Gene Page:MAP3K8

Summary?
GeneID 1326
Symbol MAP3K8
Synonyms AURA2|COT|EST|ESTF|MEKK8|TPL2|Tpl-2|c-COT
Description mitogen-activated protein kinase kinase kinase 8
Reference MIM:191195|HGNC:HGNC:6860|Ensembl:ENSG00000107968|HPRD:01863|Vega:OTTHUMG00000017889
Gene type protein-coding
Map location 10p11.23
Pascal p-value 0.88
Fetal beta 0.216
DMG 1 (# studies)

Gene in Data Sources
基因集名称 Method of gene set Description Info
CV:PGCnp 基因族群me-wide Association Study GWAS
DMG:Jaffe_2016 基因族群me-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0333

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg04081651 10 30722660 MAP3K8 3.2E-10 0。016 7.03E-7 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0000287 magnesium ion binding IEA -
GO:0005515 protein binding IEA -
GO:0005515 protein binding 新闻学会 15169888
GO:0005524 ATP binding IEA -
GO:0004672 protein kinase activity IEA -
GO:0004674 protein serine/threonine kinase activity TAS 8226782
GO:0004709 MAP kinase kinase kinase activity IEA -
GO:0016740 transferase activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006468 protein amino acid phosphorylation IEA -
GO:0006468 protein amino acid phosphorylation TAS 2072910
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005829 cytosol TAS 8226782
GO:0005737 cytoplasm IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
AKT1 AKT | MGC99656 | PKB | PKB-ALPHA | PRKBA | RAC | RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 - HPRD,BioGRID 12138205
CHUK IKBKA | IKK-alpha | IKK1 | IKKA | NFKBIKA | TCF16 conserved helix-loop-helix ubiquitous kinase - HPRD,BioGRID 10072079
KSR2 FLJ25965 kinase suppressor of ras 2 Affinity Capture-Western BioGRID 12975377
MAP2K1 MAPKK1 | MEK1 | MKK1 | PRKMK1 mitogen-activated protein kinase kinase 1 Biochemical Activity BioGRID 8631303
MAP2K4 JNKK | JNKK1 | MAPKK4 | MEK4 | MKK4 | PRKMK4 | SEK1 | SERK1 mitogen-activated protein kinase kinase 4 - HPRD,BioGRID 8631303
MAP3K14 FTDCR1B | HS | HSNIK | NIK mitogen-activated protein kinase kinase kinase 14 - HPRD,BioGRID 10072079
NFKB1 DKFZp686C01211 | EBP-1 | KBF1 | MGC54151 | NF-kappa-B | NFKB-p105 | NFKB-p50 | p105 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 - HPRD,BioGRID 9950430
NFKB2 LYT-10 | LYT10 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) Affinity Capture-MS BioGRID 14743216
REL C-Rel v-rel reticuloendotheliosis viral oncogene homolog (avian) Affinity Capture-MS BioGRID 14743216
RELA MGC131774 | NFKB3 | p65 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Affinity Capture-MS BioGRID 14743216
TNIP2 ABIN-2 | ABIN2 | FLIP1 | KLIP | MGC4289 TNFAIP3 interacting protein 2 - HPRD,BioGRID 14743216|15169888
TRAF2 MGC:45012 | TRAP | TRAP3 TNF receptor-associated factor 2 - HPRD,BioGRID 11932422


