Gene Page:CREB1

Summary？
GeneID 1385
Symbol CREB1
Synonyms Creb | Creb-1
Description cAMP responsive element binding protein 1
Reference MIM：123810|HGNC:HGNC:2345|Ensembl:ENSG00000118260|HPRD:00442|Vega：Otthumg00000132936
基因类型 蛋白质编码
Map location 2Q34
Pascal p-value 3.592E-6
Sherlock p-value 0.153
胎儿β 1.69

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:PGCnp Genome-wide Association Study GWAS
PMID：cooccur High-throughput literature-search PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
GSMA_IIA Genome scan meta-analysis (All samples) PSR：0.00916
gsma_iie Genome scan meta-analysis (European-ancestry samples) Psr: 0.01016
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias 点击显示详细信息
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0239

Section I. Genetics and epigenetics annotation


第二节。转录组注释

一般基因表达（GTEX）

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
NDRG4 0.81 0.78
GPR123 0.81 0.82
SYNGR3 0.80 0.83
GPR61 0.79 0.77
C19orf28 0.78 0.79
ZDHHC14 0.78 0.77
SLC25A22 0.78 0.82
猪 0.77 0.78
PPAPDC3 0.77 0.80
clstn3 0.77 0.75
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RAB13 -0.41 -0.49
GTF3C6 -0.40 -0.39
NSBP1 -0.39 -0.44
ANP32B -0.39 -0.48
EIF5B -0.39 -0.45
RBMX2 -0.38 -0.39
C21orf57 -0.38 -0.37
GSTM2 -0.37 -0.38
CWF19L2 -0.36 -0.41
C9orf46 -0.36 -0.36

第三节。基因本体论注释

Molecular function 去学期 证据 神经关键字 PubMed ID
GO:0003700 transcription factor activity IEA -
GO:0003700 transcription factor activity TAS 10909971
GO:0003712 transcription cofactor activity TAS 8552098
GO:0043565 sequence-specific DNA binding IEA -
GO:0046983 protein dimerization activity IEA -
Biological process 去学期 证据 神经关键字 PubMed ID
GO:0006355 调节转录，DNA依赖性的调节 IEA -
GO:0006468 protein amino acid phosphorylation IDA 8798441
去:0007165 signal transduction TAS 2974179
GO:0044419 interspecies interaction between organisms IEA -
Cellular component 去学期 证据 神经关键字 PubMed ID
去：0005634 nucleus IEA -
去：0005634 nucleus TAS 10909971
去：0005654 nucleoplasm EXP 9687510|9770464|9829964

