SZGR2 - Beplay体育中心

Summary?

基因ID	1191
Symbol	CLU
同义词	AAG4\|APO-J\|APOJ\|CLI\|CLU1\|CLU2\|KUB1\|NA1/NA2\|SGP-2\|SGP2\|SP-40\|TRPM-2\|TRPM2
描述	clusterin
参考	MIM:185430\|HGNC：HGNC：2095\|Ensembl:ENSG00000120885\|HPRD:01706\|Vega：Otthumg00000102114
基因type	protein-coding
地图位置	8p21-p12
Pascal P值	8.35e-6
Sherlock P值	0.932
Fetal beta	-1.647
DMG	1(#研究)
支持	G2CDB.HUMAN_BAYES-COLLINS-HUMAN-PSD-CONSESUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS CompositeSet

基因in Data Sources

基因set name	基因组方法	描述	Info
CV:GWAScat	全基因组关联研究	This data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:GWASdb	全基因组关联研究	gwasdbrecords for schizophrenia
简历：PGC128	全基因组协会研究	多达36,989例和113,075个对照的多阶段精神分裂症GWA。由PGC的精神分裂症工作组报告。128个跨越108个基因座的独立协会
简历：PGCNP	全基因组协会研究	GWAS
DMG:Jaffe_2016	Genome-wide DNA methylation analysis	该数据集包括与SZ患者相关的2,104个探针/CPG（n = 108），而在Bonferroni调整后的P <0.05时，其中136个对照。	1
PMID:cooccur	高通量文献搜索	系统ematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I	Genome scan meta-analysis	Psr: 0.031
GSMA_IIE	Genome scan meta-analysis (European-ancestry samples)	PSR：0.00057
GSMA_IIA	基因组扫描荟萃分析（所有样品）	Psr: 0.03086
Literature	高通量文献搜索	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
网络	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 1.2915

Section I. Genetics and epigenetics annotation

简历：PGC128

SNP ID	Chromosome	Position	等位基因	P	Function	基因	Up/Down Distance
RS73229090	chr8	27442127	AC	1.952E-8	intergenic	EPHX2,CLU	dist = 39688; dist = 12307

差异甲基化基因

探测	Chromosome	Position	最近的基因	P (dis)	beta（dis）	FDR (dis)	Study
cg04929736	8	27472395	CLU	6.26e-12	-0.013	1.84E-7	DMG:Jaffe_2016

Section II. Transcriptome annotation

基因ral gene expression (GTEx)

Devlopment期间的基因表达（BrainCloud）

Footnote:
总共绘制了269个时间点，n = 38个胎儿样品（x = 1：38）。每个三角形代表一个时间点。

基因expression of temporal and spatial changes (BrainSpan)

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

前10个积极共表达的基因
基因	皮尔逊的相关性	斯皮尔曼的相关性
KCNJ10	0.92	0.93
GPRC5B	0.91	0.90
PAQR8	0.91	0.93
GM2A	0.90	0.93
C5orf4	0.89	0.91
CDH20	0.89	0.89
SASH1	0.88	0.87
WFS1	0.86	0.86
IGSF11	0.86	0.89
aldh6a1	0.86	0.87

前10个负共表达基因
基因	皮尔逊的相关性	斯皮尔曼的相关性
MED19	-0.56	-0.60
NR2C2AP	-0.54	-0.57
POLB	-0.54	-0.59
STMN1	-0.53	-0.51
TCTEX1D2	-0.52	-0.58
AIM2	-0.52	-0.59
ALKBH2	-0.52	-0.57
TRNAU1AP	-0.52	-0.53
STMN2	-0.52	-0.47
CYP2R1	-0.51	-0.57

Section III. Gene Ontology annotation

Molecular function	去的术语	Evidence	Neuro keywords	PubMed ID
GO:0005515	protein binding	新闻学会		17043677
Biological process	去的术语	Evidence	Neuro keywords	PubMed ID
去：0008219	cell death	IEA		-
GO:0006958	complement activation, classical pathway	IEA		-
GO:0006629	lipid metabolic process	NAS		2387851
GO:0006915	apoptosis	IEA		-
GO:0045087	innate immune response	IEA		-
细胞分量	去的术语	Evidence	Neuro keywords	PubMed ID
GO:0005576	extracellular region	IEA		-
GO:0005615	细胞外空间	NAS		14718574

