Gene Page:MAPK14

Summary?
GeneID 1432
象征 MAPK14
同义词 CSBP | CSBP1 | CSBP2 | CSPB1 | EXIP | MXI2 | PRKM14 | PRKM15 | RK | RK | SAPK2A | P38 | P38ALPHA
描述 mitogen-activated protein kinase 14
参考 MIM:600289|HGNC:HGNC:6876|Ensembl:ENSG00000112062|HPRD：02619|Vega:OTTHUMG00000159806
基因类型 protein-coding
Map location 6p21.3-p21.2
Pascal P值 0.699
Fetal beta 0.459
eGene 皮质

Gene in Data Sources
Gene set name 基因组方法 描述 Info
简历：PGCNP Genome-wide Association Study GWAS
PMID:cooccur 高通量文献搜索 Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I Genome scan meta-analysis PSR：0.033
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.04433
文学 高通量文献搜索 Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias 点击to show details
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0305

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Devlopment期间的基因表达（BrainCloud）

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
去：0004707 MAP kinase activity IEA -
去：0004708 MAP激酶激酶活性 TAS 10706854
GO:0008339 MP kinase activity IDA 7997261
GO:0005515 protein binding IPI 9792677|12761180|16189514
|16636664|16751104
|17255097
GO:0005524 ATP binding IEA -
GO:0004674 protein serine/threonine kinase activity 经验 8846784|9687510
GO:0004674 protein serine/threonine kinase activity IEA -
GO:0016740 transferase activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006468 蛋白氨基酸磷酸化 IEA -
GO:0007265 Ras protein signal transduction 经验 11520933
GO:0007243 protein kinase cascade IDA 10838079
GO:0006950 response to stress IDA 7997261
去：0007166 细胞表面受体连接的信号转导 TAS 10706854
GO:0006935 chemotaxis TAS 10706854
去：0006928 细胞运动 TAS 10912793
细胞分量 去的术语 Evidence Neuro keywords PubMed ID
去：0005829 cytosol 经验 9687510
GO:0005634 核 ISS -
GO:0005654 核质 经验 8846784
GO:0005737 细胞质 ISS -

Section IV. Protein-protein interaction annotation

互动者 别名b 官方全名b Experimental 资源 PubMed ID
AKT1 akt |MGC99656 |PKB |pkb-alpha |Prkba |RAC |Rac-Alpha v-akt murine thymoma viral oncogene homolog 1 Affinity Capture-Western
Biochemical Activity		 BioGRID 11042204
ATF2 CRE-BP1 |creb2 |HB16 |MGC111558 |Treb7 激活转录因子2 p38的未指定同工型与ATF2相互作用并磷酸化。 BIND 9155018
ATF2 CRE-BP1 |creb2 |HB16 |MGC111558 |Treb7 激活转录因子2 p38的未指定同工型与ATF2相互作用并磷酸化。 BIND 9235954
ATF2 CRE-BP1 |creb2 |HB16 |MGC111558 |Treb7 激活转录因子2 p38 phosphorylates ATF2. This interaction was modelled on a demonstrated interaction between human p38 and ATF2 from an unspecified species. BIND 15692053
ATF2 CRE-BP1 |creb2 |HB16 |MGC111558 |Treb7 激活转录因子2 - HPRD,BioGRID 7535770
CDC25A CDC25A2 cell division cycle 25 homolog A (S. pombe) Reconstituted Complex BioGRID 12963847
CDC25B - 细胞分裂周期25同源物B（S. pombe） Biochemical Activity
Reconstituted Complex		 BioGRID 11333986
CDC25B - 细胞分裂周期25同源物B（S. pombe） p38-alpha interacts with and phosphorylates CDC25B. BIND 15629715
CDC25C CDC25 细胞分裂周期25同源C（S。Pombe） - HPRD,BioGRID 11333986
CREB1 CREB | MGC9284 cAMP responsive element binding protein 1 - HPRD,BioGRID 11377386
