Gene Page:TPP1

概括?
基因 1200
Symbol TPP1
Synonyms CLN2|GIG1|LPIC|SCAR7|TPP-1
Description 三肽基肽酶I。
Reference MIM:607998|HGNC:HGNC:2073|Ensembl:ENSG00000166340|HPRD:06415|Vega:OTTHUMG00000133404
Gene type protein-coding
Map location 11p15
Pascal p-value 0.004
Sherlock p-value 0.184

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 2

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SLC22A17 0.90 0.90
CTSD 0.89 0.90
GBA 0.89 0.90
ACO2 0.88 0.86
GPI 0.88 0.84
PIGT 0.87 0.86
PEBP1 0.87 0.87
AP001107.1 0.87 0.90
ATP6V0C 0.86 0.89
PSAP 0.85 0.84
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
FAM159B -0.51 -0.67
EIF5B -0.51 -0.57
AC005921.3 -0.50 -0.64
NSBP1 -0.48 -0.45
RP9P -0.46 -0.53
KCNMB3 -0.46 -0.43
AC010300.1 -0.44 -0.44
AC011475.1 -0.44 -0.49
RBMX2 -0.43 -0.49
AC135724.1 -0.43 -0.41

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0004252 serine-type endopeptidase activity IEA glutamate (GO term level: 7) -
GO:0005515 protein binding 新闻学会 12134079
GO:0008240 tripeptidyl-peptidase activity IDA 10965052|11054422|12134079
GO:0008240 tripeptidyl-peptidase activity IMP 10617131|10679303
GO:0008240 tripeptidyl-peptidase activity ISS 14609438
GO:0008233 peptidase activity IMP 9295267
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007399 nervous system development IMP neurite (GO term level: 5) 9295267
GO:0006508 proteolysis IMP 9295267|10965052
GO:0007040 lysosome organization IEA -
GO:0006629 lipid metabolic process TAS 9295267
GO:0050885 neuromuscular process controlling balance IEA -
GO:0030163 protein catabolic process NAS 10740217
GO:0043171 peptide catabolic process IMP 9989590|15158442
GO:0045453 骨吸收 IMP 8215436
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005625 soluble fraction IDA 12134079
GO:0005739 mitochondrion IEA -
GO:0005764 lysosome IDA 15317752
GO:0005764 lysosome IMP 9295267
GO:0042470 melanosome IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG LYSOSOME 121 83 All SZGR 2.0 genes in this pathway
REACTOME DIABETES PATHWAYS 133 91 All SZGR 2.0 genes in this pathway
XBP1对伴侣基因的反应组激活 46 34 All SZGR 2.0 genes in this pathway
REACTOME UNFOLDED PROTEIN RESPONSE 80 51 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN 526 357 All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP 473 314 All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP 423 283 All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS UP 306 188 All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP 404 246 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 UP 380 236 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP 418 263 All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS UP 457 269 All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP 501 327 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142 669 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612 367 All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA DN 394 258 All SZGR 2.0 genes in this pathway
HEIDENBLAD AMPLICON 8Q24 DN 46 28 All SZGR 2.0 genes in this pathway
AMUNDSON RESPONSE TO ARSENITE 217 143 All SZGR 2.0 genes in this pathway
BASSO B LYMPHOCYTE NETWORK 143 96 All SZGR 2.0 genes in this pathway
WIELAND UP BY HBV INFECTION 101 66 All SZGR 2.0 genes in this pathway
ROSS AML WITH MLL FUSIONS 78 45 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND UP 77 52 All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS BY TBH AND H2O2 36 24 All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN 408 274 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830 547 All SZGR 2.0 genes in this pathway
CHIBA RESPONSE TO TSA 50 31 All SZGR 2.0 genes in this pathway
BRACHAT RESPONSE TO CAMPTOTHECIN UP 28 18 All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS DN 314 188 All SZGR 2.0 genes in this pathway
DURCHDEWALD SKIN CARCINOGENESIS DN 264 168 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 4 307 185 All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION DN 105 67 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN 292 189 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281 179 All SZGR 2.0 genes in this pathway
TOOKER GEMCITABINE RESISTANCE UP 79 40 All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION D 68 44 All SZGR 2.0 genes in this pathway
RUIZ TNC TARGETS UP 153 107 All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER GOOD SURVIVAL A12 317 177 All SZGR 2.0 genes in this pathway
COLINA TARGETS OF 4EBP1 AND 4EBP2 356 214 All SZGR 2.0 genes in this pathway
KOBAYASHI EGFR SIGNALING 24HR UP 101 65 All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 718 401 All SZGR 2.0 genes in this pathway
MIKKELSEN NPC ICP WITH H3K4ME3 445 257 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP 430 288 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-130/301 1583 1589 m8 hsa-miR-130abrain CAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301 CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrain Cagugcaaugaagggauggau
hsa-miR-454-3p UAGUGCAAUAUUGCUUAUAGGGUUU
miR-149 797 803 1A hsa-miR-149brain UCUGGCUCCGUGUCUUCACUCC