Gene Page:CLK1

Summary?
GeneID 1195
Symbol CLK1
Synonyms CLK|CLK/STY|STY
Description CDC like kinase 1
Reference MIM:601951|HGNC:HGNC:2068|Ensembl:ENSG00000013441|HPRD:09058|Vega:OTTHUMG00000132784
Gene type protein-coding
Map location 2q33
Pascal p-value 0.325
Sherlock p-value 0.003
Fetal beta 2.167
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs10937121 chr3 183021268 CLK1 1195 0.05 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
BCLAF1 BTF | KIAA0164 | bK211L9.1 BCL2-associated转录因子1 Two-hybrid BioGRID 12890497
CROP LUC7A | OA48-18 cisplatin resistance-associated overexpressed protein Biochemical Activity BioGRID 12565863
MBP MGC99675 myelin basic protein - HPRD 8798720
NCOR1 KIAA1047 | MGC104216 | N-CoR | TRAC1 | hCIT529I10 | hN-CoR nuclear receptor co-repressor 1 Two-hybrid BioGRID 12890497
PPIG CARS-Cyp | CYP | MGC133241 | SRCyp peptidylprolyl isomerase G (cyclophilin G) Clk interacts with CARS-Cyp. This interaction is modeled on a demonstrated interaction between Clk and CARS-Cyp from mouse. BIND 8973360
PRPF4 HPRP4 | HPRP4P | PRP4 | Prp4p PRP4 pre-mRNA processing factor 4 homolog (yeast) - HPRD,BioGRID 11418604
SAFB DKFZp779C1727 | HAP | HET | SAFB1 scaffold attachment factor B Two-hybrid BioGRID 12890497
SFRS1 ASF | MGC5228 | SF2 | SF2p33 | SRp30a splicing factor, arginine/serine-rich 1 Biochemical Activity BioGRID 8798720|12565863
SFRS1 ASF | MGC5228 | SF2 | SF2p33 | SRp30a splicing factor, arginine/serine-rich 1 - HPRD 8617202
SFRS3 SRp20 splicing factor, arginine/serine-rich 3 Two-hybrid BioGRID 12890497
SFRS6 B52 | FLJ08061 | MGC5045 | SRP55 splicing factor, arginine/serine-rich 6 - HPRD 12549978
UBL5 FLJ46917 | HUB1 | MGC131795 ubiquitin-like 5 Reconstituted Complex BioGRID 12705895


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN 634 384 All SZGR 2.0 genes in this pathway
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA DN 136 86 All SZGR 2.0 genes in this pathway
PRAMOONJAGO SOX4 TARGETS UP 52 38 All SZGR 2.0 genes in this pathway
NOJIMA SFRP2 TARGETS UP 31 23 All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS BLACK UP 35 22 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530 342 All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA DN 394 258 All SZGR 2.0 genes in this pathway
TOMIDA METASTASIS DN 18 11 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 UP 309 199 All SZGR 2.0 genes in this pathway
AMUNDSON RESPONSE TO ARSENITE 217 143 All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO IONIZING RADIATION 149 101 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893 528 All SZGR 2.0 genes in this pathway
MORI PRE BI LYMPHOCYTE DN 77 49 All SZGR 2.0 genes in this pathway
IGLESIAS E2F TARGETS UP 151 103 All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314 201 All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP 262 186 All SZGR 2.0 genes in this pathway
HENDRICKS SMARCA4 TARGETS DN 53 34 All SZGR 2.0 genes in this pathway
MCCLUNG COCAIN REWARD 4WK 75 47 All SZGR 2.0 genes in this pathway
YIH RESPONSE TO ARSENITE C1 24 14 All SZGR 2.0 genes in this pathway
JIANG AGING HYPOTHALAMUS UP 47 31 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
RIGGINS TAMOXIFEN RESISTANCE DN 220 147 All SZGR 2.0 genes in this pathway
STEARMAN LUNG CANCER EARLY VS LATE UP 125 89 All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION DN 105 67 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN 292 189 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281 179 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673 430 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593 372 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN 591 366 All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP 439 257 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425 298 All SZGR 2.0 genes in this pathway
PODAR RESPONSE TO ADAPHOSTIN UP 147 98 All SZGR 2.0 genes in this pathway
CHEN HOXA5 TARGETS 9HR UP 223 132 All SZGR 2.0 genes in this pathway
WINTER HYPOXIA METAGENE 242 168 All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS DN 210 128 All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721 492 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 2 86 50 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN 505 328 All SZGR 2.0 genes in this pathway
ALFANO MYC TARGETS 239 156 All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 2HR UP 53 33 All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 6HR UP 166 97 All SZGR 2.0 genes in this pathway
ZWANG CLASS 2 TRANSIENTLY INDUCED BY EGF 51 29 All SZGR 2.0 genes in this pathway