CSNK2A1 CK2A1 | CKII casein kinase 2, alpha 1 polypeptide Affinity Capture-Western
Reconstituted Complex		 BioGRID 10747897
CSNK2A2 CK2A2 | CSNK2A1 | FLJ43934 酪蛋白激酶2，α素多肽 - HPRD 10747897
CSNK2B CK2B |CK2N |CSK2B |g5a |MGC138222 |MGC138224 casein kinase 2, beta polypeptide - HPRD 10747897
DDIT3 Cebpz |切碎|Chop10 |GADD153 |MGC4154 DNA-damage-inducible transcript 3 - HPRD,BioGRID 8650547
DUSP1 CL100 | HVH1 | MKP-1 | MKP1 | PTPN10 dual specificity phosphatase 1 - HPRD 7535770
DUSP1 CL100 | HVH1 | MKP-1 | MKP1 | PTPN10 dual specificity phosphatase 1 Affinity Capture-Western
Two-hybrid		 BioGRID 11278799|11359773
DUSP10 MKP-5 |MKP5 双重特异性磷酸酶10 Affinity Capture-Western
Biochemical Activity
Reconstituted Complex
Two-hybrid		 BioGRID 10391943|11157753
|11359773
DUSP10 MKP-5 |MKP5 双重特异性磷酸酶10 An unspecified isoform of MAPK14 interacts with DUSP10. BIND 10391943
DUSP10 MKP-5 |MKP5 双重特异性磷酸酶10 - HPRD 10391943|10597297
|11359773
DUSP16 KIAA1700 |MGC129701 |MGC129702 |MKP-7 |MKP7 双重特异性磷酸酶16 - HPRD,BioGRID 11359773|11489891
|14586399
DUSP2 Pac-1 |PAC1 dual specificity phosphatase 2 - HPRD 7535770
DUSP22 JKAP | JSP1 | MKPX | VHX 双重特异性磷酸酶22 - HPRD 11346645
DUSP4 HVH2 | MKP-2 | MKP2 | TYP dual specificity phosphatase 4 - HPRD,BioGRID 11387337
DUSP6 MKP3 | PYST1 dual specificity phosphatase 6 Affinity Capture-Western BioGRID 11359773
dyrk1b MIRK dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B - HPRD,BioGRID 10910078
EGFR ERBB |ERBB1 |her1 |PIG61 |梅纳 epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) Biochemical Activity BioGRID 7535770
ELK1 - ELK1，ETS OTOGENE家族的成员 ELK-1由p38 MAPK的未指定同工型磷酸化。这种相互作用是基于未指定物种的人类ELK-1和p38 MAPK之间的相互作用建模的。 BIND 9130707
ELK1 - ELK1，ETS OTOGENE家族的成员 - HPRD 8622669
ELK1 - ELK1，ETS OTOGENE家族的成员 An unspecified isoform of p38 interacts with and phosphorylates Elk-1. BIND 9155018
ELK4 SAP1 ELK4, ETS-domain protein (SRF accessory protein 1) An unspecified isoform of p38 interacts with and phosphorylates Sap-1a. BIND 9235954
ELK4 SAP1 ELK4, ETS-domain protein (SRF accessory protein 1) Sap-1a is phosphorylated by an unspecified isoform of p38 MAPK. This interaction was modeled on a demonstrated interaction between human Sap-1a and p38 MAPK from an unspecified species. BIND 9130707
ETV1 DKFZp781L0674 | ER81 | MGC104699 | MGC120533 | MGC120534 ets variant 1 Biochemical Activity BioGRID 11551945
FLNA ABP-280 |ABPX |DKFZP434P031 |fln |fln1 |FMD |MNS |NHBP |OPD |OPD1 | OPD2 filamin A, alpha (actin binding protein 280) - HPRD 11390380
FUBP1 FBP |fubp 上游元素（保险丝）结合蛋白1 Affinity Capture-Western
Reconstituted Complex
Two-hybrid		 BioGRID 12819782
GMFB GMF glia maturation factor, beta - HPRD,BioGRID 8798479
GRB2 ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084 生长因子受体结合蛋白2 - HPRD 8695800
HTRA2 omi |Park13 |PRSS25 HtrA serine peptidase 2 - HPRD,BioGRID 10644717
JUN AP-1 | AP1 | c-Jun jun oncogene An unspecified isoform of p38 interacts with and phosphorylates c-Jun. BIND 9155018
