SZGR2 - Beplay体育中心

Summary？

基因	1284
象征	COL4A2
Synonyms	ICH \| POREN2
Description	胶原型IValpha 2
Reference	MIM:120090\|HGNC:HGNC:2203\|Ensembl:ENSG00000134871\|HPRD:00355\|Vega：Otthumg0000000017344
基因类型	蛋白质编码
Map location	13q34
Pascal p-value	0.963
Sherlock p-value	0.843
胎儿β	0.652
主持人	Putamen basal ganglia Myers' cis & trans 元

Gene in Data Sources

基因集名称	Method of gene set	Description
简历：Gwascat	Genome-wide Association Studies	该数据集包括与精神分裂症相关的560个SNP。总共将486个基因映射到50kb内的这些SNP。
CV:GWASdb	Genome-wide Association Studies	精神分裂症的GWASDB记录
CV:PGCnp	Genome-wide Association Study	GWAS

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	染色体	位置	主持人	Gene Entrez ID	pvalue	QVALUE	TSS距离	EQTL类型
RS16846456	CHR3	172757337	COL4A2	1284		0.02		反式
RS17007781	CHR4	124977313	COL4A2	1284		9.519E-4		反式
rs1028198	CHR4	124977733	COL4A2	1284		0.05		反式
RS1492754	CHR4	125421168	COL4A2	1284		0.15		反式
RS1492753	CHR4	125421324	COL4A2	1284		0.15		反式
rs4425392	CHR4	133569611	COL4A2	1284		0.05		反式
RS7906863	chr10	71176334	COL4A2	1284		0.04		反式
RS7078328	chr10	124029258	COL4A2	1284		0.04		反式
RS10510107	chr10	124029470	COL4A2	1284		0.03		反式
rs4317918	chr10	124065869	COL4A2	1284		0.04		反式
rs10887122	chr10	124071344	COL4A2	1284		0.04		反式
rs2175465	chr13	31797640	COL4A2	1284		0.1		反式
RS5806894	13	111942142	COL4A2	ENSG00000134871.13	1.685E-6	0.05	983983	gtex_brain_putamen_basal

第二节。转录组注释

一般基因表达（GTEX）

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
IGF2	0.92	0.86
Col1a1	0.91	0.77
ITIH2	0.89	0.80
NID2	0.88	0.39
COL3A1	0.88	0.57
ALX4	0.88	0.49
OSR1	0.88	0.66
SLC6A4	0.84	0.47
Col1a2	0.84	0.72
NID1	0.84	0.41

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
LHPP	-0.29	0.18
MRPL41	-0.27	-0.01
ACOT13	-0.27	0.08
C5orf53	-0.27	0.05
皮尔	-0.26	0.02
AF347015.33	-0.26	-0.01
HEPN1	-0.26	0.13
HLA-C	-0.26	0.14
MT-CO2	-0.26	-0.03
AF347015.31	-0.26	-0.00

第三节。基因本体论注释

分子功能	去学期	证据	神经关键字	PubMed ID
去：0005488	binding	IEA		-
去：0005201	细胞外基质结构成分	TAS		8317999
生物过程	去学期	证据	神经关键字	PubMed ID
GO：0016525	血管生成的阴性调节	IDA		10625665
GO:0030198	extracellular matrix organization	nas		8317999
Cellular component	去学期	证据	神经关键字	PubMed ID
去：0005576	细胞外区域	IEA		-
去：0005581	collagen	IEA		-
去：0005587	胶原型IV	TAS		2846280\|3345760

Section IV. Protein-protein interaction annotation

互动者	别名b	官方全名b	实验	Source	PubMed ID
应用程序	AAA \|Abeta \|abpp \|AD1 \|appi \|ctfgamma \|CVAP \|PN2	淀粉样β（A4）前体蛋白	-	HPRD	9136074
BGN	DSPG1 \| PG-S1 \| PGI \| SLRR1A	biglycan	-	HPRD	11259413
CD93	C1QR1 \| C1qR(P) \| C1qRP \| CDw93 \| MXRA4 \| dJ737E23.1	CD93 molecule	-	HPRD	1377218
COL4A1	逮捕	collagen, type IV, alpha 1	-	HPRD,BioGRID	12011424
COL4A2	DKFZp686I14213 \| FLJ22259	collagen, type IV, alpha 2	-	HPRD,BioGRID	12011424
DCN	CSCD \|DSPG2 \|PG40 \|PGII \|PGS2 \|slrr1b	decorin	-	HPRD	10382266
FBLN2	-	fibulin 2	-	HPRD,BioGRID	7500359
FN1	CIG \| DKFZp686F10164 \| DKFZp686H0342 \| DKFZp686I1370 \| DKFZp686O13149 \| ED-B \| FINC \| FN \| FNZ \| GFND \| GFND2 \| LETS \| MSF	纤连蛋白1	-	HPRD	3997552
HABP2	FSAP \| HABP \| HGFAL \| PHBP	hyaluronan binding protein 2	in vivo	Biogrid	1724753
MATN2	-	matrilin 2	-	HPRD	12180907
MMP9	CLG4B \| GELB \| MMP-9	基质金属肽酶9（明胶酶B，92KDA明胶酶，92KDA IV型胶原酶）	-	HPRD,BioGRID	9878537
OSM	MGC20461	oncostatin M	-	HPRD,BioGRID	11711546
SAA1	MGC111216 \|Pig4 \|saa \|TP53I4	血清淀粉样蛋白A1	-	HPRD	8995276
serpine2	GDN \|PI7 \|PN1 \|PNI	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2	-	HPRD,BioGRID	8006028
TGFBI	BIGH3 \| CDB1 \| CDG2 \| CDGG1 \| CSD \| CSD1 \| CSD2 \| CSD3 \| EBMD \| LCD1	反式forming growth factor, beta-induced, 68kDa	-	HPRD	11867580

