SZGR2 - Beplay体育中心

Summary?

基因	1399
Symbol	CRKL
同义词	-
描述	v-crk avian sarcoma virus CT10 oncogene homolog-like
参考	MIM:602007\|HGNC:HGNC:2363\|Ensembl:ENSG00000099942\|HPRD：03596\|Vega:OTTHUMG00000150807
基因type	protein-coding
地图位置	22q11.21
Pascal P值	0.235
Sherlock P值	0.371
Fetal beta	0.07
DMG	1（＃研究）

基因in Data Sources

基因set name	基因组方法	描述	Info
CNV：是的	拷贝数变异研究	Manual curation
CV:GWASdb	全基因组关联研究	gwasdbrecords for schizophrenia
简历：PGCNP	全基因组协会研究	GWAS
DMG:Jaffe_2016	Genome-wide DNA methylation analysis	该数据集包括与SZ患者相关的2,104个探针/CPG（n = 108），而在Bonferroni调整后的P <0.05时，其中136个对照。	1
GSMA_I	基因组扫描荟萃分析	Psr: 0.031
网络	Shortest path distance of core genes in the Human protein-protein interaction network	PPI网络中最短路径的贡献：0.1445

Section I. Genetics and epigenetics annotation

差异甲基化基因

探测	Chromosome	Position	最近的基因	P (dis)	beta（dis）	FDR (dis)	Study
cg13720744	22	21271392	CRKL	2.82E-10	-0.014	6.59E-7	DMG:Jaffe_2016

Section II. Transcriptome annotation

基因ral gene expression (GTEx)

Devlopment期间的基因表达（BrainCloud）

Footnote:
总共绘制了269个时间点，n = 38个胎儿样品（x = 1：38）。每个三角形代表一个时间点。

基因expression of temporal and spatial changes (BrainSpan)

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

前10个积极共表达的基因
基因	皮尔逊的相关性	斯皮尔曼的相关性
SLC8A2	0.90	0.91
CCDC85A	0.89	0.90
FBXO41	0.89	0.89
TLN2	0.88	0.89
KIAA1045	0.87	0.89
RAB11FIP4	0.87	0.86
CLSTN1	0.87	0.86
LRP11	0.86	0.89
PIP5K1C	0.86	0.86
SULT4A1	0.86	0.89

前10个负共表达基因
基因	皮尔逊的相关性	斯皮尔曼的相关性
一个P002478.3	-0.52	-0.53
一个L139819.3	-0.51	-0.50
一个F347015.21	-0.51	-0.38
GNG11	-0.48	-0.44
C11orf67	-0.48	-0.51
NSBP1	-0.48	-0.52
C1orf54	-0.48	-0.45
一个F347015.18	-0.47	-0.38
Rab13	-0.46	-0.55
一个L138743.2	-0.46	-0.46

Section III. Gene Ontology annotation

Molecular function	去的术语	Evidence	Neuro keywords	PubMed ID
去：0005070	SH3/SH2适配器活动	塔斯		8798523
GO:0005515	protein binding	新闻学会		9788432\|16284401
GO:0004713	protein tyrosine kinase activity	塔斯		8361759
生物过程	去的术语	Evidence	Neuro keywords	PubMed ID
GO:0001568	血管发育	IEA		-
去：0007265	Ras protein signal transduction	塔斯		8798523
去：0007254	JNK级联	塔斯		8798523
去：0007242	intracellular signaling cascade	塔斯		8361759
GO:0009952	前/后模式形成	IEA		-
GO:0009887	器官形态发生	IEA		-
GO:0007507	heart development	IEA		-
去：0007389	模式规范过程	IEA		-
GO:0060017	甲状旁腺发育	IEA		-
GO：0048538	胸腺发育	IEA		-
细胞分量	去的术语	Evidence	Neuro keywords	PubMed ID
GO:0005737	cytoplasm	艾达		18029348
GO:0005886	质膜	艾达		18029348