kars kars2 | KIAA0070 | KRS 赖氨酸-TRNA合成酶 Two-hybrid BioGRID 12819782
KRT18 CYK18 |K18 角蛋白18 - HPRD,BioGRID 11788583
MAP2K1 mapkk1 |MEK1 |MKK1 |prkmk1 有丝分裂原激活的蛋白激酶激酶1 - HPRD 12697810
MAP2K3 MAPKK3 |mek3 |MKK3 |prkmk3 有丝分裂原激活的蛋白激酶激酶3 - HPRD 7839144|8622669
MAP2K3 MAPKK3 |mek3 |MKK3 |prkmk3 有丝分裂原激活的蛋白激酶激酶3 Biochemical Activity BioGRID 11279118
MAP2K3 MAPKK3 |mek3 |MKK3 |prkmk3 有丝分裂原激活的蛋白激酶激酶3 MKK3磷酸化p38的未指定同工型。这种相互作用是基于未指定物种的人类MKK3和p38之间的相互作用进行建模的。 BIND 8622669
MAP2K4 jnkk |jnkk1 |MAPKK4 |MEK4 |MKK4 |prkmk4 |sek1 |SERK1 有丝分裂原激活的蛋白激酶激酶4 - HPRD,BioGRID 7716521
MAP2K6 MAPKK6 | MEK6 | MKK6 | PRKMK6 | SAPKK3 有丝分裂原激活的蛋白激酶激酶6 - HPRD,BioGRID 8626699
MAP2K7 jnkk2 |MAPKK7 |MKK7 |prkmk7 有丝分裂原激活的蛋白激酶激酶7 Biochemical Activity BioGRID 9207092
MAP3K7IP1 3'-Tab1 | MGC57664 | TAB1 mitogen-activated protein kinase kinase kinase 7 interacting protein 1 TAB1与p38的未指定同工型相互作用。 BIND 12829618
MAP3K7IP1 3'-Tab1 | MGC57664 | TAB1 mitogen-activated protein kinase kinase kinase 7 interacting protein 1 - HPRD,BioGRID 11847341
MAPK1 ERK | ERK2 | ERT1 | MAPK2 | P42MAPK | PRKM1 | PRKM2 | p38 | p40 | p41 | p41mapk mitogen-activated protein kinase 1 - HPRD,BioGRID 12697810
MAPK14 CSBP1 | CSBP2 | CSPB1 | EXIP | Mxi2 | PRKM14 | PRKM15 | RK | SAPK2A | p38 | p38ALPHA mitogen-activated protein kinase 14 Biochemical Activity
Two-hybrid		 BioGRID 11847341|12819782
MAPK3 ERK1 | HS44KDAP | HUMKER1A | MGC20180 | P44ERK1 | P44MAPK | PRKM3 mitogen-activated protein kinase 3 - HPRD,BioGRID 12697810
MAPKAPK2 MK2 mitogen-activated protein kinase-activated protein kinase 2 - HPRD,BioGRID 9768359|11042204
|11551945
MAPKAPK3 3PK | MAPKAP3 mitogen-activated protein kinase-activated protein kinase 3 - HPRD,BioGRID 11157753
火星 FLJ35667 | METRS | MTRNS methionyl-tRNA synthetase - HPRD 9878398
MEF2A ADCAD1 |RSRFC4 |RSRFC9 myocyte enhancer factor 2A - HPRD,BioGRID 10330143
MEF2C - 心肌细胞增强因子2C - HPRD 9753748|10330143
MKNK1 MNK1 MAP kinase interacting serine/threonine kinase 1 - HPRD 9155018
MKNK1 MNK1 MAP kinase interacting serine/threonine kinase 1 Affinity Capture-Western BioGRID 11157753
MKNK1 MNK1 MAP kinase interacting serine/threonine kinase 1 An unspecified isoform of p38 interacts with and phosphorylates MNK1. BIND 9155018
MKNK2 gprk7 |mnk2 MAP kinase interacting serine/threonine kinase 2 - HPRD 12897141
NCF1C SH3PXD1C neutrophil cytosolic factor 1C pseudogene p38-alpha interacts with and phosphorylates p47phox. BIND 15629715
PLCB2 FLJ38135 phospholipase C, beta 2 Affinity Capture-Western BioGRID 12054652
PML MYL | PP8675 | RNF71 | TRIM19 Promyelocytic白血病 - HPRD 15273249
PTPN7 BPTP-4 |HEPTP |LC-PTP |LPTP |ptpni 蛋白质酪氨酸磷酸酶，非受体7型 - HPRD 10559944
RPS6KA3 CLS | HU-3 | ISPK-1 | MAPKAPK1B | MRX19 | RSK | RSK2 | S6K-alpha3 | p90-RSK2 | pp90RSK2 核糖体蛋白S6激酶，90KDA，多肽3 Affinity Capture-Western BioGRID 11157753
RPS6KA4 MSK2 |RSK-B 核糖体蛋白S6激酶，90KDA，多肽4 - HPRD,BioGRID 9792677
RPS6KA5 MGC1911 |MSK1 |MSPK1 |rlpk 核糖体蛋白S6激酶，90KDA，多肽5 Affinity Capture-Western BioGRID 11157753
