Gene Page:CRABP1

Summary?
GeneID 1381
Symbol CRABP1
Synonyms CRABP|CRABP-I|CRABPI|RBP5
Description cellular retinoic acid binding protein 1
Reference MIM:180230|HGNC:HGNC:2338|Ensembl:ENSG00000166426|HPRD:07520|Vega:OTTHUMG00000143862
Gene type protein-coding
Map location 15q24
Pascal p-value 0.085
Sherlock p-value 0.004
Fetal beta -0.266
eGene Myers' cis & trans

Gene in Data Sources
基因集name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs17131472 chr1 91962966 CRABP1 1381 0.12 trans
rs17535450 chr2 39900012 CRABP1 1381 0.03 trans
rs11706314 chr3 45309716 CRABP1 1381 0 trans
rs11706394 chr3 45309907 CRABP1 1381 0.01 trans
rs2922180 chr3 125280472 CRABP1 1381 0 trans
rs2976809 chr3 125451738 CRABP1 1381 5.004E-4 trans
rs17090446 chr4 62255221 CRABP1 1381 0.15 trans
rs4241605 chr4 78161505 CRABP1 1381 0.19 trans
rs7668550 chr4 104384355 CRABP1 1381 0.02 trans
rs3796892 chr4 111404774 CRABP1 1381 0.09 trans
rs16894149 chr5 61013724 CRABP1 1381 0.02 trans
rs6449550 chr5 61034312 CRABP1 1381 0.01 trans
rs4489051 chr5 147954484 CRABP1 1381 0.02 trans
rs6874540 chr5 149911669 CRABP1 1381 0.15 trans
rs2273232 chr5 149912526 CRABP1 1381 0.15 trans
rs17056435 chr5 158453782 CRABP1 1381 0.02 trans
rs9313797 chr5 158465457 CRABP1 1381 0.01 trans
rs17056474 chr5 158468105 CRABP1 1381 0.01 trans
rs2294262 chr6 16108966 CRABP1 1381 0.11 trans
rs6455226 chr6 67930295 CRABP1 1381 0.19 trans
rs16868852 chr6 70980333 CRABP1 1381 0.2 trans
rs9387571 chr6 118600137 CRABP1 1381 0.08 trans
rs283063 chr6 118621313 CRABP1 1381 0.04 trans
rs9321275 chr6 131493217 CRABP1 1381 0.08 trans
rs2430483 chr7 104548631 CRABP1 1381 0.04 trans
rs2199402 chr8 9201002 CRABP1 1381 0.01 trans
rs7841407 chr8 9243427 CRABP1 1381 3.327E-4 trans
rs2410231 chr8 14954549 CRABP1 1381 0.18 trans
rs7029518 chr9 37782560 CRABP1 1381 0.11 trans
rs10521469 chr9 78884328 CRABP1 1381 0.13 trans
rs998410 chr9 117622673 CRABP1 1381 0.07 trans
rs9423711 chr10 2574802 CRABP1 1381 0.01 trans
rs748375 chr10 33440178 CRABP1 1381 0.14 trans
rs11820030 chr11 76133564 CRABP1 1381 0 trans
rs17134872 chr11 76139845 CRABP1 1381 1.674E-4 trans
rs10751255 0 CRABP1 1381 0.01 trans
rs11236774 chr11 76234952 CRABP1 1381 1.674E-4 trans
rs11067174 chr12 115011927 CRABP1 1381 0.08 trans
rs4349050 chr13 41958722 CRABP1 1381 0.19 trans
rs7982172 chr13 41969697 CRABP1 1381 0.16 trans
rs4942043 chr13 41978218 CRABP1 1381 0.13 trans
rs1750009 chr13 42657093 CRABP1 1381 0.02 trans
rs9596788 chr13 53924430 CRABP1 1381 0.04 trans
rs9529974 chr13 72821935 CRABP1 1381 3.842E-4 trans
rs17720221 chr13 75182377 CRABP1 1381 0.03 trans
rs17073665 chr13 81541961 CRABP1 1381 0.07 trans
rs11840833 chr13 94378306 CRABP1 1381 0.14 trans
rs10149864 chr14 86719683 CRABP1 1381 0.1 trans
rs2093759 chr14 97171024 CRABP1 1381 0.01 trans
rs17244419 chr14 97171074 CRABP1 1381 0 trans
rs7165622 chr15 93979910 CRABP1 1381 0.11 trans
rs17294918 chr16 52717122 CRABP1 1381 0.15 trans
rs11873703 chr18 61448702 CRABP1 1381 2.158E-5 trans
rs17191809 chr21 36444778 CRABP1 1381 0.03 trans
rs6000401 chr22 37149335 CRABP1 1381 0.16 trans
rs5991662 chrX 43335796 CRABP1 1381 0.19 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
FAM162A 0.82 0.83
ACYP2 0.81 0.80
TM2D1 0.78 0.75
NDUFB5 0.77 0.74
MOCS2 0.76 0.73
ACOT13 0.75 0.80
TMEM126B 0.75 0.75
CISD1 0.75 0.73
NDUFA4 0.75 0.77
NDUFA9 0.75 0.72
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
VAV2 -0.57 -0.56
KIAA1211 -0.57 -0.55
VASH1 -0.57 -0.57
C21orf30 -0.57 -0.60
NHSL1 -0.57 -0.64
KIAA1949 -0.57 -0.56
SH3BP2 -0.57 -0.66
GMIP -0.57 -0.47
ANO8 -0.56 -0.59
LSS -0.56 -0.59

