in this pathway
Kegg卵母细胞减数分裂 114 79 All SZGR 2.0 genes in this pathway
KEGG VASCULAR SMOOTH MUSCLE CONTRACTION 115 81 All SZGR 2.0 genes in this pathway
KEGG GAP JUNCTION 90 68 All SZGR 2.0 genes in this pathway
kegg gnRH信号通路 101 77 All SZGR 2.0 genes in this pathway
KEGG孕酮介导的卵母细胞成熟 86 59 All SZGR 2.0 genes in this pathway
KEGG MELANOGENESIS 102 80 All SZGR 2.0 genes in this pathway
KEGG加压素调节的水重吸收 44 30 All SZGR 2.0 genes in this pathway
Kegg Vibrio霍乱感染 56 32 All SZGR 2.0 genes in this pathway
KEGG扩张心肌病 92 68 All SZGR 2.0 genes in this pathway
PID内皮素路径 63 52 All SZGR 2.0 genes in this pathway
PID LYSOPHOSPHOLIPID PATHWAY 66 53 All SZGR 2.0 genes in this pathway
PID LPA4途径 15 10 All SZGR 2.0 genes in this pathway
NGF的Reactome信号传导 217 167 All SZGR 2.0 genes in this pathway
REACTOME DAG AND IP3 SIGNALING 32 25 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB2 101 78 All SZGR 2.0 genes in this pathway
EGFR在癌症中的反应组信号传导 109 80 All SZGR 2.0 genes in this pathway
Reactome NGF信号通过TRKA从质膜发出 137 105 All SZGR 2.0 genes in this pathway
FGFR的Reactome信号传导IN DISEASE 127 88 All SZGR 2.0 genes in this pathway
跨化学突触的反应组传播 186 155 All SZGR 2.0 genes in this pathway
Reactome神经元系统 279 221 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
能量代谢的反应组整合 120 84 All SZGR 2.0 genes in this pathway
Reactome阿片类药物信号传导 78 56 All SZGR 2.0 genes in this pathway
REACTOME CA DEPENDENT EVENTS 30 23 All SZGR 2.0 genes in this pathway
REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY 10 8 All SZGR 2.0 genes in this pathway
反应组腺苷酸环化酶抑制途径 13 9 All SZGR 2.0 genes in this pathway
反应组神经递质受体结合和突触后细胞中的下游传播 137 110 All SZGR 2.0 genes in this pathway
Reactome PLC Beta介导的事件 43 32 All SZGR 2.0 genes in this pathway
REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB 18 14 All SZGR 2.0 genes in this pathway
小分子的反应组跨膜转运 413 270 All SZGR 2.0 genes in this pathway
REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION 34 23 All SZGR 2.0 genes in this pathway
PDGF的Reactome信号传导 122 93 All SZGR 2.0 genes in this pathway
Reactome下游信号转导 95 76 All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805 368 All SZGR 2.0 genes in this pathway
我REACTOME Gα信号事件 195 114 All SZGR 2.0 genes in this pathway
Reactome G alpha的信号事件 121 82 All SZGR 2.0 genes in this pathway
Reactome G alpha z信号事件 44 29 All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR 100 74 All SZGR 2.0 genes in this pathway
Reactome磷脂酶C介导的级联 54 40 All SZGR 2.0 genes in this pathway
Reactome Aquaporin介导的运输 51 34 All SZGR 2.0 genes in this pathway
肾水通道蛋白对水平衡的反应组调节 44 30 All SZGR 2.0 genes in this pathway
Reactome GABA B受体激活 38 26 All SZGR 2.0 genes in this pathway
REACTOME GABA RECEPTOR ACTIVATION 52 40 All SZGR 2.0 genes in this pathway
FGFR的Reactome信号传导 112 80 All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567 375 All SZGR 2.0 genes in this pathway
刘前列腺癌DN 481 290 All SZGR 2.0 genes in this pathway
Onken Uveal黑色素瘤 783 507 All SZGR 2.0 genes in this pathway
Chemnitz对前列腺素E2 DN的反应 391 222 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 UP 380 236 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP 418 263 All SZGR 2.0 genes in this pathway
runx1 runx1t1融合红细胞的TONKS目标 157 104 All SZGR 2.0 genes in this pathway