SCYE1 AIMP1 | EMAP-2 | EMAP-II | EMAP2 | EMAPII | p43 small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating) - HPRD 9878398
SLC12A2 BSC | BSC2 | MGC104233 | NKCC1 溶质载体家族12（钠/钾/氯化物转运蛋白），成员2 Affinity Capture-Western BioGRID 14563843
SLC44A1 CD92 | CDW92 | CHTL1 | CTL1 | RP11-287A8.1 Solute Carrier家族44，会员1 - HPRD 9707433
Smad7 CRCS3 | FLJ16482 | MADH7 | MADH8 SMAD family member 7 - HPRD,BioGRID 12589052
意大利面9 FLJ13450 |FLJ14006 |FLJ26141 |FLJ34602 |HLC4 |JLP |KIAA0516 |MGC117291 |MGC14967 |MGC74461 | PHET | PIG6 sperm associated antigen 9 - HPRD,BioGRID 12391307
STK39 DCHT | DKFZp686K05124 | PASK | SPAK 丝氨酸苏氨酸激酶39（Ste20/sps1同源物，酵母） - HPRD 10980603
STK39 DCHT | DKFZp686K05124 | PASK | SPAK 丝氨酸苏氨酸激酶39（Ste20/sps1同源物，酵母） Affinity Capture-Western BioGRID 14563843
ZFP36L1 BRF1 |Berg36 |ERF-1 |ERF1 |RNF162B |tis11b |CMG1 锌指蛋白36，c3h类型1 Affinity Capture-Western
Two-hybrid		 BioGRID 16189514


Section V. Pathway annotation

Pathway name Pathway size ＃szgr 2.0基因 Info
KEGG MAPK SIGNALING PATHWAY 267 205 All SZGR 2.0 genes in this pathway
KEGG VEGF SIGNALING PATHWAY 76 53 All SZGR 2.0 genes in this pathway
Kegg Toll像受体信号通路 102 88 All SZGR 2.0 genes in this pathway
kegg点头喜欢受体信号通路 62 47 All SZGR 2.0 genes in this pathway
KEGG RIG I LIKE RECEPTOR SIGNALING PATHWAY 71 51 All SZGR 2.0 genes in this pathway
kegg t细胞受体信号通路 108 89 All SZGR 2.0 genes in this pathway
KEGG FC EPSILON RI SIGNALING PATHWAY 79 58 All SZGR 2.0 genes in this pathway
KEGG LEUKOCYTE TRANSENDOTHELIAL MIGRATION 118 78 All SZGR 2.0 genes in this pathway
KEGG神经营养蛋白信号传导途径 126 103 All SZGR 2.0 genes in this pathway
KEGG GNRH SIGNALING PATHWAY 101 77 All SZGR 2.0 genes in this pathway
KEGG PROGESTERONE MEDIATED OOCYTE MATURATION 86 59 All SZGR 2.0 genes in this pathway
KEGG肌萎缩性侧索硬化症ALS 53 43 All SZGR 2.0 genes in this pathway
KEGG EPITHELIAL CELL SIGNALING IN HELICOBACTER PYLORI INFECTION 68 44 All SZGR 2.0 genes in this pathway
KEGG LEISHMANIA INFECTION 72 56 All SZGR 2.0 genes in this pathway
BIOCARTA BCR PATHWAY 37 28 All SZGR 2.0 genes in this pathway
BIOCARTA BIOPEPTIDES PATHWAY 45 35 All SZGR 2.0 genes in this pathway
BIOCARTA HDAC通路 32 25 All SZGR 2.0 genes in this pathway
BIOCARTA FMLP PATHWAY 39 29 All SZGR 2.0 genes in this pathway
Biocarta GATA3途径 16 15 All SZGR 2.0 genes in this pathway
Biocarta HCMV途径 17 16 All SZGR 2.0 genes in this pathway
Biocarta IL12途径 23 17 All SZGR 2.0 genes in this pathway
BIOCARTA KERATINOCYTE PATHWAY 46 38 All SZGR 2.0 genes in this pathway
BIOCARTA PYK2 PATHWAY 31 24 All SZGR 2.0 genes in this pathway
BIOCARTA EGFR SMRTE PATHWAY 11 11 All SZGR 2.0 genes in this pathway
Biocarta MAPK途径 87 68 All SZGR 2.0 genes in this pathway
Biocarta NFAT途径 56 45 All SZGR 2.0 genes in this pathway
BIOCARTA NTHI PATHWAY 24 20 All SZGR 2.0 genes in this pathway
Biocarta Arenrf2途径 13 9 All SZGR 2.0 genes in this pathway
Biocarta P38MAPK途径 40 31 All SZGR 2.0 genes in this pathway
Biocarta CCR5途径 20 16 All SZGR 2.0 genes in this pathway
