SZGR2 - Beplay体育中心

Summary？

基因	1282
象征	COL4A1
Synonyms	BSVD \| Rator
Description	collagen type IV alpha 1
Reference	MIM：120130\|HGNC:HGNC:2202\|ENSEMBL：ENSG00000187498\|HPRD:00359\|Vega：Otthumg0000000017342
基因类型	蛋白质编码
Map location	13q34
Pascal p-value	0.757
Sherlock p-value	0.758
主持人	Myers' cis & trans

Gene in Data Sources

基因集名称	Method of gene set	Description	信息
CV:GWASdb	Genome-wide Association Studies	精神分裂症的GWASDB记录
CV:PGCnp	Genome-wide Association Study	GWAS

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	染色体	位置	主持人	Gene Entrez ID	QVALUE	EQTL类型
rs16846456	CHR3	172757337	COL4A1	1282	0.01	反式
rs4484667	CHR8	77440301	COL4A1	1282	0.06	反式
RS12254965	chr10	127297037	COL4A1	1282	0.07	反式
rs11856277	chr15	29722087	COL4A1	1282	0.18	反式
RS4780219	chr15	29726087	COL4A1	1282	0.16	反式

第二节。转录组注释

一般基因表达（GTEX）

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
CDAN1	0.84	0.83
Glis2	0.83	0.89
SEMA4B	0.82	0.84
ncan	0.81	0.85
RELA	0.81	0.83
SEPN1	0.81	0.86
PLXNB2	0.80	0.89
ARSD	0.80	0.79
HDAC6	0.80	0.81
ARHGEF10L	0.80	0.82

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
C5orf53	-0.63	-0.68
ACOT13	-0.60	-0.66
FAM162A	-0.57	-0.64
AF347015.27	-0.56	-0.65
AF347015.31	-0.55	-0.65
CA4	-0.54	-0.57
CA11	-0.54	-0.63
S100B	-0.54	-0.61
B2M	-0.54	-0.64
myl3	-0.53	-0.62

第三节。基因本体论注释

分子功能	去学期	证据	神经关键字	PubMed ID
去：0005488	binding	IEA		-
去：0005201	细胞外基质结构成分	IEA		-
Cellular component	去学期	证据	神经关键字	PubMed ID
去：0005576	细胞外区域	nas		14718574
去：0005581	collagen	IEA		-
去：0005604	basement membrane	IEA		-