Section IV. Protein-protein interaction annotation

Interactors	一个liases B	Official full name B	Experimental	Source	PubMed ID
一个BL1	一个BL \| JTK7 \| bcr/abl \| c-ABL \| p150 \| v-abl	c-abl oncogene 1, receptor tyrosine kinase	一个ffinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	7926767\|8083188 \|8978305\|9820532
一个BL1	一个BL \| JTK7 \| bcr/abl \| c-ABL \| p150 \| v-abl	c-abl oncogene 1, receptor tyrosine kinase	-	HPRD	7493940
ank3	Ankyrin-g \|FLJ45464	ankyrin 3, node of Ranvier (ankyrin G)	一个ffinity Capture-Western	BioGRID	10907644
BCAR1	CAS \| CAS1 \| CASS1 \| CRKAS \| P130Cas	乳腺癌抗雌激素抵抗1	-	HPRD，Biogrid	10753828
BCR	一个LL \| BCR-ABL1 \| BCR1 \| CML \| D22S11 \| D22S662 \| FLJ16453 \| PHL	断点群集区域	一个ffinity Capture-Western 远西方 Two-hybrid	BioGRID	8978305\|9747873 \|10194128\|15143164
BLNK	BASH \| BLNK-S \| LY57 \| MGC111051 \| SLP-65 \| SLP65	B-cell linker	-	HPRD，Biogrid	11489945
CBL	C-CBL \|CBL2 \|RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	一个ffinity Capture-Western Reconstituted Complex	BioGRID	9092574\|9162067 \|9344843\|9461587 \|9590251\|9820532 \|10204582\|10907644 \|11133830\|12244174
CBL	C-CBL \|CBL2 \|RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	-	HPRD	9162067\|9590251 \|12244174
CBLB	DKFZp686J10223 \| DKFZp779A0729 \| DKFZp779F1443 \| FLJ36865 \| FLJ41152 \| Nbla00127 \| RNF56	CAS-BR-M（鼠）生态逆转录病毒转化序列B	-	HPRD，Biogrid	10022120
CD34	-	CD34分子	-	HPRD，Biogrid	11389015
CRK	CRKII	V-CRK肉瘤病毒CT10 ONCOGENE同源物（Avian）	-	HPRD	9614078
DNM2	CMTDI1 \| CMTDIB \| DI-CMTB \| DYN2 \| DYNII	Dynamin 2	一个n unspecified isoform of Dyn2 interacts with CrkL. This interaction was modeled on a demonstrated interaction between human Dyn2 and CrkL from an unspecified species.	BIND	15696170
DOCK2	FLJ46592 \| KIAA0209	dedicator of cytokinesis 2	-	HPRD，Biogrid	12393632
DOK1	MGC117395 \|MGC138860 \|p62dok	对接蛋白1，62KDA（酪氨酸激酶1的下游）	-	HPRD，Biogrid	11071635
EPOR	MGC138358	erythropoietin receptor	-	HPRD，Biogrid	11443118
ETV6	电话\|电话/abl	ETS变体6	一个ffinity Capture-Western	BioGRID	15143164
EVL	RNB6	Enah/Vasp-like	-	HPRD	10945997
FCGR1A	CD64 \| CD64A \| FCRI \| FLJ18345 \| IGFR1	IgG，高亲和力IA，受体的FC片段（CD64）	-	HPRD，Biogrid	9820532
GAB1	-	GRB2相关的结合蛋白1	-	HPRD，Biogrid	10753869
GAB2	KIAA0571	GRB2相关的结合蛋白2	-	HPRD，Biogrid	11334882
GRB2	一个SH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	生长因子受体结合蛋白2	-	HPRD，Biogrid	10477741
IFNAR1	AVP \|IFN-Alpha-Rec \|ifnar \|ifnbr \|IFRC	干扰素（Alpha，beta和Omega）受体1	-	HPRD	11167825
inpp5d	MGC104855 \| MGC142140 \| MGC142142 \| SHIP \| SHIP1 \| SIP-145 \| hp51CN	肌醇聚磷酸5-磷酸酶，145KDA	一个ffinity Capture-Western Reconstituted Complex	BioGRID	11443118
IRS4	IRS-4 \| PY160	胰岛素受体底物4	-	HPRD，Biogrid	9614078
KIDINS220	一个RMS \| MGC163482	kinase D-interacting substrate, 220kDa	-	HPRD	15167895
