Gene Page:CSE1L

Summary?
GeneID 1434
Symbol CSE1L
Synonyms CAS|CSE1|XPO2
Description CSE1 chromosome segregation 1-like (yeast)
Reference MIM:601342|HGNC:HGNC:2431|Ensembl:ENSG00000124207|HPRD:03217|Vega:OTTHUMG00000033046
Gene type protein-coding
Map location 20q13
Pascal p-value 0.001
Sherlock p-value 0.594
Fetal beta 2.028
DMG 1 (# studies)
eGene Meta
Support G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.humanNRC
CompositeSet

Gene in Data Sources
基因集名称 Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:vanEijk_2014 Genome-wide DNA methylation analysis This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 1
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0208

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg26206598 20 47445432 CSE1L 0.003 2.496 DMG:vanEijk_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene 皮尔森的公司rrelation Spearman's Correlation
RBM15B 0.97 0.97
MARCKSL1 0.96 0.92
AC004471.2 0.96 0.93
DBN1 0.96 0.95
TSSK2 0.96 0.93
KDM2B 0.96 0.95
JUP 0.95 0.92
ZNF48 0.95 0.95
SEMA4C 0.95 0.93
ZBTB12 0.95 0.94
Top 10 negatively co-expressed genes
Gene 皮尔森的公司rrelation Spearman's Correlation
C5orf53 -0.75 -0.77
AF347015.27 -0.75 -0.91
AF347015.31 -0.74 -0.90
HLA-F -0.73 -0.75
MT-CO2 -0.73 -0.90
AF347015.33 -0.72 -0.87
S100B -0.72 -0.83
AIFM3 -0.72 -0.73
ALDOC -0.71 -0.70
MT-CYB -0.71 -0.87

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005515 protein binding 新闻学会 17719542
GO:0008262 importin-alpha export receptor activity TAS 9323134
Biological process 去的术语 Evidence Neuro keywords PubMed ID
去:0000059 protein import into nucleus, docking IEA -
GO:0008283 cell proliferation TAS 7479798
GO:0006915 apoptosis TAS 7479798
GO:0006886 intracellular protein transport IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 nucleus TAS 9323134
GO:0005643 nuclear pore IEA -
GO:0005737 cytoplasm TAS 9323134

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
CDH1 Arc-1 | CD324 | CDHE | ECAD | LCAM | UVO cadherin 1, type 1, E-cadherin (epithelial) - HPRD,BioGRID 12061792
HNRNPL FLJ35509 | HNRPL | P/OKcl.14 | hnRNP-L heterogeneous nuclear ribonucleoprotein L Two-hybrid BioGRID 16169070
IKBKG AMCBX1 | FIP-3 | FIP3 | Fip3p | IKK-gamma | IP | IP1 | IP2 | IPD2 | NEMO inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma - HPRD 14743216
KPNA1 IPOA5 | NPI-1 | RCH2 | SRP1 karyopherin alpha 1 (importin alpha 5) Reconstituted Complex BioGRID 10523667
KPNA2 IPOA1 | QIP2 | RCH1 | SRP1alpha karyopherin alpha 2 (RAG cohort 1, importin alpha 1) Reconstituted Complex BioGRID 9323134|10523667
KPNA4 IPOA3 | MGC12217 | MGC26703 | QIP1 | SRP3 karyopherin alpha 4 (importin alpha 3) Reconstituted Complex BioGRID 10523667
KPNA6 FLJ11249 | IPOA7 | KPNA7 | MGC17918 karyopherin alpha 6 (importin alpha 7) - HPRD 10523667
PPP5C FLJ36922 | PP5 | PPP5 protein phosphatase 5, catalytic subunit Two-hybrid BioGRID 16169070
RAN ARA24 | Gsp1 | TC4 RAN, member RAS oncogene family - HPRD 9323134
RPL22 EAP | HBP15 | HBP15/L22 ribosomal protein L22 Two-hybrid BioGRID 16169070
STAT1 DKFZp686B04100 | ISGF-3 | STAT91 signal transducer and activator of transcription 1, 91kDa - HPRD 11927559
TMEM62 FLJ23375 transmembrane protein 62 Two-hybrid BioGRID 16169070
TNFRSF1B CD120b | TBPII | TNF-R-II | TNF-R75 | TNFBR | TNFR1B | TNFR2 | TNFR80 | p75 | p75TNFR tumor necrosis factor receptor superfamily, member 1B - HPRD 14743216
YWHAG 14-3-3GAMMA tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide - HPRD 15324660