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
C7	-	补体组件7	-	HPRD，Biogrid	8345200
C8B	MGC163447	complement component 8, beta polypeptide	-	HPRD，Biogrid	8345200
C9	-	补体组件9	-	HPRD，Biogrid	8345200
CLU	AAG4 \| APOJ \| CLI \| KUB1 \| MGC24903 \| SGP-2 \| SGP2 \| SP-40 \| TRPM-2 \| TRPM2	clusterin	-	HPRD，Biogrid	12551933
CLU	AAG4 \| APOJ \| CLI \| KUB1 \| MGC24903 \| SGP-2 \| SGP2 \| SP-40 \| TRPM-2 \| TRPM2	clusterin	CLU与CLU相互作用。这种相互作用是在人类CLU和小鼠CLU之间的相互作用上建模的。	BIND	12551933
CLUAP1	FLJ13297 \|KIAA0643	clusterin associated protein 1	CLUAP1 interacts with nCLU.	BIND	15480429
LEP	FLJ94114 \|OB \|obs	leptin	-	HPRD，Biogrid	12824284
LEPR	CD295 \|OBR	leptin receptor	-	HPRD	12824284
LRP2	DBS \| gp330	low density lipoprotein-related protein 2	-	HPRD，Biogrid	7768901
LRP8	APOER2 \| HSZ75190 \| MCI1	低密度脂蛋白受体相关蛋白8，载脂蛋白E受体	-	HPRD	12824284
MMP25	MMP20 \| MMP20A \| MMPL1 \| MT-MMP6 \| MT6-MMP	matrix metallopeptidase 25	-	HPRD，Biogrid	12860995
pon1	ESA \|pon	paraoxonase 1	-	HPRD	8292612
prnp	ascr \|CD230 \|CJD \|GSS \|MGC26679 \|prip \|prp \|PRP27-30 \|PRP33-35C \|PRPC \| prion	prion蛋白	-	HPRD	15146195
TGFBR1	AAT5 \| ACVRLK4 \| ALK-5 \| ALK5 \| LDS1A \| LDS2A \| SKR4 \| TGFR-1	转化生长因子，β受体1	-	HPRD，Biogrid	8555189
TGFBR1	AAT5 \| ACVRLK4 \| ALK-5 \| ALK5 \| LDS1A \| LDS2A \| SKR4 \| TGFR-1	转化生长因子，β受体1	APOJ与TGFBR1相互作用。	BIND	8555189
TGFBR2	AAT3 \| FAA3 \| LDS1B \| LDS2B \| MFS2 \| RIIC \| TAAD2 \| TGFR-2 \| TGFbeta-RII	转化生长因子，β受体II（70/80KDA）	-	HPRD，Biogrid	8555189
TGFBR2	AAT3 \| FAA3 \| LDS1B \| LDS2B \| MFS2 \| RIIC \| TAAD2 \| TGFR-2 \| TGFbeta-RII	转化生长因子，β受体II（70/80KDA）	APOJ与TGFBR2相互作用。	BIND	8555189
vldlr	chrmq1 \|FLJ35024 \|vldlrch	very low density lipoprotein receptor	-	HPRD，Biogrid	12824284
XRCC6	CTC75 \|CTCBF \|G22P1 \|ku70 \|ML8 \|TLAA	X-ray repair complementing defective repair in Chinese hamster cells 6	-	HPRD，Biogrid	10219089
XRCC6	CTC75 \|CTCBF \|G22P1 \|ku70 \|ML8 \|TLAA	X-ray repair complementing defective repair in Chinese hamster cells 6	CLU与G22P1（KU70）相互作用。	BIND	12551933