成套工具	C-Kit \| CD117 \| PBT \| SCFR	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	-	HPRD，Biogrid	9092574
MAP4K1	HPK1	mitogen-activated protein kinase kinase kinase kinase 1	HPK1，Ste-20同源丝氨酸/苏氨酸激酶磷酸化CRKL，一种crk样衔接蛋白	BIND	9891069
MAP4K1	HPK1	mitogen-activated protein kinase kinase kinase kinase 1	-	HPRD，Biogrid	9891069\|11279207
MAP4K5	GCKR \|KHS \|KHS1 \|MAPKKKK5	mitogen-activated protein kinase kinase kinase kinase 5	-	HPRD，Biogrid	10648385
nedd9	CAS-L \| CAS2 \| CASL \| CASS2 \| HEF1 \| dJ49G10.2 \| dJ761I2.1	neural precursor cell expressed, developmentally down-regulated 9	-	HPRD	9020138\|9405482 \|9498705
nedd9	CAS-L \| CAS2 \| CASL \| CASS2 \| HEF1 \| dJ49G10.2 \| dJ761I2.1	neural precursor cell expressed, developmentally down-regulated 9	一个ffinity Capture-Western Reconstituted Complex	BioGRID	9020138\|9162067 \|9498705\|9820532
PDGFRA	CD140A \| MGC74795 \| PDGFR2 \| Rhe-PDGFRA	血小板源生长因子受体α波尔ypeptide	-	HPRD，Biogrid	9546424
PIK3R1	grb1 \|P85 \|p85-alpha	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	一个ffinity Capture-Western	BioGRID	9461587
PIK3R2	P85B \| p85 \| p85-BETA	磷酸肌醇3-激酶，调节亚基2（beta）	-	HPRD，Biogrid	9092574
PTK2	Fadk \|fak \|fak1 \|pp125fak	PTK2蛋白酪氨酸激酶2	Two-hybrid	BioGRID	15494733
PTPN11	BPTP3 \| CFC \| MGC14433 \| NS1 \| PTP-1D \| PTP2C \| SH-PTP2 \| SH-PTP3 \| SHP2	protein tyrosine phosphatase, non-receptor type 11	-	HPRD，Biogrid	9344843
PXN	FLJ16691	帕西林	-	HPRD，Biogrid	7493940
RAPGEF1	C3G \|DKFZP781P1719 \|GRF2	RAP鸟嘌呤核苷酸交换因子（GEF）1	Crk-L interacts with C3G.	BIND	8621483
RAPGEF1	C3G \|DKFZP781P1719 \|GRF2	RAP鸟嘌呤核苷酸交换因子（GEF）1	-	HPRD，Biogrid	8621483\|9344843 \|9374471
RICS	GC-GAP \| GRIT \| KIAA0712 \| MGC1892 \| p200RhoGAP \| p250GAP	Rho GTPase-activating protein	-	HPRD，Biogrid	12446789
SHC1	FLJ26504 \|SHC \|SHCA	SHC (Src homology 2 domain containing) transforming protein 1	-	HPRD，Biogrid	9344843
SOS1	GF1 \|GGF1 \|gingf \|HGF \|NS4	son of sevenless homolog 1 (Drosophila)	-	HPRD	9162067
Stat5a	MGF \|Stat5	信号换能器和转录5a激活剂	-	HPRD，Biogrid	9837784\|11167825
Syk	dkfzp313n1010 \|FLJ25043 \|FLJ37489	spleen tyrosine kinase	CrkL与麦克米兰。	BIND	11313252
Syk	dkfzp313n1010 \|FLJ25043 \|FLJ37489	spleen tyrosine kinase	-	HPRD，Biogrid	11313252
TGFB1I1	ARA55 \|HIC-5 \|Hic5 \|TSC-5	transforming growth factor beta 1 induced transcript 1	-	HPRD	9858471\|11463817
tyk2	JTK1	酪氨酸激酶2	-	HPRD，Biogrid	9374471
曾是	IMD2 \|THC \|黄蜂	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	-	HPRD，Biogrid	11313252
曾是	IMD2 \|THC \|黄蜂	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	CRKL与黄蜂相互作用。	BIND	11313252
WIPF1	MGC111041 \|prpl-2 \|WASPIP \|WIP	曾是/WASL interacting protein family, member 1	WIP与CRKL相互作用。	BIND	12504004
ZAP70	FLJ17670 \| FLJ17679 \| SRK \| STD \| TZK \| ZAP-70	zeta-chain (TCR) associated protein kinase 70kDa	ZAP-70与CRKL相互作用。这种相互作用是根据未指定物种的人类ZAP-70与CRKL之间的相互作用进行建模的。	BIND	10419455

