Gene Page:ADORA2A

Summary?
GeneID 135
Symbol ADORA2A
Synonyms A2aR|ADORA2|RDC8
Description adenosine A2a receptor
Reference MIM:102776|HGNC:HGNC:263|Ensembl:ENSG00000128271|Ensembl:ENSG00000258555|HPRD:00043|Vega:OTTHUMG00000150761
Gene type protein-coding
Map location 22q11.23
Pascal p-value 0.434
Sherlock p-value 0.973
Fetal beta 0.578
eGene Myers' cis & trans
Support GPCR SIGNALLING

Gene in Data Sources
Gene set name Method of gene set Description Info
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I Genome scan meta-analysis Psr: 0.031
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 4
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.1128

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs596985 chr1 64277034 ADORA2A 135 0.15 trans
rs16838771 chr1 157511227 ADORA2A 135 2.199E-5 trans
rs17575539 chr2 62766126 ADORA2A 135 0.13 trans
rs17019687 chr2 80972176 ADORA2A 135 0.14 trans
rs1881496 chr2 233372354 ADORA2A 135 0.04 trans
rs6803351 chr3 17336986 ADORA2A 135 0.04 trans
rs11916205 chr3 17392363 ADORA2A 135 0.04 trans
rs17043486 chr3 17399005 ADORA2A 135 0.04 trans
rs17029249 chr3 17416384 ADORA2A 135 0.04 trans
rs17043623 chr3 17478890 ADORA2A 135 0.04 trans
rs11128830 chr3 17481727 ADORA2A 135 0.04 trans
rs17044097 chr3 17889750 ADORA2A 135 0.04 trans
rs17044102 chr3 17889838 ADORA2A 135 0.12 trans
rs4627772 0 ADORA2A 135 0.06 trans
rs17079580 chr3 47363841 ADORA2A 135 0.06 trans
rs12633404 chr3 80381837 ADORA2A 135 0.01 trans
rs12637719 chr3 85328350 ADORA2A 135 2.888E-4 trans
rs17647031 chr3 116102744 ADORA2A 135 0.18 trans
rs16864324 chr3 189106780 ADORA2A 135 0.2 trans
rs12651357 chr4 53029658 ADORA2A 135 0.18 trans
rs9996479 chr4 53029771 ADORA2A 135 0.18 trans
rs3025740 chr4 114163593 ADORA2A 135 0.02 trans
snp_a-4195294 0 ADORA2A 135 0.03 trans
rs16894524 chr5 65192799 ADORA2A 135 0.15 trans
rs17459137 chr5 114603454 ADORA2A 135 0.06 trans
rs3812061 chr5 126213763 ADORA2A 135 0.01 trans
rs12655258 chr5 126267350 ADORA2A 135 0.05 trans
rs12652390 chr5 126322101 ADORA2A 135 2.15E-4 trans
rs17165249 chr5 126395510 ADORA2A 135 0.12 trans
rs17165234 chr5 126403634 ADORA2A 135 3.703E-7 trans
rs12655006 chr5 126407601 ADORA2A 135 0.04 trans
rs12656879 chr5 126599075 ADORA2A 135 0.1 trans
rs3733727 chr5 134689299 ADORA2A 135 0.06 trans
rs2270172 chr6 30592413 ADORA2A 135 0.02 trans
rs1041915 chr6 130014252 ADORA2A 135 0.16 trans
rs9397728 chr6 150514248 ADORA2A 135 2.437E-4 trans
rs11987753 chr8 110166238 ADORA2A 135 0.04 trans
rs10963890 chr9 18977332 ADORA2A 135 0.07 trans
rs6479279 chr9 107476888 ADORA2A 135 0.16 trans
rs2066315 chr10 514137 ADORA2A 135 0.03 trans
rs10794751 chr10 1514218 ADORA2A 135 0.2 trans
rs1440195 chr11 116183393 ADORA2A 135 0.08 trans
rs11178166 chr12 70670585 ADORA2A 135 0.05 trans
rs2297479 chr12 125591249 ADORA2A 135 0.08 trans
rs9603093 chr13 37337849 ADORA2A 135 0.04 trans
rs854406 chr14 25204350 ADORA2A 135 0.11 trans
rs8008199 chr14 31002111 ADORA2A 135 0.1 trans
rs4981760 chr14 31002684 ADORA2A 135 0.02 trans
rs230349 chr14 31130389 ADORA2A 135 0.09 trans
rs230365 chr14 31139870 ADORA2A 135 0.16 trans
rs11628947 chr14 31161925 ADORA2A 135 0.16 trans
rs17104965 chr14 37145915 ADORA2A 135 0 trans
rs17105036 chr14 37154593 ADORA2A 135 0 trans
rs362341 chr14 73641457 ADORA2A 135 0.04 trans
rs4564513 chr15 57960009 ADORA2A 135 0.11 trans
rs8056861 chr16 56921039 ADORA2A 135 0 trans
rs443222 chr16 83889679 ADORA2A 135 0.01 trans
rs824575 chr16 83891459 ADORA2A 135 0.01 trans
rs1056626 chr17 4931552 ADORA2A 135 0.19 trans
rs355306 chr18 33105716 ADORA2A 135 0.01 trans
rs7504799 chr18 70057077 ADORA2A 135 0.19 trans
rs10405894 chr19 52631599 ADORA2A 135 0.12 trans
rs6102879 chr20 41138766 ADORA2A 135 0.18 trans
rs2835891 chr21 39056226 ADORA2A 135 0.01 trans
rs1883665 chrX 17650382 ADORA2A 135 4.912E-6 trans
rs7062071 chrX 17724830 ADORA2A 135 0.01 trans
rs12690023 chrX 50830077 ADORA2A 135 0.15 trans
rs7879274 chrX 145592957 ADORA2A 135 0.14 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0001609 adenosine receptor activity, G-protein coupled 国际能源机构 -
GO:0004872 receptor activity 国际能源机构 -
GO:0016519 gastric inhibitory peptide receptor activity NAS 8522976
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0007417 central nervous system development TAS Brain (GO term level: 6) 10945659
GO:0032230 positive regulation of synaptic transmission, GABAergic 国际能源机构 neuron, GABA, Synap, Neurotransmitter (GO term level: 10) -
GO:0001963 synaptic transmission, dopaminergic 国际能源机构 neuron, Synap, Neurotransmitter, dopamine (GO term level: 8) -
GO:0006836 neurotransmitter transport NAS neuron, Neurotransmitter (GO term level: 5) 8522976
GO:0001975 response to amphetamine 国际能源机构 -
GO:0001973 adenosine receptor signaling pathway 国际能源机构 -
GO:0007190 activation of adenylate cyclase activity EXP 16805430
GO:0007189 G-protein signaling, adenylate cyclase activating pathway 国际能源机构 -
去:0007188 G-protein signaling, coupled to cAMP nucleotide second messenger TAS 10899090
去:0007186 G-protein coupled receptor protein signaling pathway 国际能源机构 -
GO:0007169 跨膜受体蛋白酪氨酸kinase signaling pathway EXP 16939974
GO:0007267 cell-cell signaling TAS 7818494
GO:0006171 cAMP biosynthetic process TAS 10899090
GO:0006968 cellular defense response TAS 10051547
GO:0007165 signal transduction 国际能源机构 -
GO:0008015 blood circulation TAS 9262401
GO:0007626 locomotory behavior 国际能源机构 -
GO:0007600 sensory perception TAS 9262401
GO:0007596 blood coagulation TAS 10899090
GO:0006954 inflammatory response TAS 8360491
GO:0006915 apoptosis TAS 7818494
GO:0006909 phagocytosis TAS 8360491
GO:0042755 eating behavior 国际能源机构 -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005624 membrane fraction 国际能源机构 -
GO:0005624 membrane fraction TAS 10051547
GO:0016021 integral to membrane 国际能源机构 -
GO:0005886 plasma membrane TAS 8794889|10051547
GO:0005887 integral to plasma membrane TAS 8794889