PAPASPYRIDONOS UNSTABLE ATEROSCLEROTIC PLAQUE DN 43 29 All SZGR 2.0 genes in this pathway
UDayakumar Med1靶向DN 240 171 All SZGR 2.0 genes in this pathway
Gozgit ESR1靶向DN 781 465 All SZGR 2.0 genes in this pathway
ENK UV响应角质形成细胞DN 485 334 All SZGR 2.0 genes in this pathway
LUI甲状腺癌PAX8 PPARG UP 44 29 All SZGR 2.0 genes in this pathway
Dacosta UV响应通过ERCC3 XPCS DN 88 71 All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 5 147 89 All SZGR 2.0 genes in this pathway
LUI甲状腺癌簇1 51 33 All SZGR 2.0 genes in this pathway
Dacosta UV响应通过ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
KIM MYCN AMPLIFICATION TARGETS UP 92 64 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024 594 All SZGR 2.0 genes in this pathway
Frasor对雌二醇的反应 37 28 All SZGR 2.0 genes in this pathway
Ross AML带有MLL融合 78 45 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 All SZGR 2.0 genes in this pathway
伊万诺娃造血干细胞长期 302 191 All SZGR 2.0 genes in this pathway
阿尔茨海默氏病dn 1237 837 All SZGR 2.0 genes in this pathway
DASU IL6信号疤痕向上 30 21 All SZGR 2.0 genes in this pathway
葡萄病毒感染DN的Debiasi凋亡DN 287 208 All SZGR 2.0 genes in this pathway
Dazard对UV NHEK DN的反应 318 220 All SZGR 2.0 genes in this pathway
dazard UV响应集群G6 153 112 All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566 371 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 4 307 185 All SZGR 2.0 genes in this pathway
Heller HDAC靶向 317 208 All SZGR 2.0 genes in this pathway
Heller HDAC靶向被甲基化的沉默 461 298 All SZGR 2.0 genes in this pathway
伽玛辐射2G后的生存率不佳 171 96 All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE DN 258 160 All SZGR 2.0 genes in this pathway
MARZEC IL2 SIGNALING UP 115 80 All SZGR 2.0 genes in this pathway
乳房萧述三CANCER BASAL DN 701 446 All SZGR 2.0 genes in this pathway
Bonome卵巢癌的生存次优秀 510 309 All SZGR 2.0 genes in this pathway
BASSO HAIRY CELL LEUKEMIA DN 80 66 All SZGR 2.0 genes in this pathway
对Salirasib dn的Blum响应 342 220 All SZGR 2.0 genes in this pathway
Ichiba移植与宿主疾病35D DN 49 34 All SZGR 2.0 genes in this pathway
罗斯白血病与MLL融合 78 49 All SZGR 2.0 genes in this pathway
Shedden肺癌良好生存A12 317 177 All SZGR 2.0 genes in this pathway
Valk AML群集16 26 17 All SZGR 2.0 genes in this pathway
YAGI AML WITH T 9 11 TRANSLOCATION 130 87 All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED 351 238 All SZGR 2.0 genes in this pathway
Stein ESR1目标 85 55 All SZGR 2.0 genes in this pathway
Stein雌激素反应不是通过ESRRA 18 12 All SZGR 2.0 genes in this pathway
KOBAYASHI EGFR SIGNALING 24HR UP 101 65 All SZGR 2.0 genes in this pathway
由MYC约束 1103 714 All SZGR 2.0 genes in this pathway
黄成人组织茎模块 721 492 All SZGR 2.0 genes in this pathway
Sasson对促性腺营养蛋白DN的反应 87 66 All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO FORSKOLIN DN 88 68 All SZGR 2.0 genes in this pathway
Dutertre雌二醇反应6小时 229 149 All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS NOT VIA AKT1 UP 211 131 All SZGR 2.0 genes in this pathway
BHAT ESR1通过AKT1 UP目标 281 183 All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP 259 159 All SZGR 2.0 genes in this pathway
ewsr1 fli1融合的骨靶标 271 165 All SZGR 2.0 genes in this pathway
Gobert少突胶质细胞分化DN 1080 713 All SZGR 2.0 genes in this pathway
Fortschegger PHF8靶向DN 784 464 All SZGR 2.0 genes in this pathway