基因页面:DCBLD2

Summary?
GeneID 131566
Symbol DCBLD2
Synonyms CLCP1|ESDN
Description discoidin, CUB and LCCL domain containing 2
Reference MIM:608698|HGNC:HGNC:24627|Ensembl:ENSG00000057019|HPRD:10567|Vega:OTTHUMG00000151985
Gene type protein-coding
Map location 3q12.1|3
Pascal p-value 0.367
Sherlock p-value 0.038
Fetal beta 0.914
DMG 2 (# studies)
eGene Anterior cingulate cortex BA24
Cerebellar Hemisphere
Cerebellum
Frontal Cortex BA9
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Nishioka_2013 Genome-wide DNA methylation analysis The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 2
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.04359
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.04047

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg07435592 3 98619796 DCBLD2 3.072E-4 0.395 0.04 DMG:Wockner_2014
cg07435592 3 98619796 DCBLD2 -0.025 0.26 DMG:Nishioka_2013

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs16955618 chr15 29937543 DCBLD2 131566 0.14 trans
rs1082411 3 98757172 DCBLD2 ENSG00000057019.11 1.61461E-6 0.04 -136639 gtex_brain_ba24

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005515 protein binding NAS 11447234
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007155 cell adhesion IEA -
GO:0042060 wound healing IDA 11447234
GO:0042060 wound healing ISS -
GO:0030522 intracellular receptor-mediated signaling pathway NAS 11447234
GO:0030308 negative regulation of cell growth IDA 11447234
GO:0030308 negative regulation of cell growth ISS -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0016020 membrane IEA -
GO:0009986 cell surface IDA 11447234
GO:0009986 cell surface ISS -
GO:0005887 integral to plasma membrane IDA 11447234
GO:0005887 integral to plasma membrane ISS -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
CHARAFE BREAST CANCER LUMINAL VS BASAL DN 455 304 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN 460 312 All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS UP 456 228 All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP 501 327 All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP DN 199 124 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722 443 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA DN 77 52 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2A DN 141 84 All SZGR 2.0 genes in this pathway
KAN RESPONSE TO ARSENIC TRIOXIDE 123 80 All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423 265 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795 478 All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS UP 292 168 All SZGR 2.0 genes in this pathway
WU CELL MIGRATION 184 114 All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893 528 All SZGR 2.0 genes in this pathway
SUNG METASTASIS STROMA UP 110 70 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 DN 169 102 All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP 412 249 All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN 408 274 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP 390 242 All SZGR 2.0 genes in this pathway
HENDRICKS SMARCA4 TARGETS UP 56 35 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY DN 145 88 All SZGR 2.0 genes in this pathway
BILD SRC ONCOGENIC SIGNATURE 62 38 All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566 371 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911 527 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011 592 All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE UP 156 92 All SZGR 2.0 genes in this pathway
HUANG DASATINIB RESISTANCE UP 81 53 All SZGR 2.0 genes in this pathway
CHANG CORE SERUM RESPONSE UP 212 128 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN 668 419 All SZGR 2.0 genes in this pathway
KOBAYASHI EGFR SIGNALING 24HR DN 251 151 All SZGR 2.0 genes in this pathway
WINNEPENNINCKX MELANOMA METASTASIS UP 162 86 All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM AND NORMAL AGING UP 93 62 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA MESENCHYMAL 216 130 All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT 572 352 All SZGR 2.0 genes in this pathway
HOELZEL NF1 TARGETS UP 139 93 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504 321 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137 655 All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS DN 229 135 All SZGR 2.0 genes in this pathway
AZARE NEOPLASTIC TRANSFORMATION BY STAT3 UP 121 70 All SZGR 2.0 genes in this pathway
PURBEY CTBP1没有SATB1的目标 344 215 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658 397 All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL UP 289 184 All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL UP 489 314 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-101 228 234 1A hsa-miR-101 UACAGUACUGUGAUAACUGAAG
hsa-miR-101 UACAGUACUGUGAUAACUGAAG
hsa-miR-101 UACAGUACUGUGAUAACUGAAG
miR-103/107 313 320 1A,m8 hsa-miR-103brain AGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brain AGCAGCAUUGUACAGGGCUAUCA
miR-130/301 2716 2722 m8 hsa-miR-130abrain CAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301 CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrain CAGUGCAAUGAUGAAAGGGCAU
hsa - mir - 454 - 3 - p UAGUGCAAUAUUGCUUAUAGGGUUU
miR-139 3245 3251 m8 hsa-miR-139brain UCUACAGUGCACGUGUCU
miR-144 228 234 1A hsa-miR-144 UACAGUAUAGAUGAUGUACUAG
hsa-miR-144 UACAGUAUAGAUGAUGUACUAG
miR-15/16/195/424/497 7 13 m8 hsa-miR-15abrain UAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrain UAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZ UAGCAGCACAGAAAUAUUGGC
hsa-miR-424 CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497 CAGCAGCACACUGUGGUUUGU
miR-17-5p/20/93.mr/106/519.d 2718 2724 m8 hsa-miR-17-5p CAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519d CAAAGUGCCUCCCUUUAGAGUGU
miR-181 3218 3224 1A hsa-miR-181abrain AACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZ AACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrain AACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrain AACAUUCAUUGUUGUCGGUGGGUU
hsa-miR-181abrain AACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZ AACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrain AACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrain AACAUUCAUUGUUGUCGGUGGGUU
miR-19 2715 2721 m8 hsa-miR-19a UGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19b UGUGCAAAUCCAUGCAAAACUGA
miR-218 34 40 m8 hsa-miR-218brain UUGUGCUUGAUCUAACCAUGU
miR-219 2373 2380 1A,m8 hsa-miR-219brain UGAUUGUCCAAACGCAAUUCU
miR-23 2394 2401 1A,m8 hsa-miR-23abrain AUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrain AUCACAUUGCCAGGGAUUACC
miR-24 2241 2247 m8 hsa-miR-24SZ UGGCUCAGUUCAGCAGGAACAG
miR-26 2994 3000 1A hsa-miR-26abrain UUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZ UUCAAGUAAUUCAGGAUAGGUU
miR-31 150 157 1A,m8 hsa-miR-31 AGGCAAGAUGCUGGCAUAGCUG
miR-320 1959 1965 1A hsa-miR-320 AAAAGCUGGGUUGAGAGGGCGAA
miR-381 3263 3269 1A hsa-miR-381 UAUACAAGGGCAAGCUCUCUGU
miR-494 2704 2711 1A,m8 hsa-miR-494brain UGAAACAUACACGGGAAACCUCUU
miR-542-3p 95 101 m8 hsa-miR-542-3p UGUGACAGAUUGAUAACUGAAA
miR-9 1998 2004 1A hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA