Gene Page:COMP

Summary?
GeneID 1311
Symbol COMP
Synonyms EDM1|EPD1|MED|PSACH|THBS5
Description cartilage oligomeric matrix protein
Reference MIM:600310|HGNC:HGNC:2227|Ensembl:ENSG00000105664|HPRD:02632|Vega:OTTHUMG00000169318
Gene type protein-coding
Map location 19p13.1
Pascal p-value 0.331
DMG 1 (# studies)
eGene Cerebellum
迈尔斯的独联体& trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccur High-throughput literature-search 系统搜索PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg09980058 19 18898325 COMP 3.38E-4 -0.406 0.041 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs3761082 chr19 19249726 COMP 1311 0.18 cis
rs4653163 chr1 36627444 COMP 1311 0.04 trans
rs12092846 chr1 59940646 COMP 1311 0 trans
rs13447530 chr1 91983798 COMP 1311 0.01 trans
rs6687849 chr1 175904808 COMP 1311 1.41E-5 trans
rs2481653 chr1 176044120 COMP 1311 0 trans
rs2502827 chr1 176044216 COMP 1311 9.982E-8 trans
rs10913839 chr1 179593165 COMP 1311 0.09 trans
rs3008613 chr1 222795768 COMP 1311 0.15 trans
rs882011 chr2 22711668 COMP 1311 9.828E-4 trans
rs17028363 chr2 41913161 COMP 1311 0 trans
rs16829545 chr2 151977407 COMP 1311 4.03E-16 trans
rs16841750 chr2 158288461 COMP 1311 3.43E-5 trans
rs16863816 chr2 177292762 COMP 1311 0.03 trans
rs7584986 chr2 184111432 COMP 1311 0.03 trans
rs10183246 chr2 237187882 COMP 1311 3.137E-6 trans
rs10195546 chr2 237187933 COMP 1311 1.114E-4 trans
rs2322831 chr3 4799093 COMP 1311 0.03 trans
rs4685815 chr3 4799947 COMP 1311 0.11 trans
rs9810143 chr3 5060209 COMP 1311 3.716E-9 trans
rs6797307 chr3 8601563 COMP 1311 4.634E-6 trans
rs6807632 chr3 111395567 COMP 1311 0 trans
rs917937 chr3 137411335 COMP 1311 0.06 trans
rs6773248 chr3 174790333 COMP 1311 0.01 trans
rs6797728 chr3 174790417 COMP 1311 0.01 trans
rs5030115 chr3 186457331 COMP 1311 0.08 trans
rs1996119 chr3 197531387 COMP 1311 4.925E-4 trans
rs16868907 chr4 19933369 COMP 1311 0.14 trans
rs4575988 chr4 19984925 COMP 1311 0.09 trans
rs12642340 chr4 35390674 COMP 1311 0.13 trans
rs662007 chr4 125253160 COMP 1311 0.02 trans
rs1608464 chr4 125318297 COMP 1311 0.16 trans
rs17008119 chr4 125321425 COMP 1311 6.259E-4 trans
rs7692715 chr4 125335209 COMP 1311 9.863E-5 trans
rs6821203 chr4 189475342 COMP 1311 0.02 trans
rs10474151 chr5 84286402 COMP 1311 0.01 trans
rs13360496 0 COMP 1311 0.01 trans
rs16890367 chr6 38078448 COMP 1311 1.077E-5 trans
rs12706918 chr7 80266147 COMP 1311 0.01 trans
rs2299269 chr7 95619376 COMP 1311 0.03 trans
rs2166120 chr7 153120003 COMP 1311 0.1 trans
rs6996695 chr8 77540580 COMP 1311 1.49E-5 trans
rs3118341 chr9 25185518 COMP 1311 0.08 trans
rs9406868 chr9 25223372 COMP 1311 0.1 trans
rs17263352 chr9 124811572 COMP 1311 0.17 trans
rs2287296 chr9 132395244 COMP 1311 0.03 trans
rs11005888 chr10 59421572 COMP 1311 0.14 trans
rs17124813 chr10 110347464 COMP 1311 0.07 trans
rs11215990 chr11 116407582 COMP 1311 0.17 trans
rs7972699 chr12 105155290 COMP 1311 2.714E-6 trans
rs7488439 chr12 105155814 COMP 1311 1.253E-7 trans
rs17036489 chr12 105292283 COMP 1311 1.501E-7 trans
rs890460 chr12 119644855 COMP 1311 0.07 trans
rs11060407 chr12 130017919 COMP 1311 0.17 trans
rs11060408 chr12 130018281 COMP 1311 0.15 trans
rs457696 chr13 32581313 COMP 1311 1.431E-5 trans
rs9566986 chr13 32595026 COMP 1311 7.987E-4 trans
rs1530404 chr13 64207519 COMP 1311 0.07 trans
rs17289777 chr13 64223062 COMP 1311 0.07 trans
rs7337531 chr13 109611085 COMP 1311 0.11 trans
rs177369 chr14 73760441 COMP 1311 0 trans
rs1629937 chr14 77059671 COMP 1311 0.04 trans
rs17104720 chr14 77127308 COMP 1311 0.01 trans
rs8009751 chr14 83313138 COMP 1311 0.06 trans
rs16955618 chr15 29937543 COMP 1311 2.098E-25 trans
rs2045264 chr15 94793620 COMP 1311 0.2 trans
rs1420984 chr16 51408733 COMP 1311 0.01 trans
rs16968252 chr17 31692447 COMP 1311 0.15 trans
rs8068272 chr17 49952680 COMP 1311 0.17 trans
rs17820517 chr17 53980462 COMP 1311 0.01 trans
rs17758736 chr17 54035819 COMP 1311 0.02 trans
rs17823633 chr17 68851458 COMP 1311 2.524E-4 trans
rs755768 chr17 75023387 COMP 1311 0.02 trans
rs11873184 chr18 1584081 COMP 1311 0.06 trans
rs17681878 chr18 34767223 COMP 1311 0.14 trans
rs17071138 chr18 61143907 COMP 1311 0.1 trans
rs6032295 chr20 44178138 COMP 1311 0.02 trans
rs6019060 chr20 46965832 COMP 1311 0.01 trans
rs749043 chr20 46995700 COMP 1311 9.253E-6 trans
rs1041786 chr21 22617710 COMP 1311 0.01 trans
rs7278206 chr21 28171971 COMP 1311 0.18 trans
rs5992807 chr22 18210821 COMP 1311 0.07 trans
rs7288523 chr22 50082517 COMP 1311 0.15 trans
rs16990575 chrX 32691327 COMP 1311 3.93E-4 trans
rs16993189 chrX 144666166 COMP 1311 0 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG TGF BETA SIGNALING PATHWAY 86 64 All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION 201 138 All SZGR 2.0 genes in this pathway
KEGG ECM RECEPTOR INTERACTION 84 53 All SZGR 2.0 genes in this pathway
SCHUETZ BREAST CANCER DUCTAL INVASIVE UP 351 230 All SZGR 2.0 genes in this pathway
TURASHVILI BREAST LOBULAR CARCINOMA VS DUCTAL NORMAL UP 69 38 All SZGR 2.0 genes in this pathway
TURASHVILI BREAST LOBULAR CARCINOMA VS LOBULAR NORMAL DN 74 42 All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443 294 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142 669 All SZGR 2.0 genes in this pathway
KIM MYCN AMPLIFICATION TARGETS UP 92 64 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
ROPERO HDAC2 TARGETS 114 71 All SZGR 2.0 genes in this pathway
RICKMAN HEAD AND NECK CANCER B 48 22 All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062 725 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652 441 All SZGR 2.0 genes in this pathway
ASTON MAJOR DEPRESSIVE DISORDER UP 49 36 All SZGR 2.0 genes in this pathway
TRAYNOR RETT SYNDROM DN 19 14 All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE UP 249 170 All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP 487 303 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 UP 428 266 All SZGR 2.0 genes in this pathway
LY AGING MIDDLE UP 14 11 All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP 439 257 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN LUNG DN 37 22 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701 446 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425 298 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME2 AND H3K27ME3 59 35 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 491 319 All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435 318 All SZGR 2.0 genes in this pathway
LY AGING OLD UP 7 5 All SZGR 2.0 genes in this pathway
PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 DN 157 106 All SZGR 2.0 genes in this pathway
ANASTASSIOU CANCER MESENCHYMAL TRANSITION SIGNATURE 64 40 All SZGR 2.0 genes in this pathway
WARTERS RESPONSE TO IR SKIN 83 44 All SZGR 2.0 genes in this pathway
NABA ECM GLYCOPROTEINS 196 99 All SZGR 2.0 genes in this pathway
NABA CORE MATRISOME 275 148 All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028 559 All SZGR 2.0 genes in this pathway