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
kegg焦点粘附	201	138	All SZGR 2.0 genes in this pathway
KEGG ECM受体相互作用	84	53	All SZGR 2.0 genes in this pathway
癌症中的KEGG途径	328	259	All SZGR 2.0 genes in this pathway
KEGG SMALL CELL LUNG CANCER	84	67	All SZGR 2.0 genes in this pathway
BIOCARTA AMI PATHWAY	20	13	All SZGR 2.0 genes in this pathway
Biocarta ACE2途径	13	7	All SZGR 2.0 genes in this pathway
BIOCARTA INTRINSIC PATHWAY	23	15	All SZGR 2.0 genes in this pathway
Biocarta血小板途径	14	10	All SZGR 2.0 genes in this pathway
Biocarta VITCB途径	11	6	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME EXTRACELLULAR MATRIX ORGANIZATION	87	42	All SZGR 2.0 genes in this pathway
Reactome胶原蛋白形成	58	31	All SZGR 2.0 genes in this pathway
Reactome整合素细胞表面相互作用	79	48	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF	122	93	All SZGR 2.0 genes in this pathway
Reactome Axon指导	251	188	All SZGR 2.0 genes in this pathway
Reactome NCAM1相互作用	39	27	All SZGR 2.0 genes in this pathway
Reactome NCAM信号传导，用于神经突的生长	64	49	All SZGR 2.0 genes in this pathway
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA UP	205	140	All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN	481	290	All SZGR 2.0 genes in this pathway
Schuetz乳腺癌导管侵入性	351	230	All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA UP	294	178	All SZGR 2.0 genes in this pathway
TURASHVILI BREAST LOBULAR CARCINOMA VS LOBULAR NORMAL DN	74	42	All SZGR 2.0 genes in this pathway
VMYB vs CMYB DN的LIU目标	43	30	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN	455	304	All SZGR 2.0 genes in this pathway
乳腺癌腔与间充质DN	460	312	All SZGR 2.0 genes in this pathway
DITTMER PTHLH TARGETS UP	112	68	All SZGR 2.0 genes in this pathway
多德鼻咽癌DN	1375	806	All SZGR 2.0 genes in this pathway
甲状腺癌的Rodrigues分化不佳的DN	805	505	All SZGR 2.0 genes in this pathway
PROVENZANI METASTASIS DN	136	94	All SZGR 2.0 genes in this pathway
chiaradonna肿瘤转化Kras DN	142	95	All SZGR 2.0 genes in this pathway
chiaradonna肿瘤转化CDC25 DN	153	100	All SZGR 2.0 genes in this pathway
BERENJENO ROCK SIGNALING NOT VIA RHOA DN	48	34	All SZGR 2.0 genes in this pathway
Lindgren膀胱癌簇1 DN	378	231	All SZGR 2.0 genes in this pathway
Vanharanta子宫肌瘤	45	26	All SZGR 2.0 genes in this pathway
Wang Barretts食道和食道癌	26	12	All SZGR 2.0 genes in this pathway
林格伦膀胱癌高复发	49	31	All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN	712	443	All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER	747	453	All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 2 DN	51	42	All SZGR 2.0 genes in this pathway
瓦特自动甲状腺腺瘤	73	47	All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO IONIZING RADIATION	149	101	All SZGR 2.0 genes in this pathway
Khetchoumian Trim24靶向	47	38	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 UP	209	139	All SZGR 2.0 genes in this pathway
通过ELK3和HIF1A DN的缺氧总缺氧	103	71	All SZGR 2.0 genes in this pathway
Nuytten Nipp1靶向	769	437	All SZGR 2.0 genes in this pathway
Buytaert光动力疗法应力DN	637	377	All SZGR 2.0 genes in this pathway
洛佩兹MBD目标	957	597	All SZGR 2.0 genes in this pathway
魏MIR34A TARGETS	148	97	All SZGR 2.0 genes in this pathway
WU细胞迁移	184	114	All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION UP	69	55	All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 480 HELA	164	118	All SZGR 2.0 genes in this pathway
Rozanov MMP14目标子集	33	20	All SZGR 2.0 genes in this pathway
Rozanov MMP14靶向	266	171	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER ACOX1 UP	64	40	All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER METASTASIS DN	121	65	All SZGR 2.0 genes in this pathway
费尔南德斯（Fernandez）由迈克（Myc）约束	182	116	All SZGR 2.0 genes in this pathway
甜蜜的克拉斯靶向	84	51	All SZGR 2.0 genes in this pathway