Section V. Pathway annotation

Pathway name	Pathway size	＃szgr 2.0基因	Info
PID MYC REPRESS PATHWAY	63	52	All SZGR 2.0 genes in this pathway
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	89	56	All SZGR 2.0 genes in this pathway
反应组止血	466	331	All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION	208	138	All SZGR 2.0 genes in this pathway
Piccaluga血管免疫细胞淋巴瘤	205	140	All SZGR 2.0 genes in this pathway
刘前列腺癌DN	481	290	All SZGR 2.0 genes in this pathway
KIM对TSA和Decitabine的反应	129	73	All SZGR 2.0 genes in this pathway
CASORELLI APL SECONDARY VS DE NOVO UP	39	25	All SZGR 2.0 genes in this pathway
NOJIMA SFRP2 TARGETS UP	31	23	All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY DN	367	220	All SZGR 2.0 genes in this pathway
Smirnov在癌症中循环内皮细胞	158	103	All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D DN	205	127	All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS DN	232	139	All SZGR 2.0 genes in this pathway
SENESE HDAC2 TARGETS DN	133	77	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 2HR DN	88	53	All SZGR 2.0 genes in this pathway
剑麻结肠直肠腺瘤DN	291	176	All SZGR 2.0 genes in this pathway
Bidus转移DN	161	93	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP	1821年	933	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN	805	505	All SZGR 2.0 genes in this pathway
Gozgit ESR1靶向DN	781	465	All SZGR 2.0 genes in this pathway
Provenzani转移DN	136	94	All SZGR 2.0 genes in this pathway
lau凋亡CDKN2A UP	55	40	All SZGR 2.0 genes in this pathway
环氧化物素的浓凋亡	239	157	All SZGR 2.0 genes in this pathway
Gaussmann MLL AF4融合靶向E	97	60	All SZGR 2.0 genes in this pathway
王·巴雷特（Wang Barretts）食道	51	27	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 3 4WK UP	214	144	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 5 6WK UP	116	68	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL TGFB1 TARGETS UP	169	127	All SZGR 2.0 genes in this pathway
BUSA SAM68 TARGETS DN	6	5	All SZGR 2.0 genes in this pathway
HWANG PROSTATE CANCER MARKERS	28	19	All SZGR 2.0 genes in this pathway
Perez TP63目标	355	243	All SZGR 2.0 genes in this pathway
农民乳腺癌根源与腔内	326	213	All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS BASAL	330	217	All SZGR 2.0 genes in this pathway
LUND SILENCED BY METHYLATION	16	12	All SZGR 2.0 genes in this pathway
PATTERSON DOCETAXEL RESISTANCE	29	20	All SZGR 2.0 genes in this pathway
NAISHIRO CTNNB1 TARGETS WITH LEF1 MOTIF	8	7	All SZGR 2.0 genes in this pathway
SEITZ NEOPLASTIC TRANSFORMATION BY 8P DELETION UP	73	47	All SZGR 2.0 genes in this pathway
沙诺田顺铂耐药性DN	51	38	All SZGR 2.0 genes in this pathway
牛津·拉拉（Oxford Rala）和拉尔布（Ralb）目标DN	9	5	All SZGR 2.0 genes in this pathway
牛津拉拉或拉尔布靶向DN	24	17	All SZGR 2.0 genes in this pathway
WOOD EBV EBNA1 TARGETS UP	110	71	All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP	414	287	All SZGR 2.0 genes in this pathway
JOHANSSON BRAIN CANCER EARLY VS LATE DN	45	35	All SZGR 2.0 genes in this pathway
Gruetzmann胰腺癌DN	203	134	All SZGR 2.0 genes in this pathway
Tomlins前列腺癌DN	40	33	All SZGR 2.0 genes in this pathway
Ingram SHH靶向DN	64	41	All SZGR 2.0 genes in this pathway
buytaert光动力疗法压力	811	508	All SZGR 2.0 genes in this pathway
Schaeffer前列腺开发48小时	487	286	All SZGR 2.0 genes in this pathway
RICKMAN HEAD AND NECK CANCER D	37	14	All SZGR 2.0 genes in this pathway
WU CELL MIGRATION	184	114	All SZGR 2.0 genes in this pathway
gotzmann上皮到间充质过渡	69	55	All SZGR 2.0 genes in this pathway
Sakai慢性肝炎与肝癌DN	36	24	All SZGR 2.0 genes in this pathway
Collis PRKDC监管机构	15	10	All SZGR 2.0 genes in this pathway
Gnatenko血小板签名	48	28	All SZGR 2.0 genes in this pathway
SANA TNF信号DN	90	57	All SZGR 2.0 genes in this pathway
tarte浆细胞与Plasmablast向上	398	262	All SZGR 2.0 genes in this pathway
Frasor对雌二醇DN的反应	82	52	All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT OK VS DONOR UP	151	100	All SZGR 2.0 genes in this pathway
SHIPP DLBCL VS FOLLICULAR LYMPHOMA DN	45	28	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP	555	346	All SZGR 2.0 genes in this pathway
ALCALAY AML BY NPM1 LOCALIZATION UP	140	83	All SZGR 2.0 genes in this pathway
LEI MYB目标	318	215	All SZGR 2.0 genes in this pathway
GERY CEBP目标	126	90	All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED UP	183	111	All SZGR 2.0 genes in this pathway
Petrova内皮淋巴与血液DN	162	102	All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 UP	182	119	All SZGR 2.0 genes in this pathway
Affar YY1目标	214	133	All SZGR 2.0 genes in this pathway
中岛肥大细胞	46	34	All SZGR 2.0 genes in this pathway