Section IV. Protein-protein interaction annotation

互动者	别名b	官方全名b	实验	Source	PubMed ID
疼痛	ARACHE \| N-ACHE \| YT	acetylcholinesterase (Yt blood group)	-	HPRD	12524166
应用程序	AAA \|Abeta \|abpp \|AD1 \|appi \|ctfgamma \|CVAP \|PN2	淀粉样β（A4）前体蛋白	-	HPRD	9136074
CD93	C1QR1 \| C1qR(P) \| C1qRP \| CDw93 \| MXRA4 \| dJ737E23.1	CD93 molecule	-	HPRD	1377218
COL4A1	逮捕	collagen, type IV, alpha 1	-	HPRD,BioGRID	12011424
COL4A2	DKFZp686I14213 \| FLJ22259	collagen, type IV, alpha 2	-	HPRD,BioGRID	12011424
COL7A1	EBD1 \| EBDCT \| EBR1	胶原蛋白，第七型，alpha 1	-	HPRD,BioGRID	9169408
DCN	CSCD \|DSPG2 \|PG40 \|PGII \|PGS2 \|slrr1b	decorin	-	HPRD	10382266
DISC1	C1orf136 \|FLJ13381 \|FLJ21640 \|FLJ25311 \|FLJ41105 \|KIAA0457 \|SCZD9	精神分裂症中断1	Two-hybrid	Biogrid	12812986
FBLN2	-	fibulin 2	-	HPRD,BioGRID	7500359
FN1	CIG \| DKFZp686F10164 \| DKFZp686H0342 \| DKFZp686I1370 \| DKFZp686O13149 \| ED-B \| FINC \| FN \| FNZ \| GFND \| GFND2 \| LETS \| MSF	纤连蛋白1	-	HPRD	3997552
HABP2	FSAP \| HABP \| HGFAL \| PHBP	hyaluronan binding protein 2	-	HPRD,BioGRID	1724753
杂志	GMA \|s-mag \|SIGLEC-4A \|siglec4a	myelin associated glycoprotein	重构的复合物	Biogrid	2446864
MATN2	-	matrilin 2	-	HPRD	12180907
MMP9	CLG4B \| GELB \| MMP-9	基质金属肽酶9（明胶酶B，92KDA明胶酶，92KDA IV型胶原酶）	-	HPRD,BioGRID	9878537
nid1	nid	nidogen 1	重构的复合物	Biogrid	9733643
nid2	-	nidogen 2 (osteonidogen)	重构的复合物	Biogrid	9733643
OSM	MGC20461	oncostatin M	-	HPRD,BioGRID	11711546
SAA1	MGC111216 \|Pig4 \|saa \|TP53I4	血清淀粉样蛋白A1	-	HPRD	8995276
serpine2	GDN \| PI7 \| PN1 \| PNI	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2	-	HPRD,BioGRID	8006028
TGFBI	BIGH3 \| CDB1 \| CDG2 \| CDGG1 \| CSD \| CSD1 \| CSD2 \| CSD3 \| EBMD \| LCD1	反式forming growth factor, beta-induced, 68kDa	-	HPRD	11867580
THBS1	THBS \| TSP \| TSP1	thrombospondin 1	重构的复合物	Biogrid	3571333

