Gene Page:GBP4

Summary?
GeneID 115361
Symbol GBP4
Synonyms Mpa2
Description guanylate binding protein 4
Reference MIM:612466|HGNC:HGNC:20480|Ensembl:ENSG00000162654|HPRD:13570|Vega:OTTHUMG00000010663
Gene type protein-coding
Map location 1p22.2
Pascal p-value 0.958
Sherlock p-value 0.936
DEG p-value DEG:Sanders_2014:DS1_p=0.160:DS1_beta=0.017100:DS2_p=2.50e-03:DS2_beta=-0.141:DS2_FDR=3.02e-02
Fetal beta -0.381
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
DEG:Sanders_2013 Microarray Whole-genome gene expression profiles using microarrays on lymphoblastoid cell lines (LCLs) from 413 cases and 446 controls.

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs2745260 chr1 11586676 GBP4 115361 0.19 trans
rs17109968 chr1 54633542 GBP4 115361 0.16 trans
rs12036740 chr1 58432174 GBP4 115361 0.09 trans
rs12041093 chr1 58462509 GBP4 115361 0.03 trans
rs12023109 chr1 58482942 GBP4 115361 0.03 trans
rs473019 chr1 72296394 GBP4 115361 0.06 trans
rs11799385 chr1 79449863 GBP4 115361 0.13 trans
rs17121311 chr1 100314968 GBP4 115361 0.01 trans
rs1342707 chr1 147264296 GBP4 115361 1.072E-4 trans
rs3766034 chr1 169087664 GBP4 115361 0 trans
rs12748624 chr1 169189770 GBP4 115361 0.06 trans
rs4027083 chr1 234452908 GBP4 115361 0.07 trans
rs10495652 chr2 17139288 GBP4 115361 1.097E-6 trans
rs6531271 chr2 17139932 GBP4 115361 1.097E-6 trans
rs12620194 chr2 17148003 GBP4 115361 1.097E-6 trans
rs17042744 chr2 21824821 GBP4 115361 0.01 trans
rs2113625 chr2 21828617 GBP4 115361 0.01 trans
rs7563186 chr2 21844897 GBP4 115361 1.689E-4 trans
rs17680142 chr2 21849670 GBP4 115361 0.01 trans
rs6547745 chr2 21852551 GBP4 115361 0.01 trans
rs6758775 chr2 21887142 GBP4 115361 0.13 trans
rs17042868 chr2 21895688 GBP4 115361 0.01 trans
rs11893111 chr2 21910980 GBP4 115361 0.01 trans
rs10490050 chr2 40571949 GBP4 115361 0.06 trans
snp_a-2186147 0 GBP4 115361 0.1 trans
rs9860881 chr3 40278954 GBP4 115361 0.19 trans
snp_a-2258988 0 GBP4 115361 0.01 trans
rs17577568 chr5 133167214 GBP4 115361 0.06 trans
rs10491308 chr5 140678473 GBP4 115361 0.03 trans
rs10462960 chr5 166125559 GBP4 115361 0.01 trans
rs2962835 chr5 176331831 GBP4 115361 0.01 trans
rs10516136 chr5 176381368 GBP4 115361 0 trans
rs10069302 chr5 176461594 GBP4 115361 0.05 trans
rs6881260 chr5 176464003 GBP4 115361 0.05 trans
rs6860827 chr5 176479648 GBP4 115361 0.05 trans
rs6887893 chr5 176493262 GBP4 115361 0.05 trans
rs12195984 0 GBP4 115361 0.15 trans
rs16889143 chr6 36757182 GBP4 115361 0.03 trans
rs16869716 chr6 71743471 GBP4 115361 1.585E-6 trans
rs1080960 chr6 84815420 GBP4 115361 0.15 trans
rs13362753 0 GBP4 115361 0.15 trans
rs6455821 chr6 162825101 GBP4 115361 0.11 trans
rs344468 chr7 146419325 GBP4 115361 0.12 trans
rs7790094 chr7 152786528 GBP4 115361 0.12 trans
rs4726262 chr7 152855641 GBP4 115361 0.08 trans
rs6464313 chr7 152855864 GBP4 115361 0.16 trans
rs16932340 chr8 66684243 GBP4 115361 0 trans
rs10827397 chr10 19722202 GBP4 115361 0.01 trans
rs7907015 chr10 19921035 GBP4 115361 0.02 trans
rs10827728 chr10 19930366 GBP4 115361 0.02 trans
rs10509151 chr10 63358651 GBP4 115361 0.12 trans
RS2393827 chr10 63563590 GBP4 115361 7.427E-4 trans
rs2588986 chr10 63568258 GBP4 115361 7.427E-4 trans
rs2053642 chr10 63613118 GBP4 115361 0.01 trans