李肝癌电抗	60	42	All SZGR 2.0 genes in this pathway
马纳洛缺氧	207	145	All SZGR 2.0 genes in this pathway
Lee Liver Cancer Dena Up	60	40	All SZGR 2.0 genes in this pathway
Yamazaki TCEB3靶向	175	116	All SZGR 2.0 genes in this pathway
MARIADASON REGULATED BY HISTONE ACETYLATION DN	54	30	All SZGR 2.0 genes in this pathway
tseng irs1靶向DN	135	88	All SZGR 2.0 genes in this pathway
伯顿成生成4	48	32	All SZGR 2.0 genes in this pathway
葡萄病毒感染DN的Debiasi凋亡DN	287	208	All SZGR 2.0 genes in this pathway
伊万诺娃造血细胞和祖细胞	681	420	All SZGR 2.0 genes in this pathway
Tseng脂肪势DN	46	28	All SZGR 2.0 genes in this pathway
URS ADIPOCYTE DIFFERENTIATION DN	30	20	All SZGR 2.0 genes in this pathway
MARCHINI TRABECTEDIN RESISTANCE DN	49	34	All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP	566	371	All SZGR 2.0 genes in this pathway
Krige对Tosedostat 6小时DN的响应	911	527	All SZGR 2.0 genes in this pathway
Krige对Tosedostat 24小时DN的反应	1011	592	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP	973	570	All SZGR 2.0 genes in this pathway
骨骼DN中的Smid乳腺癌复发	315	197	All SZGR 2.0 genes in this pathway
SMID乳腺癌腔B DN	564	326	All SZGR 2.0 genes in this pathway
Smid乳腺癌基础	648	398	All SZGR 2.0 genes in this pathway
西方肾上腺皮质肿瘤了	294	199	All SZGR 2.0 genes in this pathway
Mirlet7a3 DN的Brueckner目标	78	49	All SZGR 2.0 genes in this pathway
Qi Plasmacytoma dn	100	63	All SZGR 2.0 genes in this pathway
Cromer肿瘤发生	63	36	All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS UP	165	118	All SZGR 2.0 genes in this pathway
HELLEBREKERS SILENCED DURING TUMOR ANGIOGENESIS	80	56	All SZGR 2.0 genes in this pathway
GU PDEF TARGETS UP	71	49	All SZGR 2.0 genes in this pathway
公园APL发病机理DN	50	35	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN	668	419	All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2	277	172	All SZGR 2.0 genes in this pathway
Hoshida肝癌亚类S1	237	159	All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER POOR PROGNOSIS	55	30	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL SCP2 QTL TRANS	25	13	All SZGR 2.0 genes in this pathway
由MYC约束	1103	714	All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE	721	492	All SZGR 2.0 genes in this pathway
YAO对孕酮簇的时间反应16	79	47	All SZGR 2.0 genes in this pathway
康AR目标	17	10	All SZGR 2.0 genes in this pathway
Bruins通过TP53组B响应UVC响应	549	316	All SZGR 2.0 genes in this pathway
棕熊UVC响应迟到	1137	655	All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4	227	149	All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL UP	489	314	All SZGR 2.0 genes in this pathway
LIM MAMMARY LUMINAL MATURE DN	99	74	All SZGR 2.0 genes in this pathway
Naba胶原蛋白	44	26	All SZGR 2.0 genes in this pathway
NABA CORE MATRISOME	275	148	All SZGR 2.0 genes in this pathway
NABA地下室膜	40	22	All SZGR 2.0 genes in this pathway
NABA MATRISOME	1028	559	All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族	Target position			miRNA ID	mirna seq
mirna家族	UTR开始	UTR结束	匹配方法	miRNA ID	mirna seq
let-7/98	49	55	1A	hsa-let-7a^brain	ugagguaguaguauauaguu
				hsa-let-7b^brain	ugagguaguagguuguguguguu
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	ugagguaggagguuauauagu
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				hsa-miR-98^brain	ugagguaaguuguauuguu
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	ugagguaguugugugugugcugu
miR-29	28	34	M8	HSA-MIR-29A^SZ	UAGCACCAUCUGAAAUCGGUU
				HSA-MIR-29B^SZ	UAGCACCAUUUGAAAUCAGUGUU
				HSA-MIR-29C^SZ	uagcaccauuugaaaucggu
mir-9	107	113	M8	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA

SZ：在精神分裂症患者的脑皮质中差异表达的miRNA与使用微阵列进行对照样品进行比较。点击hereto see the list of SZ related miRNAs.
大脑：基于miRNA微阵列表达研究在大脑中表达的miRNA。点击here查看与大脑相关的miRNA列表。

Gene Page:COL4A2