BIOCARTA RB PATHWAY 13 11 All SZGR 2.0 genes in this pathway
BIOCARTA EIF4 PATHWAY 24 19 All SZGR 2.0 genes in this pathway
Biocarta IL1R途径 33 29 All SZGR 2.0 genes in this pathway
BIOCARTA TALL1 PATHWAY 15 15 All SZGR 2.0 genes in this pathway
Biocarta 41BB途径 17 15 All SZGR 2.0 genes in this pathway
BIOCARTA SARS通路 10 5 All SZGR 2.0 genes in this pathway
BIOCARTA STRESS PATHWAY 25 18 All SZGR 2.0 genes in this pathway
BIOCARTA TOLL PATHWAY 37 31 All SZGR 2.0 genes in this pathway
BIOCARTA CREB PATHWAY 27 25 All SZGR 2.0 genes in this pathway
SIG CD40Pathwaymap 34 28 All SZGR 2.0 genes in this pathway
ST P38 MAPK PATHWAY 37 28 All SZGR 2.0 genes in this pathway
ST ADRENERGIC 36 29 All SZGR 2.0 genes in this pathway
PID ENDOTHELIN PATHWAY 63 52 All SZGR 2.0 genes in this pathway
PID BCR 5PATHWAY 65 50 All SZGR 2.0 genes in this pathway
PID P73Pathway 79 59 All SZGR 2.0 genes in this pathway
PID P38 MKK3 6PATHWAY 26 21 All SZGR 2.0 genes in this pathway
PID NFKAPPAB ATYPICAL PATHWAY 17 15 All SZGR 2.0 genes in this pathway
PID IL4 2PATHWAY 65 43 All SZGR 2.0 genes in this pathway
PID CD40途径 31 26 All SZGR 2.0 genes in this pathway
PID IL12 2 Pathway 63 54 All SZGR 2.0 genes in this pathway
PID p38 alpha beta途径 31 25 All SZGR 2.0 genes in this pathway
PID CDC42 PATHWAY 70 51 All SZGR 2.0 genes in this pathway
PID ANGIOPOIETIN RECEPTOR PATHWAY 50 41 All SZGR 2.0 genes in this pathway
PID FAS PATHWAY 38 29 All SZGR 2.0 genes in this pathway
PID TXA2 Pathway 57 43 All SZGR 2.0 genes in this pathway
PID NFAT 3 Pathway 54 47 All SZGR 2.0 genes in this pathway
PID REG GR PATHWAY 82 60 All SZGR 2.0 genes in this pathway
PID IL2 1PATHWAY 55 43 All SZGR 2.0 genes in this pathway
PID AR TF途径 53 38 All SZGR 2.0 genes in this pathway
PID ATF2途径 59 43 All SZGR 2.0 genes in this pathway
PID IL6 7途径 47 40 All SZGR 2.0 genes in this pathway
PID P38 MK2 PATHWAY 21 19 All SZGR 2.0 genes in this pathway
pid视黄酸途径 30 23 All SZGR 2.0 genes in this pathway
PID CXCR3 PATHWAY 43 34 All SZGR 2.0 genes in this pathway
PID P38 ALPHA BETA DOWNSTREAM PATHWAY 38 29 All SZGR 2.0 genes in this pathway
PID EPO途径 34 29 All SZGR 2.0 genes in this pathway
PID VEGFR1 2 PATHWAY 69 57 All SZGR 2.0 genes in this pathway
PID P53 REGULATION PATHWAY 59 50 All SZGR 2.0 genes in this pathway
PID S1P S1P2 PATHWAY 24 19 All SZGR 2.0 genes in this pathway
PID MAPK TRK途径 34 31 All SZGR 2.0 genes in this pathway
PID淋巴血管生成途径 25 16 All SZGR 2.0 genes in this pathway
PID Rac1途径 54 37 All SZGR 2.0 genes in this pathway
PID RB 1 Pathway 65 46 All SZGR 2.0 genes in this pathway
REACTOME信号通过神经生长因子 217 167 All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396 292 All SZGR 2.0 genes in this pathway
REACTOME TRIF MEDIATED TLR3 SIGNALING 74 54 All SZGR 2.0 genes in this pathway
Reactome细胞通信 120 77 All SZGR 2.0 genes in this pathway
Reactome对RAS的信号传导 27 23 All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 137 105 All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO ERKS 36 30 All SZGR 2.0 genes in this pathway