rs11027580 chr11 23891659 GBP4 115361 0.16 trans
rs11027591 chr11 23900616 GBP4 115361 0.15 trans
rs17133330 chr11 99097728 GBP4 115361 0.07 trans
rs2592926 chr11 127251272 GBP4 115361 0.02 trans
rs2618221 chr11 127251893 GBP4 115361 0.03 trans
rs12577873 chr11 127261987 GBP4 115361 0.02 trans
rs11220901 chr11 127274538 GBP4 115361 0.01 trans
rs10893679 chr11 127281378 GBP4 115361 0.01 trans
rs17395192 chr12 26643930 GBP4 115361 0.03 trans
rs11613629 chr12 104972976 GBP4 115361 0.01 trans
rs6492262 chr13 111000751 GBP4 115361 0 trans
rs7143284 chr14 58320614 GBP4 115361 0.02 trans
rs927248 chr14 58321206 GBP4 115361 0.02 trans
rs11158940 chr14 72522541 GBP4 115361 0.14 trans
rs4774826 chr15 56070006 GBP4 115361 6.758E-6 trans
rs6498459 chr16 13795898 GBP4 115361 0.05 trans
rs16995164 chrX 148536507 GBP4 115361 0.06 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
Reactome干扰素伽马信号传导 63 48 All SZGR 2.0 genes in this pathway
REACTOME INTERFERON SIGNALING 159 116 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270 204 All SZGR 2.0 genes in this pathway
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER UP 206 111 All SZGR 2.0 genes in this pathway
WATANABE ULCERATIVE COLITIS WITH CANCER DN 14 9 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF UP 215 137 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
JECHLINGER EPITHELIAL TO MESENCHYMAL TRANSITION UP 71 51 All SZGR 2.0 genes in this pathway
SANA RESPONSE TO IFNG UP 78 50 All SZGR 2.0 genes in this pathway
YU MYC TARGETS DN 55 38 All SZGR 2.0 genes in this pathway
IGLESIAS E2F TARGETS UP 151 103 All SZGR 2.0 genes in this pathway
HAN JNK SINGALING UP 35 21 All SZGR 2.0 genes in this pathway
LEE AGING CEREBELLUM UP 84 58 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681 420 All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN 409 268 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973 570 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863 514 All SZGR 2.0 genes in this pathway
SEKI INFLAMMATORY RESPONSE LPS UP 77 56 All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP 107 67 All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE 35D UP 131 79 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN 435 289 All SZGR 2.0 genes in this pathway
COLINA TARGETS OF 4EBP1 AND 4EBP2 356 214 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 15 35 23 All SZGR 2.0 genes in this pathway
GREGORY SYNTHETIC LETHAL WITH IMATINIB 145 83 All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS UP 387 225 All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS UP 217 131 All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS GROUP1 136 76 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745 475 All SZGR 2.0 genes in this pathway
SERVITJA ISLET HNF1A TARGETS UP 163 111 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658 397 All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP 364 236 All SZGR 2.0 genes in this pathway
BOSCO INTERFERON INDUCED ANTIVIRAL MODULE 78 48 All SZGR 2.0 genes in this pathway
ALTEMEIER RESPONSE TO LPS WITH MECHANICAL VENTILATION 128 81 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725 838 All SZGR 2.0 genes in this pathway