Gene Page:CPXM2
Summary?
| GeneID | 119587 |
| Symbol | CPXM2 |
| Synonyms | CPX2 | UNQ676 |
| Description | carboxypeptidase X (M14 family), member 2 |
| Reference | HGNC:HGNC:26977|Ensembl:ENSG00000121898|HPRD:08517|Vega:OTTHUMG00000019206 |
| Gene type | protein-coding |
| Map location | 10q26.13 |
| Pascal p-value | 0.176 |
| Fetal beta | -1.505 |
| DMG | 1 (# studies) |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 2 |
| GSMA_IIA | Genome scan meta-analysis (All samples) | Psr: 0.03487 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Differentially methylated gene| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg16197717 | 10 | 125650957 | CPXM2 | 1.12E-5 | -0.373 | 0.013 | DMG:Wockner_2014 |
| cg14676407 | 10 | 125651370 | CPXM2 | 2.56E-5 | -0.479 | 0.017 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs7540312 | chr1 | 43299535 | CPXM2 | 119587 | 0.07 | trans | ||
| rs17131472 | chr1 | 91962966 | CPXM2 | 119587 | 0.03 | trans | ||
| rs2976809 | chr3 | 125451738 | CPXM2 | 119587 | 0.02 | trans | ||
| rs16889842 | chr4 | 9872012 | CPXM2 | 119587 | 0.2 | trans | ||
| rs10050805 | chr5 | 30805352 | CPXM2 | 119587 | 0.09 | trans | ||
| rs12663450 | chr6 | 38135729 | CPXM2 | 119587 | 0.13 | trans | ||
| rs6455226 | chr6 | 67930295 | CPXM2 | 119587 | 0 | trans | ||
| rs3823550 | chr7 | 137346101 | CPXM2 | 119587 | 0.19 | trans | ||
| rs7081666 | chr10 | 47673800 | CPXM2 | 119587 | 0.11 | trans | ||
| rs10879027 | chr12 | 70237156 | CPXM2 | 119587 | 0.12 | trans | ||
| rs6095741 | chr20 | 48666589 | CPXM2 | 119587 | 6.547E-7 | trans | ||
| rs5991662 | chrX | 43335796 | CPXM2 | 119587 | 0 | trans | ||
| rs1545676 | chrX | 93530472 | CPXM2 | 119587 | 0.04 | trans | ||
| rs242163 | chrX | 132311662 | CPXM2 | 119587 | 0.11 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SAP130 | 0.96 | 0.97 |
| QRICH1 | 0.95 | 0.95 |
| PRR3 | 0.95 | 0.96 |
| PHF12 | 0.94 | 0.94 |
| FBXO42 | 0.94 | 0.95 |
| LSM14B | 0.94 | 0.96 |
| NCOA6 | 0.94 | 0.96 |
| ZNF317 | 0.94 | 0.94 |
| ZNF384 | 0.94 | 0.95 |
| SEC24C | 0.94 | 0.94 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.31 | -0.80 | -0.91 |
| MT-CO2 | -0.79 | -0.92 |
| AF347015.27 | -0.79 | -0.91 |
| AF347015.33 | -0.78 | -0.89 |
| MT-CYB | -0.76 | -0.88 |
| S100B | -0.76 | -0.87 |
| AF347015.8 | -0.76 | -0.90 |
| FXYD1 | -0.76 | -0.88 |
| COPZ2 | -0.75 | -0.83 |
| AIFM3 | -0.74 | -0.79 |
Section III. Gene Ontology annotation
| Molecular function | 去的术语 | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004181 | metallocarboxypeptidase activity | IEA | - | |
| GO:0008270 | zinc ion binding | IEA | - | |
| Biological process | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0007155 | cell adhesion | IEA | - | |
| GO:0006508 | proteolysis | IEA | - | |
| Cellular component | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0005576 | extracellular region | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| MARKEY RB1 ACUTE LOF UP | 215 | 137 | All SZGR 2.0 genes in this pathway |
| COWLING MYCN TARGETS | 43 | 27 | All SZGR 2.0 genes in this pathway |
| SCHAEFFER PROSTATE DEVELOPMENT 48HR DN | 428 | 306 | All SZGR 2.0 genes in this pathway |
| LINDVALL IMMORTALIZED BY TERT DN | 80 | 56 | All SZGR 2.0 genes in this pathway |
| ACEVEDO METHYLATED IN LIVER CANCER DN | 940 | 425 | All SZGR 2.0 genes in this pathway |
| MEISSNER NPC HCP WITH H3K4ME2 | 491 | 319 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF HCP WITH H3K27ME3 | 590 | 403 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP A | 898 | 516 | All SZGR 2.0 genes in this pathway |
| LEE BMP2 TARGETS UP | 745 | 475 | All SZGR 2.0 genes in this pathway |