Section V. Pathway annotation

Pathway name	Pathway size	＃szgr 2.0基因	Info
KEGG MAPK SIGNALING PATHWAY	267	205	一个ll SZGR 2.0 genes in this pathway
kegg erbb信号通路	87	71	一个ll SZGR 2.0 genes in this pathway
KEGG CHEMOKINE SIGNALING PATHWAY	190	128	一个ll SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION	201	138	一个ll SZGR 2.0 genes in this pathway
KEGG FC GAMMA R MEDIATED PHAGOCYTOSIS	97	71	一个ll SZGR 2.0 genes in this pathway
KEGG神经营养蛋白信号传导途径	126	103	一个ll SZGR 2.0 genes in this pathway
肌动蛋白细胞骨架的KEGG调节	216	144	一个ll SZGR 2.0 genes in this pathway
KEGG胰岛素信号通路	137	103	一个ll SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	一个ll SZGR 2.0 genes in this pathway
KEGG RENAL CELL CARCINOMA	70	60	一个ll SZGR 2.0 genes in this pathway
KEGG CHRONIC MYELOID LEUKEMIA	73	59	一个ll SZGR 2.0 genes in this pathway
Biocarta IL2RB途径	38	26	一个ll SZGR 2.0 genes in this pathway
BIOCARTA GLEEVEC PATHWAY	23	17	一个ll SZGR 2.0 genes in this pathway
BIOCARTA INTEGRIN PATHWAY	38	29	一个ll SZGR 2.0 genes in this pathway
BIOCARTA PYK2 PATHWAY	31	24	一个ll SZGR 2.0 genes in this pathway
BIOCARTA MET PATHWAY	37	30	一个ll SZGR 2.0 genes in this pathway
PC12细胞中的ST分化途径	45	35	一个ll SZGR 2.0 genes in this pathway
PID遇到了路径	80	60	一个ll SZGR 2.0 genes in this pathway
PID REELIN PATHWAY	29	29	一个ll SZGR 2.0 genes in this pathway
PID IGF1 PATHWAY	30	23	一个ll SZGR 2.0 genes in this pathway
PID IFNG途径	40	34	一个ll SZGR 2.0 genes in this pathway
PID Epha FWDPathway	34	29	一个ll SZGR 2.0 genes in this pathway
PID TRKR途径	62	48	一个ll SZGR 2.0 genes in this pathway
PID TCR JNK PATHWAY	14	11	一个ll SZGR 2.0 genes in this pathway
PID PDGFRA PATHWAY	22	18	一个ll SZGR 2.0 genes in this pathway
PID套件途径	52	40	一个ll SZGR 2.0 genes in this pathway
PID EPO PATHWAY	34	29	一个ll SZGR 2.0 genes in this pathway
PDGF的Reactome信号传导	122	93	一个ll SZGR 2.0 genes in this pathway
Reactome下游信号转导	95	76	一个ll SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS	107	86	一个ll SZGR 2.0 genes in this pathway
CBL对信号的反应组调节	18	16	一个ll SZGR 2.0 genes in this pathway
Reactome IL 3 5和GM CSF信号传导	43	34	一个ll SZGR 2.0 genes in this pathway
Reactome免疫系统	933	616	一个ll SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	270	204	一个ll SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	一个ll SZGR 2.0 genes in this pathway
EWSR1 FLII融合的Kinsey目标	1278	748	一个ll SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN	459	276	一个ll SZGR 2.0 genes in this pathway
BIDUS METASTASIS UP	214	134	一个ll SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP	1142	669	一个ll SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA PROGRESSION RISK	74	44	一个ll SZGR 2.0 genes in this pathway
洛克伍德在肺癌中放大	214	139	一个ll SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS	882	572	一个ll SZGR 2.0 genes in this pathway
Browne HCMV感染8小时	105	73	一个ll SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	一个ll SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV SCC DN	123	86	一个ll SZGR 2.0 genes in this pathway
外邦紫外线高剂量DN	312	203	一个ll SZGR 2.0 genes in this pathway
外邦响应集群D3	61	39	一个ll SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS DN	120	81	一个ll SZGR 2.0 genes in this pathway
一个CEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP	863	514	一个ll SZGR 2.0 genes in this pathway
Bochkis foxa2目标	425	261	一个ll SZGR 2.0 genes in this pathway
BONCI TARGETS OF MIR15A AND MIR16 1	91	75	一个ll SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP	442	263	一个ll SZGR 2.0 genes in this pathway
ZEMBUTSU SENSITIVITY TO NIMUSTINE	17	13	一个ll SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A	770	480	一个ll SZGR 2.0 genes in this pathway
HOLLEMAN PREDNISOLONE RESISTANCE ALL UP	19	15	一个ll SZGR 2.0 genes in this pathway

