Gene Page:CCR1

Summary?
GeneID 1230
Symbol CCR1
Synonyms CD191|CKR-1|CKR1|CMKBR1|HM145|MIP1aR|SCYAR1
Description C-C motif chemokine receptor 1
Reference MIM:601159|HGNC:HGNC:1602|Ensembl:ENSG00000163823|HPRD:03101|Vega:OTTHUMG00000133451
Gene type protein-coding
Map location 3p21
Pascal p-value 0.672
Sherlock p-value 0.602
Fetal beta -0.757
DMG 1 (# studies)
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
简历:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance与精神分裂症nia keywords: schizophrenia,schizophrenic,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg07115110 3 46250024 CCR1 1.98E-5 -0.633 0.016 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs277655 chr3 100044586 CCR1 1230 0.14 trans
rs6551878 chr4 65690588 CCR1 1230 0.02 trans
rs3110966 chr5 38613942 CCR1 1230 0.11 trans
rs3734661 chr6 90651149 CCR1 1230 0.18 trans
rs17111364 chr10 97901813 CCR1 1230 0.07 trans
rs7069806 chr10 129628499 CCR1 1230 0.16 trans
rs11216730 chr11 117918701 CCR1 1230 0.07 trans
rs8072151 chr17 50228268 CCR1 1230 0 trans
rs17342483 chrX 102250155 CCR1 1230 0.09 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
CCL14 CC-1 | CC-3 | CKb1 | HCC-1 | HCC-3 | MCIF | NCC-2 | NCC2 | SCYA14 | SCYL2 | SY14 chemokine (C-C motif) ligand 14 - HPRD,BioGRID 11085751
CCL15 HCC-2 | HMRP-2B | LKN1 | Lkn-1 | MIP-1d | MIP-5 | NCC-3 | NCC3 | SCYA15 | SCYL3 | SY15 chemokine (C-C motif) ligand 15 - HPRD 9346309
CCL16 CKb12 | HCC-4 | ILINCK | LCC-1 | LEC | LMC | MGC117051 | Mtn-1 | NCC-4 | NCC4 | SCYA16 | SCYL4 chemokine (C-C motif) ligand 16 - HPRD,BioGRID 10910894|11470772
CCL23 CK-BETA-8 | CKb8 | Ckb-8 | Ckb-8-1 | MIP-3 | MIP3 | MPIF-1 | SCYA23 chemokine (C-C motif) ligand 23 - HPRD,BioGRID 9558365|9886417
|10660125
CCL3 G0S19-1 | LD78ALPHA | MIP-1-alpha | MIP1A | SCYA3 chemokine (C-C motif) ligand 3 - HPRD 10202040|10660125
CCL3L1 464.2 | D17S1718 | G0S19-2 | LD78 | LD78BETA | MGC104178 | MGC12815 | MGC182017 | MIP1AP | SCYA3L | SCYA3L1 chemokine (C-C motif) ligand 3-like 1 - HPRD,BioGRID 11449371
CCL5 D17S136E | MGC17164 | RANTES | SCYA5 | SISd | TCP228 chemokine (C-C motif) ligand 5 Reconstituted Complex BioGRID 11116158|11449371
CCL5 D17S136E | MGC17164 | RANTES | SCYA5 | SISd | TCP228 chemokine (C-C motif) ligand 5 - HPRD 9289016|11116158
|12270118|14637022
CCL7 FIC | MARC | MCP-3 | MCP3 | MGC138463 | MGC138465 | NC28 | SCYA6 | SCYA7 chemokine (C-C motif) ligand 7 - HPRD,BioGRID 8530354
CCL8 HC14 | MCP-2 | MCP2 | SCYA10 | SCYA8 chemokine (C-C motif) ligand 8 - HPRD,BioGRID 9115216
GNA14 - guanine nucleotide binding protein (G protein), alpha 14 - HPRD,BioGRID 8626727
PLP2 A4 | A4-LSB | MGC126187 proteolipid protein 2 (colonic epithelium-enriched) PLP2/A4 interacts with CCR1. This interaction was modelled on a demonstrated interaction between human PLP2/A4 and CCR1 from an unspecified species. BIND 15474493


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION 267 161 All SZGR 2.0 genes in this pathway
KEGG CHEMOKINE SIGNALING PATHWAY 190 128 All SZGR 2.0 genes in this pathway
BIOCARTA NKT PATHWAY 29 21 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME PEPTIDE LIGAND BINDING RECEPTORS 188 108 All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305 177 All SZGR 2.0 genes in this pathway
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES 57 27 All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805 368 All SZGR 2.0 genes in this pathway
REACTOME G ALPHA I SIGNALLING EVENTS 195 114 All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408 246 All SZGR 2.0 genes in this pathway
SCHUETZ BREAST CANCER DUCTAL INVASIVE UP 351 230 All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL DN 244 153 All SZGR 2.0 genes in this pathway
SMIRNOV CIRCULATING ENDOTHELIOCYTES IN CANCER UP 158 103 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 6HR DN 41 29 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 UP 380 236 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP 418 263 All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL DN 226 132 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443 294 All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF UP 215 137 All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO IONIZING RADIATION 149 101 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
BROWN MYELOID CELL DEVELOPMENT UP 165 100 All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475 313 All SZGR 2.0 genes in this pathway
DN ROETH叔目标 8 7 All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED UP 183 111 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 20HR UP 240 152 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS LATE PROGENITOR 544 307 All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS BY HNE AND H2O2 39 29 All SZGR 2.0 genes in this pathway
LIAN LIPA TARGETS 6M 74 47 All SZGR 2.0 genes in this pathway
LIAN LIPA TARGETS 3M 59 36 All SZGR 2.0 genes in this pathway
HENDRICKS SMARCA4 TARGETS DN 53 34 All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES DN 245 144 All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP 487 303 All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES UP 253 147 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022 619 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN 292 189 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281 179 All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS PTEN UP 181 112 All SZGR 2.0 genes in this pathway
GAURNIER PSMD4 TARGETS 73 55 All SZGR 2.0 genes in this pathway
奥巴马回应DARAPLADIB 29 20 All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA UP 259 185 All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE 35D UP 131 79 All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION D 68 44 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 DN 315 201 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP 418 282 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP 408 276 All SZGR 2.0 genes in this pathway
VANASSE BCL2 TARGETS DN 74 50 All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 5 33 24 All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER UP 288 168 All SZGR 2.0 genes in this pathway
SETLUR PROSTATE CANCER TMPRSS2 ERG FUSION DN 20 12 All SZGR 2.0 genes in this pathway
KUROZUMI RESPONSE TO ONCOCYTIC VIRUS 44 30 All SZGR 2.0 genes in this pathway
KUROZUMI RESPONSE TO ONCOCYTIC VIRUS AND CYCLIC RGD 21 15 All SZGR 2.0 genes in this pathway
SAKAI CHRONIC HEPATITIS VS LIVER CANCER UP 83 63 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857 456 All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN 374 217 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770 480 All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1 467 251 All SZGR 2.0 genes in this pathway
ALTEMEIER RESPONSE TO LPS WITH MECHANICAL VENTILATION 128 81 All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 6HR DN 114 69 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 All SZGR 2.0 genes in this pathway