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
kegg焦点粘附	201	138	All SZGR 2.0 genes in this pathway
KEGG ECM受体相互作用	84	53	All SZGR 2.0 genes in this pathway
癌症中的KEGG途径	328	259	All SZGR 2.0 genes in this pathway
KEGG SMALL CELL LUNG CANCER	84	67	All SZGR 2.0 genes in this pathway
BIOCARTA AMI PATHWAY	20	13	All SZGR 2.0 genes in this pathway
Biocarta ACE2途径	13	7	All SZGR 2.0 genes in this pathway
BIOCARTA INTRINSIC PATHWAY	23	15	All SZGR 2.0 genes in this pathway
Biocarta血小板途径	14	10	All SZGR 2.0 genes in this pathway
Biocarta VITCB途径	11	6	All SZGR 2.0 genes in this pathway
PID Integin1途径	66	44	All SZGR 2.0 genes in this pathway
PID Integin3途径	43	25	All SZGR 2.0 genes in this pathway
PID AVB3 INTEGRIN PATHWAY	75	53	All SZGR 2.0 genes in this pathway
PID Syndecan 1途径	46	29	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME EXTRACELLULAR MATRIX ORGANIZATION	87	42	All SZGR 2.0 genes in this pathway
Reactome胶原蛋白形成	58	31	All SZGR 2.0 genes in this pathway
Reactome整合素细胞表面相互作用	79	48	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF	122	93	All SZGR 2.0 genes in this pathway
Reactome Axon指导	251	188	All SZGR 2.0 genes in this pathway
Reactome NCAM1相互作用	39	27	All SZGR 2.0 genes in this pathway
Reactome NCAM信号传导，用于神经突的生长	64	49	All SZGR 2.0 genes in this pathway
中村肿瘤区周围与中央	285	181	All SZGR 2.0 genes in this pathway
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA UP	205	140	All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN	481	290	All SZGR 2.0 genes in this pathway
Onken Uveal黑色素瘤	783	507	All SZGR 2.0 genes in this pathway
SCHUETZ BREAST CANCER DUCTAL INVASIVE UP	351	230	All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA UP	294	178	All SZGR 2.0 genes in this pathway
TURASHVILI BREAST DUCTAL CARCINOMA VS DUCTAL NORMAL UP	44	25	All SZGR 2.0 genes in this pathway
TURASHVILI BREAST LOBULAR CARCINOMA VS LOBULAR NORMAL DN	74	42	All SZGR 2.0 genes in this pathway
周的炎症反应生活	485	293	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN	455	304	All SZGR 2.0 genes in this pathway
乳腺癌腔与间充质DN	460	312	All SZGR 2.0 genes in this pathway
罗伊伤口血管向上	50	30	All SZGR 2.0 genes in this pathway
Horiuchi WTAP靶向	306	188	All SZGR 2.0 genes in this pathway
vecchi胃癌先进与早期	175	120	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
多德鼻咽癌DN	1375	806	All SZGR 2.0 genes in this pathway
甲状腺癌的Rodrigues分化不佳的DN	805	505	All SZGR 2.0 genes in this pathway
LANDIS BREAST CANCER PROGRESSION DN	70	43	All SZGR 2.0 genes in this pathway
chiaradonna肿瘤转化CDC25 DN	153	100	All SZGR 2.0 genes in this pathway
BERENJENO ROCK SIGNALING NOT VIA RHOA DN	48	34	All SZGR 2.0 genes in this pathway
Vanharanta子宫肌瘤	45	26	All SZGR 2.0 genes in this pathway
LANDIS ERBB2 BREAST TUMORS 324 DN	149	93	All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER	747	453	All SZGR 2.0 genes in this pathway
Borlak肝癌EGF UP	57	41	All SZGR 2.0 genes in this pathway
OXFORD RALA AND RALB TARGETS DN	9	5	All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 2 DN	51	42	All SZGR 2.0 genes in this pathway
Khetchoumian Trim24靶向	47	38	All SZGR 2.0 genes in this pathway
Buytaert光动力疗法应力DN	637	377	All SZGR 2.0 genes in this pathway
WU细胞迁移	184	114	All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION UP	69	55	All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 480 HELA	164	118	All SZGR 2.0 genes in this pathway
Rozanov MMP14目标子集	33	20	All SZGR 2.0 genes in this pathway
Rozanov MMP14靶向	266	171	All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP	398	262	All SZGR 2.0 genes in this pathway
UEDA PERIFERAL CHICK	169	111	All SZGR 2.0 genes in this pathway
切斯勒大脑最高遗传差异	37	21	All SZGR 2.0 genes in this pathway
费尔南德斯（Fernandez）由迈克（Myc）约束	182	116	All SZGR 2.0 genes in this pathway
甜蜜的克拉斯靶向	84	51	All SZGR 2.0 genes in this pathway
李肝癌电抗	60	42	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS	882	572	All SZGR 2.0 genes in this pathway
马纳洛缺氧	207	145	All SZGR 2.0 genes in this pathway
Lee Liver Cancer Dena Up	60	40	All SZGR 2.0 genes in this pathway
Flechner活检肾脏移植OK vs捐助者	555	346	All SZGR 2.0 genes in this pathway
CROMER METASTASIS UP	79	46	All SZGR 2.0 genes in this pathway