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
LIU PROSTATE CANCER DN 481 290 All SZGR 2.0 genes in this pathway
LEE NEURAL CREST STEM CELL UP 146 99 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION DN 329 219 All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER DN 232 154 All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS CDC25 UP 58 39 All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS UP 126 72 All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION CDC25 UP 120 73 All SZGR 2.0 genes in this pathway
MARKEY RB1 CHRONIC LOF UP 115 78 All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN 228 137 All SZGR 2.0 genes in this pathway
TANAKA METHYLATED IN ESOPHAGEAL CARCINOMA 103 58 All SZGR 2.0 genes in this pathway
LA MEN1 TARGETS 24 15 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN 428 306 All SZGR 2.0 genes in this pathway
RICKMAN HEAD AND NECK CANCER A 100 63 All SZGR 2.0 genes in this pathway
BENPORATH ES 1 379 235 All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
BECKER TAMOXIFEN RESISTANCE UP 50 36 All SZGR 2.0 genes in this pathway
BHATTACHARYA EMBRYONIC STEM CELL 89 60 All SZGR 2.0 genes in this pathway
AFFAR YY1 TARGETS DN 234 137 All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY NO BLOOD DN 150 93 All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY DN 145 88 All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS DN 215 132 All SZGR 2.0 genes in this pathway
JACKSON DNMT1 TARGETS DN 25 21 All SZGR 2.0 genes in this pathway
BANDRES RESPONSE TO CARMUSTIN MGMT 48HR DN 161 105 All SZGR 2.0 genes in this pathway
CHEN ETV5 TARGETS TESTIS 23 14 All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566 371 All SZGR 2.0 genes in this pathway
KONDO PROSTATE CANCER HCP WITH H3K27ME3 97 72 All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE DN 258 160 All SZGR 2.0 genes in this pathway
乳腺癌萧述三腔的DN 564 326 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP 648 398 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 AND H3K27ME3 349 234 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME2 AND H3K27ME3 59 35 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S3 266 180 All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA1 DN 74 47 All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA2 UP 87 50 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 16 79 47 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857 456 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137 655 All SZGR 2.0 genes in this pathway
VANDESLUIS COMMD1 TARGETS GROUP 3 DN 39 21 All SZGR 2.0 genes in this pathway
FOSTER KDM1A TARGETS UP 266 142 All SZGR 2.0 genes in this pathway
BOSCO TH1 CYTOTOXIC MODULE 114 62 All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN 308 187 All SZGR 2.0 genes in this pathway
DURAND STROMA S UP 297 194 All SZGR 2.0 genes in this pathway