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
ST INTEGRIN SIGNALING PATHWAY 82 62 All SZGR 2.0 genes in this pathway
PID P53 DOWNSTREAM PATHWAY 137 94 All SZGR 2.0 genes in this pathway
PID P53 REGULATION PATHWAY 59 50 All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663 425 All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY UP 430 232 All SZGR 2.0 genes in this pathway
HUMMEL BURKITTS LYMPHOMA UP 43 27 All SZGR 2.0 genes in this pathway
GRAHAM CML DIVIDING VS NORMAL QUIESCENT UP 181 101 All SZGR 2.0 genes in this pathway
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING DN 87 49 All SZGR 2.0 genes in this pathway
BIDUS METASTASIS UP 214 134 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633 376 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722 443 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS UP 293 179 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485 334 All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN 228 137 All SZGR 2.0 genes in this pathway
CHIN BREAST CANCER COPY NUMBER UP 27 18 All SZGR 2.0 genes in this pathway
VANHARANTA UTERINE FIBROID WITH 7Q DELETION UP 67 37 All SZGR 2.0 genes in this pathway
OUELLET OVARIAN CANCER INVASIVE VS LMP UP 117 85 All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP 536 340 All SZGR 2.0 genes in this pathway
MISSIAGLIA REGULATED BY METHYLATION DN 122 67 All SZGR 2.0 genes in this pathway
OUELLET CULTURED OVARIAN CANCER INVASIVE VS LMP UP 69 40 All SZGR 2.0 genes in this pathway
SEIDEN MET SIGNALING 19 16 All SZGR 2.0 genes in this pathway
SCHLOSSER MYC TARGETS AND SERUM RESPONSE DN 47 34 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358 245 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779 480 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024 594 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795 478 All SZGR 2.0 genes in this pathway
BENPORATH ES 1 379 235 All SZGR 2.0 genes in this pathway
BENPORATH PROLIFERATION 147 80 All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP 424 268 All SZGR 2.0 genes in this pathway
KENNY CTNNB1 TARGETS UP 50 30 All SZGR 2.0 genes in this pathway
BASSO B LYMPHOCYTE NETWORK 143 96 All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION DN 187 122 All SZGR 2.0 genes in this pathway
MANALO HYPOXIA DN 289 166 All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN 309 206 All SZGR 2.0 genes in this pathway
SANA RESPONSE TO IFNG DN 85 56 All SZGR 2.0 genes in this pathway
PEART HDAC PROLIFERATION CLUSTER DN 76 57 All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE DN 245 154 All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN 337 230 All SZGR 2.0 genes in this pathway
FERRANDO T ALL WITH MLL ENL FUSION DN 87 57 All SZGR 2.0 genes in this pathway
XU RESPONSE TO TRETINOIN AND NSC682994 DN 15 12 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS DN 371 218 All SZGR 2.0 genes in this pathway
ZHU CMV ALL UP 120 89 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 4 48 32 All SZGR 2.0 genes in this pathway
ZHU CMV 24 HR UP 93 65 All SZGR 2.0 genes in this pathway
LY AGING OLD DN 56 35 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D UP 210 124 All SZGR 2.0 genes in this pathway
DAIRKEE CANCER PRONE RESPONSE BPA 51 35 All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN DN 249 165 All SZGR 2.0 genes in this pathway
布卢姆的反应TO SALIRASIB DN 342 220 All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6 456 285 All SZGR 2.0 genes in this pathway
CROONQUIST NRAS SIGNALING DN 72 47 All SZGR 2.0 genes in this pathway
SAKAI CHRONIC HEPATITIS VS LIVER CANCER UP 83 63 All SZGR 2.0 genes in this pathway
KOBAYASHI EGFR SIGNALING 24HR DN 251 151 All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2 277 172 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S2 115 74 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605 377 All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE 335 193 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 11 103 68 All SZGR 2.0 genes in this pathway
ACOSTA PROLIFERATION INDEPENDENT MYC TARGETS UP 84 51 All SZGR 2.0 genes in this pathway
DN PILON KLF1目标 1972 1213 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918 550 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882 538 All SZGR 2.0 genes in this pathway
ALFANO MYC TARGETS 239 156 All SZGR 2.0 genes in this pathway
ZHOU CELL CYCLE GENES IN IR RESPONSE 24HR 128 73 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family 目标位置 miRNA ID miRNA seq
UTR start UTR end Match method
miR-137 482 488 1A hsa-miR-137 UAUUGCUUAAGAAUACGCGUAG