Reactome P38MAPK事件 13 12 All SZGR 2.0 genes in this pathway
REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 24 20 All SZGR 2.0 genes in this pathway
Reactome Erk MAPK目标 21 17 All SZGR 2.0 genes in this pathway
REACTOME ADP SIGNALLING THROUGH P2RY1 25 16 All SZGR 2.0 genes in this pathway
REACTOME SIGNAL AMPLIFICATION 31 19 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF MRNA 284 128 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA 330 155 All SZGR 2.0 genes in this pathway
REACTOME MYOGENESIS 28 20 All SZGR 2.0 genes in this pathway
REACTOME MAP KINASE ACTIVATION IN TLR CASCADE 50 37 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS 10 8 All SZGR 2.0 genes in this pathway
REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 30 24 All SZGR 2.0 genes in this pathway
Reactome激活的TA​​K1介导P38 MAPK激活 18 12 All SZGR 2.0 genes in this pathway
REACTOME PLATELET HOMEOSTASIS 78 49 All SZGR 2.0 genes in this pathway
REACTOME PLATELET SENSITIZATION BY LDL 16 9 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 84 50 All SZGR 2.0 genes in this pathway
Reactome Traf6在TLR7 8或9激活上介导的NFKB和MAP激酶的诱导 77 57 All SZGR 2.0 genes in this pathway
REACTOME DESTABILIZATION OF MRNA BY KSRP 17 9 All SZGR 2.0 genes in this pathway
Reactome NFKB和MAP激酶激活由TLR4信号传导介导 72 53 All SZGR 2.0 genes in this pathway
Reactome DSCAM相互作用 11 10 All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466 331 All SZGR 2.0 genes in this pathway
Reactome myd88 mal级联反应于质膜发起 83 63 All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM 279 178 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED TLR4 SIGNALLING 93 69 All SZGR 2.0 genes in this pathway
Reactome免疫系统 933 616 All SZGR 2.0 genes in this pathway
REACTOME TOLL RECEPTOR CASCADES 118 84 All SZGR 2.0 genes in this pathway
REACTOME NOD1 2 SIGNALING PATHWAY 30 22 All SZGR 2.0 genes in this pathway
REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 46 33 All SZGR 2.0 genes in this pathway
Reactome血小板激活信号传导和聚集 208 138 All SZGR 2.0 genes in this pathway
LIU SOX4 TARGETS DN 309 191 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE DN 384 220 All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663 425 All SZGR 2.0 genes in this pathway
Senese HDAC3靶向 501 327 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN 459 276 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722 443 All SZGR 2.0 genes in this pathway
hahtola兄弟姐妹fungoides cd4 up 64 46 All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR DN 64 39 All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR DN 75 50 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 5 6WK DN 137 97 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 6 7WK UP 197 135 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL TGFB1 TARGETS UP 169 127 All SZGR 2.0 genes in this pathway