牙肺纹状横纹肌肉瘤DN	408	274	All SZGR 2.0 genes in this pathway
阿尔茨海默氏症疾病初期	390	242	All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS UP	175	116	All SZGR 2.0 genes in this pathway
糖尿病性肾病	86	48	All SZGR 2.0 genes in this pathway
Kang氟尿嘧啶抵抗	22	15	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
Chiba对TSA的反应	50	31	All SZGR 2.0 genes in this pathway
CHEN LVAD SUPPORT OF FAILING HEART UP	103	69	All SZGR 2.0 genes in this pathway
gajate对trabectedin的反应	67	45	All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS BY HNE AND TBH	60	42	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 UP	428	266	All SZGR 2.0 genes in this pathway
KEEN RESPONSE TO ROSIGLITAZONE DN	106	68	All SZGR 2.0 genes in this pathway
ABE INNER EAR	48	26	All SZGR 2.0 genes in this pathway
JI RESPONSE TO FSH UP	74	56	All SZGR 2.0 genes in this pathway
JOSEPH RESPONSE TO SODIUM BUTYRATE UP	31	21	All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS DN	314	188	All SZGR 2.0 genes in this pathway
肺癌和巨噬细胞的钟分泌组	77	50	All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND ENDOTHELIUM	66	47	All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND FIBROBLAST	132	93	All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE DN	373	196	All SZGR 2.0 genes in this pathway
HILLION HMGA1 TARGETS	90	71	All SZGR 2.0 genes in this pathway
HILLION HMGA1B TARGETS	92	68	All SZGR 2.0 genes in this pathway
Lein星形胶质细胞标记	42	35	All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION UP	282	183	All SZGR 2.0 genes in this pathway
Martinez RB1靶向DN	543	317	All SZGR 2.0 genes in this pathway
Martinez TP53目标DN	593	372	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN	591	366	All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE UP	299	167	All SZGR 2.0 genes in this pathway
Sarrio上皮间质转变DN	154	101	All SZGR 2.0 genes in this pathway
克拉斯的iwanaga致癌作用	170	107	All SZGR 2.0 genes in this pathway
OUYANG PROSTATE CANCER MARKERS	19	16	All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR DN	191	123	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP	476	285	All SZGR 2.0 genes in this pathway
ZHENG GLIOBLASTOMA PLASTICITY UP	250	168	All SZGR 2.0 genes in this pathway
Zheng胶质母细胞瘤可塑性DN	58	39	All SZGR 2.0 genes in this pathway
mirlet7a3的Brueckner目标	111	69	All SZGR 2.0 genes in this pathway
PODAR RESPONSE TO ADAPHOSTIN UP	147	98	All SZGR 2.0 genes in this pathway
Qi Plasmacytoma Up	259	185	All SZGR 2.0 genes in this pathway
Cromer肿瘤发生DN	51	29	All SZGR 2.0 genes in this pathway
在肿瘤血管生成期间沉默的Hellebrekers	80	56	All SZGR 2.0 genes in this pathway
Takeer吉西他滨抗性DN	122	84	All SZGR 2.0 genes in this pathway
RUIZ TNC TARGETS UP	153	107	All SZGR 2.0 genes in this pathway
甜肺癌克拉斯	491	316	All SZGR 2.0 genes in this pathway
张TLX目标60小时	293	203	All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS UP	395	249	All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES	389	245	All SZGR 2.0 genes in this pathway
Liu Vav3前列腺致癌DN	17	14	All SZGR 2.0 genes in this pathway
Valk AML群集2	29	14	All SZGR 2.0 genes in this pathway
YAO对孕酮簇6的时间反应6	75	48	All SZGR 2.0 genes in this pathway
国外RB1增长目标	243	155	All SZGR 2.0 genes in this pathway
Chicas RB1目标汇合	567	365	All SZGR 2.0 genes in this pathway
DEMAGALHAES AGING UP	55	39	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP	504	321	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP	430	288	All SZGR 2.0 genes in this pathway
DELPUECH FOXO3 TARGETS UP	68	49	All SZGR 2.0 genes in this pathway
Lee BMP2目标	745	475	All SZGR 2.0 genes in this pathway
DALESSIO TSA RESPONSE	29	16	All SZGR 2.0 genes in this pathway
FEVR CTNNB1靶向	682	433	All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3	824	528	All SZGR 2.0 genes in this pathway
Wang Thoc1靶向DN	20	14	All SZGR 2.0 genes in this pathway
Huang GATA2靶向DN	72	52	All SZGR 2.0 genes in this pathway
PLASARI NFIC TARGETS BASAL UP	27	17	All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS DN	418	245	All SZGR 2.0 genes in this pathway
PECE MAMMARY STEM CELL UP	146	75	All SZGR 2.0 genes in this pathway
前列腺癌模型中的Acevedo FGFR1靶标	289	184	All SZGR 2.0 genes in this pathway
Hecker IFNB1目标	95	54	All SZGR 2.0 genes in this pathway

第六节。microRNA注释

miRNA family	目标位置			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-217	890	896	1a	hsa-miR-217	UACUGCAUCAGGAACUGAUUGGAU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Clickhere看到深圳的列表相关的microrna。
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Clickhereto see the list of brain related miRNAs.

基因页：CLU