Gene Page:ADH4
Summary?
| GeneID | 127 |
| Symbol | ADH4 |
| Synonyms | ADH-2|HEL-S-4 |
| Description | alcohol dehydrogenase 4 (class II), pi polypeptide |
| Reference | MIM:103740|HGNC:HGNC:252|Ensembl:ENSG00000198099|HPRD:00068|Vega:OTTHUMG00000161227 |
| Gene type | protein-coding |
| Map location | 4q22 |
| Pascal p-value | 0.975 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| PMID:cooccur | High-throughput literature-search | 系统搜索PubMed的共病的基因with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AC135178.1 | 0.64 | 0.54 |
| ZNF117 | 0.64 | 0.63 |
| TSSK3 | 0.63 | 0.47 |
| CCDC14 | 0.62 | 0.62 |
| ZNF334 | 0.61 | 0.62 |
| ZNF337 | 0.60 | 0.63 |
| DDX26B | 0.60 | 0.61 |
| ZNF266 | 0.60 | 0.56 |
| ZNF841 | 0.60 | 0.60 |
| ZNF528 | 0.59 | 0.62 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| LHPP | -0.44 | -0.55 |
| FBXO2 | -0.44 | -0.59 |
| UBTD1 | -0.43 | -0.56 |
| CA4 | -0.42 | -0.62 |
| AIFM3 | -0.42 | -0.58 |
| LDHD | -0.42 | -0.56 |
| ACYP2 | -0.42 | -0.54 |
| HLA-F | -0.41 | -0.57 |
| TSC22D4 | -0.41 | -0.58 |
| S100B | -0.41 | -0.58 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG GLYCOLYSIS GLUCONEOGENESIS | 62 | 41 | All SZGR 2.0 genes in this pathway |
| KEGG FATTY ACID METABOLISM | 42 | 29 | All SZGR 2.0 genes in this pathway |
| KEGG TYROSINE METABOLISM | 42 | 30 | All SZGR 2.0 genes in this pathway |
| KEGG RETINOL METABOLISM | 64 | 37 | All SZGR 2.0 genes in this pathway |
| KEGG METABOLISM OF XENOBIOTICS BY CYTOCHROME P450 | 70 | 44 | All SZGR 2.0 genes in this pathway |
| KEGG DRUG METABOLISM CYTOCHROME P450 | 72 | 47 | All SZGR 2.0 genes in this pathway |
| REACTOME BIOLOGICAL OXIDATIONS | 139 | 91 | All SZGR 2.0 genes in this pathway |
| REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | 70 | 50 | All SZGR 2.0 genes in this pathway |
| REACTOME ETHANOL OXIDATION | 10 | 9 | All SZGR 2.0 genes in this pathway |
| NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN | 634 | 384 | All SZGR 2.0 genes in this pathway |
| GINESTIER BREAST CANCER 20Q13 AMPLIFICATION UP | 119 | 66 | All SZGR 2.0 genes in this pathway |
| SHETH LIVER CANCER VS TXNIP LOSS PAM4 | 261 | 153 | All SZGR 2.0 genes in this pathway |
| BENPORATH CYCLING GENES | 648 | 385 | All SZGR 2.0 genes in this pathway |
| TARTE PLASMA CELL VS PLASMABLAST UP | 398 | 262 | All SZGR 2.0 genes in this pathway |
| UEDA PERIFERAL CLOCK | 169 | 111 | All SZGR 2.0 genes in this pathway |
| SANSOM APC TARGETS DN | 366 | 238 | All SZGR 2.0 genes in this pathway |
| HSIAO LIVER SPECIFIC GENES | 244 | 154 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER | 49 | 29 | All SZGR 2.0 genes in this pathway |
| ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN | 354 | 216 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER DN | 540 | 340 | All SZGR 2.0 genes in this pathway |
| CHIANG LIVER CANCER SUBCLASS PROLIFERATION DN | 179 | 97 | All SZGR 2.0 genes in this pathway |
| HOSHIDA LIVER CANCER SUBCLASS S3 | 266 | 180 | All SZGR 2.0 genes in this pathway |
| WHITFIELD CELL CYCLE G2 M | 216 | 124 | All SZGR 2.0 genes in this pathway |
| OHGUCHI LIVER HNF4A TARGETS DN | 149 | 85 | All SZGR 2.0 genes in this pathway |
| SERVITJA LIVER HNF1A TARGETS DN | 157 | 105 | All SZGR 2.0 genes in this pathway |
| FOSTER KDM1A TARGETS UP | 266 | 142 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | All SZGR 2.0 genes in this pathway |