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CALCIUM SIGNALING PATHWAY 178 134 All SZGR 2.0 genes in this pathway
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272 195 All SZGR 2.0 genes in this pathway
KEGG VASCULAR SMOOTH MUSCLE CONTRACTION 115 81 All SZGR 2.0 genes in this pathway
PID HIF2PATHWAY 34 29 All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF 217 167 All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 137 105 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305 177 All SZGR 2.0 genes in this pathway
REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS 16 8 All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805 368 All SZGR 2.0 genes in this pathway
REACTOME G ALPHA S SIGNALLING EVENTS 121 82 All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408 246 All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 5 147 89 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2B 392 251 All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS DN 411 249 All SZGR 2.0 genes in this pathway
ROZANOV MMP14 TARGETS UP 266 171 All SZGR 2.0 genes in this pathway
FAELT B CLL WITH VH REARRANGEMENTS UP 48 34 All SZGR 2.0 genes in this pathway
MCCLUNG DELTA FOSB TARGETS 8WK 47 38 All SZGR 2.0 genes in this pathway
MCCLUNG COCAINE REWARD 5D 79 62 All SZGR 2.0 genes in this pathway
ZHANG ANTIVIRAL RESPONSE TO RIBAVIRIN DN 51 32 All SZGR 2.0 genes in this pathway
SAFFORD T LYMPHOCYTE ANERGY 87 54 All SZGR 2.0 genes in this pathway
MAHAJAN RESPONSE TO IL1A UP 81 52 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022 619 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE UP 156 92 All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE DN 264 159 All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION B 53 36 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536 296 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435 318 All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS DN 213 127 All SZGR 2.0 genes in this pathway
CERIBELLI GENES INACTIVE AND BOUND BY NFY 45 27 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725 838 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-214 537 543 m8 hsa-miR-214brain ACAGCAGGCACAGACAGGCAG
miR-34b 786 792 m8 hsa-miR-34b UAGGCAGUGUCAUUAGCUGAUUG