Gene Page:COL7A1

Summary?
GeneID 1294
Symbol COL7A1
Synonyms EBD1|EBDCT|EBR1|NDNC8
Description collagen type VII alpha 1
Reference MIM:120120|HGNC:HGNC:2214|Ensembl:ENSG00000114270|HPRD:00358|Vega:OTTHUMG00000133541
Gene type protein-coding
Map location 3p21.1
Pascal p-value 0.014
Sherlock p-value 0.334
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs16829545 chr2 151977407 COL7A1 1294 6.985E-7 trans
rs3845734 chr2 171125572 COL7A1 1294 0 trans
rs7584986 chr2 184111432 COL7A1 1294 7.934E-5 trans
rs17762315 chr5 76807576 COL7A1 1294 0.11 trans
rs16955618 chr15 29937543 COL7A1 1294 5.804E-13 trans
rs1041786 chr21 22617710 COL7A1 1294 0.01 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconceptionweeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SDK2 0.80 0.82
DNAH10 0.78 0.76
MACF1 0.74 0.78
ICA1L 0.73 0.77
NAV2 0.72 0.82
ASXL3 0.71 0.75
ZNF70 0.71 0.72
ADAMTS9 0.71 0.75
MDGA1 0.71 0.79
TET2 0.71 0.76
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
HSD17B14 -0.48 -0.61
ACOT13 -0.47 -0.55
AF347015.31 -0.47 -0.66
TSC22D4 -0.47 -0.60
S100B -0.46 -0.63
RAMP1 -0.46 -0.60
MT-CO2 -0.46 -0.65
DCXR -0.46 -0.59
AF347015.27 -0.46 -0.62
BDH2 -0.46 -0.59

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PID INTEGRIN1 PATHWAY 66 44 All SZGR 2.0 genes in this pathway
PID AVB3 INTEGRIN PATHWAY 75 53 All SZGR 2.0 genes in this pathway
PID SYNDECAN 1 PATHWAY 46 29 All SZGR 2.0 genes in this pathway
REACTOME EXTRACELLULAR MATRIX ORGANIZATION 87 42 All SZGR 2.0 genes in this pathway
REACTOME COLLAGEN FORMATION 58 31 All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN 481 290 All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL UP 133 78 All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY UP 430 232 All SZGR 2.0 genes in this pathway
SMIRNOV CIRCULATING ENDOTHELIOCYTES IN CANCER UP 158 103 All SZGR 2.0 genes in this pathway
JAEGER METASTASIS DN 258 141 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION DN 329 219 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722 443 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508 354 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 DN 229 142 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 4 5WK UP 271 175 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL TGFB1 TARGETS UP 169 127 All SZGR 2.0 genes in this pathway
HU ANGIOGENESIS UP 21 16 All SZGR 2.0 genes in this pathway
HUMMERICH SKIN CANCER PROGRESSION UP 88 58 All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747 453 All SZGR 2.0 genes in this pathway
DAIRKEE TERT TARGETS UP 380 213 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648 385 All SZGR 2.0 genes in this pathway
CERVERA SDHB TARGETS 2 114 76 All SZGR 2.0 genes in this pathway
SWEET KRAS TARGETS UP 84 51 All SZGR 2.0 genes in this pathway
KANG IMMORTALIZED BY TERT UP 89 61 All SZGR 2.0 genes in this pathway
NGUYEN NOTCH1 TARGETS DN 86 67 All SZGR 2.0 genes in this pathway
URS ADIPOCYTE DIFFERENTIATION UP 74 51 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
TSENG IRS1 TARGETS UP 113 71 All SZGR 2.0 genes in this pathway
NIELSEN LEIOMYOSARCOMA UP 18 10 All SZGR 2.0 genes in this pathway
MAHAJAN RESPONSE TO IL1A UP 81 52 All SZGR 2.0 genes in this pathway
TSENG ADIPOGENIC POTENTIAL UP 30 19 All SZGR 2.0 genes in this pathway
LEE METASTASIS AND ALTERNATIVE SPLICING UP 74 51 All SZGR 2.0 genes in this pathway
MOOTHA PGC 420 269 All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G6 UP 65 43 All SZGR 2.0 genes in this pathway
MIKKELSEN IPS ICP WITH H3K4ME3 AND H327ME3 126 83 All SZGR 2.0 genes in this pathway
DORN ADENOVIRUS INFECTION 12HR DN 33 25 All SZGR 2.0 genes in this pathway
DORN ADENOVIRUS INFECTION 24HR DN 43 32 All SZGR 2.0 genes in this pathway
DORN ADENOVIRUS INFECTION 32HR DN 39 28 All SZGR 2.0 genes in this pathway
DORN ADENOVIRUS INFECTION 48HR DN 40 29 All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 718 401 All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE S 162 86 All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT 572 352 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549 316 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745 475 All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824 528 All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 AND SATB1 UP 87 52 All SZGR 2.0 genes in this pathway
JUBAN TARGETS OF SPI1 AND FLI1 UP 115 73 All SZGR 2.0 genes in this pathway
KOHOUTEK CCNT1 TARGETS 50 26 All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA VIA KDM3A 53 34 All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 PARTIAL 160 106 All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN 308 187 All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL UP 489 314 All SZGR 2.0 genes in this pathway
NABA胶原蛋白 44 26 All SZGR 2.0 genes in this pathway
NABA CORE MATRISOME 275 148 All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028 559 All SZGR 2.0 genes in this pathway