GALLUZZI PREVENT MITOCHONDIAL PERMEABILIZATION 22 16 All SZGR 2.0 genes in this pathway
Dacosta UV响应通过ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
WANG RESPONSE TO BEXAROTENE DN 29 19 All SZGR 2.0 genes in this pathway
通过ELK3 UP总缺氧 209 139 All SZGR 2.0 genes in this pathway
仅通过ELK3 DN的缺氧总缺氧 44 30 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN 637 377 All SZGR 2.0 genes in this pathway
RANKIN ANGIOGENIC TARGETS OF VHL HIF2A UP 5 5 All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN 206 136 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT OK VS DONOR DN 41 30 All SZGR 2.0 genes in this pathway
UEDA PERIFERAL CLOCK 169 111 All SZGR 2.0 genes in this pathway
TENEDINI MEGAKARYOCYTE MARKERS 66 48 All SZGR 2.0 genes in this pathway
Flechner PBL肾脏移植被拒绝与OK DN 51 35 All SZGR 2.0 genes in this pathway
PARK HSC AND MULTIPOTENT PROGENITORS 50 33 All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP 412 249 All SZGR 2.0 genes in this pathway
Hoegerkorp CD44靶向直接 27 21 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
村上紫外线响应6小时 37 31 All SZGR 2.0 genes in this pathway
Kayo衰老肌肉DN 123 76 All SZGR 2.0 genes in this pathway
Browne HCMV感染48小时DN 504 323 All SZGR 2.0 genes in this pathway
ZHU CMV 8 HR DN 53 40 All SZGR 2.0 genes in this pathway
ZHU CMV ALL DN 128 93 All SZGR 2.0 genes in this pathway
GENTILE UV RESPONSE CLUSTER D8 40 29 All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN DN 271 175 All SZGR 2.0 genes in this pathway
monnier tradiatiation肿瘤逃脱 393 244 All SZGR 2.0 genes in this pathway
Yoshimura mapk8靶向 1305 895 All SZGR 2.0 genes in this pathway
Yoshimura MAPK8目标DN 366 257 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN 457 302 All SZGR 2.0 genes in this pathway
Sasson对促性腺营养蛋白DN的反应 87 66 All SZGR 2.0 genes in this pathway
Sasson对Forskolin的反应 90 58 All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE UP 242 159 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504 321 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 DN 336 211 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族 目标位置 mirna id miRNA seq
UTR start UTR end Match method
miR-124.1 605 612 1a,m8 HSA-MIR-124A UUAAGGCACGCGGUGAAUGCCA
miR-124/506 604 611 1a,m8 HSA-MIR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124脑 UAAGGCACGCGGUGAAUGCC
miR-125/351 1610 1616年 M8 HSA-MIR-125B脑 UCCCUGAGACCCUAACUUGUGA
HSA-MIR-125A脑 ucccugagacccuuaaccugug
miR-128 32 39 1a,m8 HSA-MIR-128A ucacagugaaccggucuuuu
HSA-MIR-128B ucacagugaaccggucuuc
mir-142-5p 1589 1596 1a,m8 hsa-miR-142-5p CAUAAAGUAGAAAGCACUAC
miR-185 62 68 1a hsa-miR-185脑 UGGAGAGAAAGGCAGUUC
miR-19 2057 2064 1a,m8 hsa-miR-19a UGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19b ugugcaaauccaugcaaaacuga
miR-22 1451 1457 M8 hsa-miR-22脑 Aagcugccaguugaagaacugu
miR-224 213 219 M8 hsa-miR-224 caagucacuaguguguccuuua
miR-27 33 39 M8 hsa-miR-27a脑 UUCACAGUGGCUAAGUUCCGC
hsa-miR-27b脑 UUCACAGUGGCUAAGUUCUGC
miR-505 1105 1112 1a,m8 HSA-MIR-505 GUCAACACUUGCUGGUUUCCUC