Section IV. Protein-protein interaction annotation

Interactors 别名b 官方全名b 实验 Source PubMed ID
ABL1 ABL |JTK7 |BCR/ABL |c-abl |P150 |V-ABL C-ABL癌基因1，受体酪氨酸激酶 重构的复合物 Biogrid 7565761
ATF1 EWS-ATF1 | FUS/ATF-1 | TREB36 activating transcription factor 1 - HPRD,BioGRID 1655749|8384217
ATM AT1 | ATA | ATC | ATD | ATDC | ATE | DKFZp781A0353 | MGC74674 | TEL1 | TELO1 ataxia telangiectasia mutated 亲和力捕获 - 韦斯特恩 Biogrid 15073328
BRCA1 Brcai |BRCC1 |虹膜|PSCP |RNF53 breast cancer 1, early onset Phenotypic Enhancement Biogrid 10945975
C14orf1 ERG28 | NET51 chromosome 14 open reading frame 1 Two-hybrid Biogrid 16169070
CAMK2A CAMKA |KIAA0968 钙/钙调蛋白依赖性蛋白激酶IIα 生化活动 Biogrid 8663317
CCND1 bcl1 |D11S287E |prad1 |U21B31 cyclin D1 CREB interacts with CRE. 绑定 15897899
CEBPB C/EBP-beta | CRP2 | IL6DBP | LAP | MGC32080 | NF-IL6 | TCF5 CCAAT/enhancer binding protein (C/EBP), beta - HPRD,BioGRID 12773552
CHD3 Mi-2a | Mi2-ALPHA | ZFH chromodomain helicase DNA binding protein 3 Two-hybrid Biogrid 16169070
克雷布 CBP | KAT3A | RSTS CREB binding protein CREB1（CREB）与CREBBP（CBP）相互作用。 绑定 16007092
克雷布 CBP | KAT3A | RSTS CREB binding protein CBP与CREB相互作用。 绑定 15454081
克雷布 CBP | KAT3A | RSTS CREB binding protein - HPRD,BioGRID 9413984
克莱姆 ICER | MGC111110 | MGC17881 | MGC41893 | hCREM-2 cAMP responsive element modulator - HPRD 7809053
CRTC1 FLJ14027 | KIAA0616 | MECT1 | TORC1 | WAMTP1 CREB regulated transcription coactivator 1 TORC1 interacts with CREB. 绑定 15454081
CYP19A1 ARO | ARO1 | CPV1 | CYAR | CYP19 | MGC104309 | P-450AROM cytochrome P450, family 19, subfamily A, polypeptide 1 CREB1 (CREB) interacts with the CYP19A1 (aromatase PII) promoter. 绑定 15688015
dyrk1a DYRK | DYRK1 | HP86 | MNB | MNBH 双特异性酪氨酸（Y） - 磷酸化调节激酶1a dyrk1ainteracts with and phosphorylates CREB. This interaction was modeled on a demonstrated interaction between human DYRK1A and CREB from rat. 绑定 15694837
EDF1 EDF-1 |MBF1 |MGC9058 endothelial differentiation-related factor 1 - HPRD,BioGRID 10567391
EP300 KAT3B | p300 E1A binding protein p300 亲和力捕获 - 韦斯特恩 Biogrid 10506141
FHL2 AAG11 |Dral |Slim3 four and a half LIM domains 2 亲和力捕获 - 韦斯特恩
Two-hybrid		 Biogrid 11046156
FHL3 MGC19547 |MGC23614 |MGC8696 |Slim2 four and a half LIM domains 3 亲和力捕获 - 韦斯特恩
Two-hybrid		 Biogrid 11046156
FHL5 ACT | FLJ33049 | KIAA0776 | RP3-393D12.2 | dJ393D12.2 four and a half LIM domains 5 - HPRD,BioGRID 11046156
FOSL1 联邦铁路局|FRA1 | fra-1 FOS-like antigen 1 CREB interacts with the region of the FRA-1 promoter containing the SRE and ATF sites. 绑定 15806162
Gli2 HPE9 | THP1 | THP2 gli-kruppel家庭成员gli2 - HPRD,BioGRID 10074179
GTF2F2 BTF4 | RAP30 | TF2F2 | TFIIF general transcription factor IIF, polypeptide 2, 30kDa - HPRD 8628277
HNF1B fjhn |hnf1beta |HNF2 |HPC11 |LF-B3 |LFB3 |Mody5 |TCF2 |VHNF1 HNF1 homeobox B Two-hybrid Biogrid 9671480
KAT5 ESA1 | HTATIP | HTATIP1 | PLIP | TIP | TIP60 | cPLA2 K（赖氨酸）乙酰转移酶5 - HPRD,BioGRID 10720489
KCNIP3 CSEN | DREAM | KCHIP3 | MGC18289 KV通道相互作用蛋白3，calsenilin - HPRD,BioGRID 12198160
MAPK14 CSBP1 |CSBP2 |CSPB1 |Exip |mxi2 |PRKM14 |PRKM15 |RK |SAPK2A |p38 | p38ALPHA 有丝分裂原激活的蛋白激酶14 - HPRD,BioGRID 11377386
NR3C1 GCCR |GCR |gr |grl nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) - HPRD,BioGRID 7621901|8449898
NR4A2 HZF-3 | NOT | NURR1 | RNR1 | TINUR 核受体亚科4，A组，成员2 CREB的未指定同工型与Nurr1启动子结合。 绑定 15961999
PDX1 GSF |IDX-1 |IPF1 |IUF1 |Mody4 |PDX-1 |STF-1 pancreatic and duodenal homeobox 1 - HPRD 7505393
Prkaca MGC102831 |MGC48865 |pkaca protein kinase, cAMP-dependent, catalytic, alpha 重构的复合物 Biogrid 11500364
RAB1A DKFZP564B163 |Rab1 |YPT1 RAB1A, member RAS oncogene family Two-hybrid Biogrid 16169070
RBBP4 NURF55 |RBAP48 retinoblastoma binding protein 4 Two-hybrid Biogrid 10866654
RECQL5 FLJ90603 |RECQ5 RecQ protein-like 5 Two-hybrid Biogrid 16169070
RPS6KA4 MSK2 |RSK-B ribosomal protein S6 kinase, 90kDa, polypeptide 4 - HPRD,BioGRID 9792677
RPS6KA5 MGC1911 | MSK1 | MSPK1 | RLPK ribosomal protein S6 kinase, 90kDa, polypeptide 5 生化活动
重构的复合物		 Biogrid 9687510|11500364
THRA AR7 | EAR7 | ERB-T-1 | ERBA | ERBA1 | MGC000261 | MGC43240 | NR1A1 | THRA1 | THRA2 | c-ERBA-1 thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian) - HPRD 12805224
TP53 FLJ92943 | LFS1 | TRP53 | p53 肿瘤蛋白p53 亲和力捕获 - 韦斯特恩
重构的复合物		 Biogrid 10848610
VIM FLJ36605 波形蛋白 Two-hybrid Biogrid 16169070
yy1 DELTA | INO80S | NF-E1 | UCRBP | YIN-YANG-1 yy1transcription factor yy1interacts with CREB. 绑定 7769693


Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
KEGG抗原处理和演示 89 65 All SZGR 2.0 genes in this pathway
KEGG MELANOGENESIS 102 80 All SZGR 2.0 genes in this pathway
KEGG加压素调节的水重吸收 44 30 All SZGR 2.0 genes in this pathway
KEGG HUNTINGTONS DISEASE 185 109 All SZGR 2.0 genes in this pathway
KEGG PROSTATE CANCER 89 75 All SZGR 2.0 genes in this pathway
Biocarta Cacam途径 16 11 All SZGR 2.0 genes in this pathway
Biocarta HCMV途径 17 16 All SZGR 2.0 genes in this pathway
Biocarta HIF途径 15 12 All SZGR 2.0 genes in this pathway
BIOCARTA MAPK PATHWAY 87 68 All SZGR 2.0 genes in this pathway
BIOCARTA ARENRF2 PATHWAY 13 9 All SZGR 2.0 genes in this pathway
Biocarta P38MAPK途径 40 31 All SZGR 2.0 genes in this pathway
Biocarta Dream Pathway 14 13 All SZGR 2.0 genes in this pathway
Biocarta ERK5途径 18 15 All SZGR 2.0 genes in this pathway
BIOCARTA GPCR PATHWAY 37 31 All SZGR 2.0 genes in this pathway
Biocarta Creb途径 27 25 All SZGR 2.0 genes in this pathway
Biocarta Carm1途径 13 11 All SZGR 2.0 genes in this pathway
ST DIFFERENTIATION PATHWAY IN PC12 CELLS 45 35 All SZGR 2.0 genes in this pathway
ST ERK1 ERK2 MAPK途径 32 25 All SZGR 2.0 genes in this pathway
SIG PIP3在心脏肌周期中发出信号 67 54 All SZGR 2.0 genes in this pathway
st g alpha的路径 16 11 All SZGR 2.0 genes in this pathway
ST P38 MAPK PATHWAY 37 28 All SZGR 2.0 genes in this pathway
ST GRANULE CELL SURVIVAL PATHWAY 27 23 All SZGR 2.0 genes in this pathway
PID SMAD2 3核途径 82 63 All SZGR 2.0 genes in this pathway
PID LPA4 PATHWAY 15 10 All SZGR 2.0 genes in this pathway
PID幼稚园 45 32 All SZGR 2.0 genes in this pathway
PID RET PATHWAY 39 29 All SZGR 2.0 genes in this pathway
PID LKB1 PATHWAY 47 37 All SZGR 2.0 genes in this pathway
PID HNF3B途径 45 37 All SZGR 2.0 genes in this pathway
PID REG GR PATHWAY 82 60 All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY 105 78 All SZGR 2.0 genes in this pathway
PID ATF2 PATHWAY 59 43 All SZGR 2.0 genes in this pathway
PID AP1 PATHWAY 70 60 All SZGR 2.0 genes in this pathway
PID P38 MK2途径 21 19 All SZGR 2.0 genes in this pathway
PID AR NONGENOMIC PATHWAY 31 27 All SZGR 2.0 genes in this pathway
PID P38 ALPHA BETA DOWNSTREAM PATHWAY 38 29 All SZGR 2.0 genes in this pathway
PID MYC REPRESS PATHWAY 63 52 All SZGR 2.0 genes in this pathway
PID HIF1 TFPathway 66 52 All SZGR 2.0 genes in this pathway
PID MAPK TRK PATHWAY 34 31 All SZGR 2.0 genes in this pathway
PID PI3K PLC TRK途径 36 31 All SZGR 2.0 genes in this pathway
PID LYMPH ANGIOGENESIS PATHWAY 25 16 All SZGR 2.0 genes in this pathway
REACTOME标记LLING BY NGF 217 167 All SZGR 2.0 genes in this pathway
SCF套件的Reactome信号传导 78 59 All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396 292 All SZGR 2.0 genes in this pathway
REACTOME DAG AND IP3 SIGNALING 32 25 All SZGR 2.0 genes in this pathway
REACTOME TRIF MEDIATED TLR3 SIGNALING 74 54 All SZGR 2.0 genes in this pathway
REACTOME标记LING BY ERBB4 90 67 All SZGR 2.0 genes in this pathway
REACTOME标记LING BY ERBB2 101 78 All SZGR 2.0 genes in this pathway
EGFR在癌症中的反应组信号传导 109 80 All SZGR 2.0 genes in this pathway
REACTOME PI3K EVENTS IN ERBB4 SIGNALING 38 28 All SZGR 2.0 genes in this pathway
ERBB2信号中的Reactome PI3K事件 44 34 All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 97 66 All SZGR 2.0 genes in this pathway
REACTOME标记LING BY THE B CELL RECEPTOR BCR 126 90 All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 137 105 All SZGR 2.0 genes in this pathway
FGFR的Reactome信号传导IN DISEASE 127 88 All SZGR 2.0 genes in this pathway
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 205 136 All SZGR 2.0 genes in this pathway
Reactome核事件激酶和转录因子激活 24 20 All SZGR 2.0 genes in this pathway
REACTOME PI3K AKT ACTIVATION 38 29 All SZGR 2.0 genes in this pathway
REACTOME GAB1 SIGNALOSOME 38 29 All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 186 155 All SZGR 2.0 genes in this pathway
REACTOME神经系统 279 221 All SZGR 2.0 genes in this pathway
REACTOME标记LING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME OPIOID SIGNALLING 78 56 All SZGR 2.0 genes in this pathway
REACTOME CA DEPENDENT EVENTS 30 23 All SZGR 2.0 genes in this pathway
反应组神经递质受体结合和突触后细胞中的下游传播 137 110 All SZGR 2.0 genes in this pathway
REACTOME PLC BETA MEDIATED EVENTS 43 32 All SZGR 2.0 genes in this pathway
REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB 18 14 All SZGR 2.0 genes in this pathway
REACTOME标记LING BY PDGF 122 93 All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION 95 76 All SZGR 2.0 genes in this pathway
Reactome Axon指导 251 188 All SZGR 2.0 genes in this pathway
Reactome NCAM信号传导，用于神经突的生长 64 49 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 37 32 All SZGR 2.0 genes in this pathway
REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 27 23 All SZGR 2.0 genes in this pathway
反应组后NMDA受体激活事件 33 28 All SZGR 2.0 genes in this pathway
Reactome Creb通过CAMKII的激活来磷酸化 15 14 All SZGR 2.0 genes in this pathway
Reactome Pi 3K级联 56 39 All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR 100 74 All SZGR 2.0 genes in this pathway
TLR级联反应组MAP激酶激活 50 37 All SZGR 2.0 genes in this pathway
Reactome磷脂酶C介导的级联 54 40 All SZGR 2.0 genes in this pathway
REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 30 24 All SZGR 2.0 genes in this pathway
REACTOME CIRCADIAN CLOCK 53 40 All SZGR 2.0 genes in this pathway
Reactome Traf6在TLR7 8或9激活上介导的NFKB和MAP激酶的诱导 77 57 All SZGR 2.0 genes in this pathway
REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE 72 53 All SZGR 2.0 genes in this pathway
Reactome myd88 mal级联反应于质膜发起 83 63 All SZGR 2.0 genes in this pathway
Reactome先天免疫系统 279 178 All SZGR 2.0 genes in this pathway
Reactome激活的TLR4信号传导 93 69 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
Reactome收费受体级联 118 84 All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539 350 All SZGR 2.0 genes in this pathway
Reactome Pip3激活Akt信号传导 29 20 All SZGR 2.0 genes in this pathway
FGFR的Reactome信号传导 112 80 All SZGR 2.0 genes in this pathway
Wang LMO4靶向 372 227 All SZGR 2.0 genes in this pathway
GINESTIER乳腺癌ZNF217放大 78 48 All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN 275 168 All SZGR 2.0 genes in this pathway