第六节。microRNA注释

miRNA family	目标位置			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-128	3565	3571	m8	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	3565	3571	m8	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-15/16/195/424/497	20	26	m8	hsa-miR-15a^脑	uagcagcacauaugguugug
				HSA-MIR-16^脑	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^脑	uagcagcacaucaugguuaca
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				HSA-MIR-424	Cagcagcaauucauguuuugaa
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
mir-188	3259	3265	m8	hsa-miR-188	CAUCCCUUGCAUGGUGGAGGGU
MiR-200BC/429	3728	3735	1a,m8	hsa-miR-200b	uaauacugccugguaaugaugac
				hsa-miR-200c	uaauacugccggguaaugaugg
				HSA-MIR-429	uaauacuguguguguguguaaaaaccgu
miR-204/211	3258	3264	m8	hsa-miR-204^脑	Uucccuuugucauccuaugccu
miR-204/211	3258	3264	m8	hsa-miR-211	uucccuuugucauccuucgccu
miR-214	18	24	m8	hsa-miR-214^脑	acagcaggcacagacaggcag
miR-224	3738	3744	1a	hsa-miR-224	caagucacuaguguguccuuua
miR-30-5p	3174	3181	1a,m8	hsa-miR-30a-5p	uguaaaacauccuccugagaag
				HSA-MIR-30C^脑	UGUAAACAUCCUACACUCUCAGC
				HSA-MIR-30D^SZ	UGUAAACAUCCCCGACUGGAAG
				HSA-MIR-30B^SZ	UGUAAACAUCCUACACUCAGCU
				HSA-MIR-30E-5P	uguaaacauccuugacugga
miR-335	3212	3218	m8	hsa-miR-335^脑	UCAAGAGCAAUAACGAAAAAUAUGU
mir-96	2612	2619	1a,m8	HSA-MIR-96^脑	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Clickhere查看与SZ相关的miRNA列表。
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Clickhereto see the list of brain related miRNAs.

基因页：CRKL