Iglesias E2F目标	151	103	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
MODY HIPPOCAMPUS NEONATAL	35	25	All SZGR 2.0 genes in this pathway
Yamazaki TCEB3靶向	175	116	All SZGR 2.0 genes in this pathway
伊万诺娃造血干细胞	254	164	All SZGR 2.0 genes in this pathway
伯顿成生成2	72	52	All SZGR 2.0 genes in this pathway
tseng irs1靶向DN	135	88	All SZGR 2.0 genes in this pathway
阿尔茨海默氏症疾病初期DN	165	106	All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION NEOCORTEX DN	88	58	All SZGR 2.0 genes in this pathway
葡萄病毒感染DN的Debiasi凋亡DN	287	208	All SZGR 2.0 genes in this pathway
Bacolod抗烷基化剂DN	60	45	All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP	566	371	All SZGR 2.0 genes in this pathway
由喀斯特IWANAGA致癌PTEN DN	353	226	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP	973	570	All SZGR 2.0 genes in this pathway
阿塞维多肝肿瘤与正常的相邻组织向上	863	514	All SZGR 2.0 genes in this pathway
ZHENG GLIOBLASTOMA PLASTICITY DN	58	39	All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP	285	167	All SZGR 2.0 genes in this pathway
Cromer肿瘤发生	63	36	All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO RADIATION THERAPY	32	20	All SZGR 2.0 genes in this pathway
GU PDEF TARGETS UP	71	49	All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP	107	67	All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK	1210	725	All SZGR 2.0 genes in this pathway
MILI假足趋化性DN	457	302	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN	668	419	All SZGR 2.0 genes in this pathway
Croonquist NRA与基质刺激DN	99	65	All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SURVIVAL UP	73	49	All SZGR 2.0 genes in this pathway
Nakayama FGF2目标	29	17	All SZGR 2.0 genes in this pathway
Hoshida肝癌亚类S1	237	159	All SZGR 2.0 genes in this pathway
由MYC约束	1103	714	All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE	721	492	All SZGR 2.0 genes in this pathway
YAO对孕酮簇的时间反应16	79	47	All SZGR 2.0 genes in this pathway
lu eszh2靶向DN	414	237	All SZGR 2.0 genes in this pathway
康AR目标	17	10	All SZGR 2.0 genes in this pathway
Pilon KLF1靶向	504	321	All SZGR 2.0 genes in this pathway
Bruins通过TP53组B响应UVC响应	549	316	All SZGR 2.0 genes in this pathway
棕熊UVC响应迟到	1137	655	All SZGR 2.0 genes in this pathway
Kim Glis2靶向	84	61	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D	882	506	All SZGR 2.0 genes in this pathway
Delacroix Rar Bound ES	462	273	All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL UP	489	314	All SZGR 2.0 genes in this pathway
LIM MAMMARY LUMINAL MATURE DN	99	74	All SZGR 2.0 genes in this pathway
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF	516	308	All SZGR 2.0 genes in this pathway
Naba胶原蛋白	44	26	All SZGR 2.0 genes in this pathway
NABA CORE MATRISOME	275	148	All SZGR 2.0 genes in this pathway
NABA地下室膜	40	22	All SZGR 2.0 genes in this pathway
NABA MATRISOME	1028	559	All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族	Target position			miRNA ID	mirna seq
mirna家族	UTR开始	UTR结束	匹配方法	miRNA ID	mirna seq
let-7/98	88	94	1A	hsa-let-7a^brain	ugagguaguaguauauaguu
				hsa-let-7b^brain	ugagguaguagguuguguguguu
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	ugagguaggagguuauauagu
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				hsa-miR-98^brain	ugagguaaguuguauuguu
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	ugagguaguugugugugugcugu
mir-124.1	119	125	M8	HSA-MIR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	118	125	1A，M8	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	118	125	1A，M8	HSA-MIR-124^brain	UAAGGCACGCGGUGAAUGCC
mir-205	174	180	1A	hsa-miR-205	UCCUUCAUUCCACCGGAGUCUG
miR-29	308	314	1A	HSA-MIR-29A^SZ	UAGCACCAUCUGAAAUCGGUU
				HSA-MIR-29B^SZ	UAGCACCAUUUGAAAUCAGUGUU
				HSA-MIR-29C^SZ	uagcaccauuugaaaucggu
				HSA-MIR-29A^SZ	UAGCACCAUCUGAAAUCGGUU
				HSA-MIR-29B^SZ	UAGCACCAUUUGAAAUCAGUGUU
				HSA-MIR-29C^SZ	uagcaccauuugaaaucggu
miR-381	1292	1298	1A	HSA-MIR-381	uauacaagggcaagcucucugu
mir-410	655	661	1A	hsa-miR-410	aauauaacacagauggcugu

SZ：在精神分裂症患者的脑皮质中差异表达的miRNA与使用微阵列进行对照样品进行比较。点击hereto see the list of SZ related miRNAs.
大脑：基于miRNA微阵列表达研究在大脑中表达的miRNA。点击here查看与大脑相关的miRNA列表。

Gene Page:COL4A1