莱茵所有糖皮质激素治疗DN 362 238 All SZGR 2.0 genes in this pathway
Dittmer PTHLH靶向DN 73 51 All SZGR 2.0 genes in this pathway
UDayakumar Med1靶向 135 82 All SZGR 2.0 genes in this pathway
Tien肠益生菌24小时DN 214 133 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485 334 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
哈马凋亡通过Trail Up 584 356 All SZGR 2.0 genes in this pathway
Turjanski MAPK7目标 8 8 All SZGR 2.0 genes in this pathway
HAEGERSTRAND RESPONSE TO IMATINIB 9 5 All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 3 48 31 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN 483 336 All SZGR 2.0 genes in this pathway
Sheth肝癌与TXNIP损失PAM6 46 32 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS UP 344 180 All SZGR 2.0 genes in this pathway
Koyama Sema3b靶向 292 168 All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775 494 All SZGR 2.0 genes in this pathway
戈德拉斯体内平衡增殖 171 102 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555 346 All SZGR 2.0 genes in this pathway
Affar YY1靶向DN 234 137 All SZGR 2.0 genes in this pathway
HNE和TBH的Weigel氧化应激 60 42 All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS UP 198 132 All SZGR 2.0 genes in this pathway
Hedenfalk乳腺癌BRCA1与BRCA2 163 113 All SZGR 2.0 genes in this pathway
由FOXP3绑定的Marson刺激 1022 619 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
Hoshida肝癌生存DN 113 76 All SZGR 2.0 genes in this pathway
由MYC约束 1103 714 All SZGR 2.0 genes in this pathway
lu eszh2靶向DN 414 237 All SZGR 2.0 genes in this pathway
FEVR CTNNB1靶向DN 553 343 All SZGR 2.0 genes in this pathway
通过p38部分的phong TNF响应 160 106 All SZGR 2.0 genes in this pathway
VANOEVELEN MYOGENESIS SIN3A TARGETS 220 133 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
mir-124.1 362 368 M8 HSA-MIR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 362 368 1A hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
HSA-MIR-124brain UAAGGCACGCGGUGAAUGCC
miR-128 164 170 1A hsa-miR-128a ucacagugaaccggucuuuu
hsa-miR-128b ucacagugaaccggucuuc
miR-181 168 174 M8 hsa-miR-181abrain AACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZ AACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrain AACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrain AACAUUCAUUGUUGUCGGUGGGUU
miR-182 455 462 1A，M8 HSA-MIR-182 UUUGGCAAUGGUAGAACUCACA
miR-203.1 89 95 M8 hsa-miR-203 ugaaauguuuaggaccacuag
miR-25/32/92/363/367 435 441 M8 hsa-miR-25brain CAUUGCACUUGUCUCGGUCUGA
hsa-miR-32 uauugcacauacuaaguugc
hsa-miR-92 UAUUGCACUUGUCCCGGCCUG
HSA-MIR-367 AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZ uauugcacucgucccgcgcuc
miR-27 164 171 1A，M8 HSA-MIR-27Abrain uucacaguggcuaaguuccgc
HSA-MIR-27Bbrain UUCACAGUGGCUAAGUUCUGC
mir-323 402 408 M8 hsa-miR-323brain GCACAUUACACGGUCGACCUCU
miR-34b 114 120 M8 hsa-miR-34b UAGGCAGUGUCAUUAGCUGAUUG
mir-450 108 114 M8 hsa-miR-450 UUUUUGCGAUGUGUUCCUAAUA
mir-500 433 440 1A，M8 hsa-miR-500 augcaccuggggaggagauucug
mir-505 448 454 M8 hsa-miR-505 gucaacuugcugguuccuc
miR-96 456 462 1A hsa-miR-96brain uuuggcacuagcacauuuuugc