Gene Page:GRIN3B

Summary?
GeneID 116444
Symbol GRIN3B
Synonyms GluN3B|NR3B
Description glutamate ionotropic receptor NMDA type subunit 3B
Reference MIM:606651|HGNC:HGNC:16768|Ensembl:ENSG00000116032|Vega:OTTHUMG00000181904
Gene type protein-coding
Map location 19p13.3
Pascal p-value 0.131
Fetal beta -0.472
eGene 小脑
支持 Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 8

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0004970 ionotropic glutamate receptor activity IEA glutamate (GO term level: 7) -
GO:0005234 extracellular-glutamate-gated ion channel activity IEA glutamate (GO term level: 11) -
GO:0000287 magnesium ion binding IEA -
GO:0004872 receptor activity IEA -
GO:0005509 calcium ion binding IEA -
GO:0005262 calcium channel activity IEA -
GO:0005262 calcium channel activity ISS 11735224
GO:0005216 ion channel activity IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0006811 ion transport IEA -
GO:0051205 protein insertion into membrane IEA -
GO:0051205 protein insertion into membrane ISS 11735224
GO:0051924 regulation of calcium ion transport IEA -
GO:0051924 regulation of calcium ion transport ISS 11735224
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0043025 cell soma IEA axon, dendrite (GO term level: 4) -
GO:0043025 cell soma ISS axon, dendrite (GO term level: 4) 11735224
GO:0017146 N-methyl-D-aspartate selective glutamate receptor complex IEA glutamate, Synap (GO term level: 10) -
GO:0017146 N-methyl-D-aspartate selective glutamate receptor complex ISS glutamate, Synap (GO term level: 10) 11735224
GO:0017146 N-methyl-D-aspartate selective glutamate receptor complex NAS glutamate, Synap (GO term level: 10) 11735224
GO:0045211 postsynaptic membrane IEA Synap, Neurotransmitter (GO term level: 5) -
GO:0045202 synapse IEA neuron, Synap, Neurotransmitter, Glial (GO term level: 2) -
GO:0016021 integral to membrane IEA -
GO:0005886 plasma membrane IEA -
GO:0030054 cell junction IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272 195 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552 347 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536 296 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K27ME3 269 159 All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435 318 All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590 403 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857 456 All SZGR 2.0 genes in this pathway