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG MAPK SIGNALING PATHWAY 267 205 All SZGR 2.0 genes in this pathway
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY 102 88 All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY 108 89 All SZGR 2.0 genes in this pathway
BIOCARTA MAPK PATHWAY 87 68 All SZGR 2.0 genes in this pathway
ST ERK1 ERK2 MAPK PATHWAY 32 25 All SZGR 2.0 genes in this pathway
PID TCR PATHWAY 66 51 All SZGR 2.0 genes in this pathway
PID CD8 TCR PATHWAY 53 42 All SZGR 2.0 genes in this pathway
PID NFAT 3PATHWAY 54 47 All SZGR 2.0 genes in this pathway
PID TCR RAS PATHWAY 14 14 All SZGR 2.0 genes in this pathway
PID TCR JNK PATHWAY 14 11 All SZGR 2.0 genes in this pathway
REACTOME CD28 CO STIMULATION 32 26 All SZGR 2.0 genes in this pathway
REACTOME COSTIMULATION BY THE CD28 FAMILY 63 48 All SZGR 2.0 genes in this pathway
REACTOME CD28 DEPENDENT PI3K AKT SIGNALING 22 18 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS 107 86 All SZGR 2.0 genes in this pathway
REACTOME IL1 SIGNALING 39 30 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539 350 All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270 204 All SZGR 2.0 genes in this pathway
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA DN 136 86 All SZGR 2.0 genes in this pathway
WILCOX RESPONSE TO PROGESTERONE UP 152 90 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463 290 All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY UP 78 41 All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS UP 456 228 All SZGR 2.0 genes in this pathway
ODONNELL TARGETS OF MYC AND TFRC UP 83 50 All SZGR 2.0 genes in this pathway
NAGASHIMA NRG1 SIGNALING UP 176 123 All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP DN 199 124 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508 354 All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS F UP 185 119 All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 2 127 92 All SZGR 2.0 genes in this pathway
RASHI NFKB1 TARGETS 19 18 All SZGR 2.0 genes in this pathway
SCHEIDEREIT IKK INTERACTING PROTEINS 58 45 All SZGR 2.0 genes in this pathway
SHI SPARC TARGETS DN 13 8 All SZGR 2.0 genes in this pathway
THEODOROU乳腺肿瘤发生 31 24 All SZGR 2.0 genes in this pathway
AMIT SERUM RESPONSE 60 MCF10A 57 42 All SZGR 2.0 genes in this pathway
SUNG METASTASIS STROMA UP 110 70 All SZGR 2.0 genes in this pathway
MORI MATURE B LYMPHOCYTE UP 90 62 All SZGR 2.0 genes in this pathway
BROCKE APOPTOSIS REVERSED BY IL6 144 98 All SZGR 2.0 genes in this pathway
SWEET KRAS TARGETS UP 84 51 All SZGR 2.0 genes in this pathway
BASSO CD40 SIGNALING UP 101 76 All SZGR 2.0 genes in this pathway
YIH RESPONSE TO ARSENITE C4 18 12 All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP 487 303 All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS UP 280 183 All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P4 100 62 All SZGR 2.0 genes in this pathway
GAVIN IL2 RESPONSIVE FOXP3 TARGETS UP 19 12 All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3 491 310 All SZGR 2.0 genes in this pathway
ZHENG FOXP3 TARGETS UP 26 16 All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN 409 268 All SZGR 2.0 genes in this pathway
KONDO EZH2 TARGETS 245 148 All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION UP 282 183 All SZGR 2.0 genes in this pathway
ENGELMANN CANCER PROGENITORS UP 48 31 All SZGR 2.0 genes in this pathway
GRADE METASTASIS DN 45 31 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425 298 All SZGR 2.0 genes in this pathway
BREDEMEYER RAG SIGNALING VIA ATM NOT VIA NFKB UP 49 32 All SZGR 2.0 genes in this pathway
FIRESTEIN PROLIFERATION 175 125 All SZGR 2.0 genes in this pathway
CHANG CORE SERUM RESPONSE UP 212 128 All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210 725 All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS CTNNB1 UP 176 110 All SZGR 2.0 genes in this pathway
UZONYI RESPONSE TO LEUKOTRIENE AND THROMBIN 37 26 All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS UP 221 135 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 1 68 50 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 2HR UP 39 30 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN 505 328 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898 516 All SZGR 2.0 genes in this pathway
ALTEMEIER RESPONSE TO LPS WITH MECHANICAL VENTILATION 128 81 All SZGR 2.0 genes in this pathway
ZWANG CLASS 3 TRANSIENTLY INDUCED BY EGF 222 159 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-140 680 687 1A,m8 hsa - mir - 140brain AGUGGUUUUACCCUAUGGUAG
miR-146 199 205 1A hsa-miR-146a UGAGAACUGAAUUCCAUGGGUU
hsa-miR-146bbrain UGAGAACUGAAUUCCAUAGGCU
miR-17-5p/20/93.mr/106/519.d 286 292 m8 hsa-miR-17-5p CAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519d CAAAGUGCCUCCCUUUAGAGUGU
miR-299-3p 683 689 1A hsa-miR-299-3p UAUGUGGGAUGGUAAACCGCUU
miR-299-5p 678 685 1A,m8 hsa-miR-299-5p UGGUUUACCGUCCCACAUACAU
miR-370 567 573 m8 hsa-miR-370brain GCCUGCUGGGGUGGAACCUGG
miR-539 205 212 1A,m8 hsa-miR-539 GGAGAAAUUAUCCUUGGUGUGU