Gene Page:CSK

Summary?
GeneID 1445
Symbol CSK
Synonyms -
Description c-src tyrosine kinase
Reference MIM:124095|HGNC:HGNC:2444|Ensembl:ENSG00000103653|HPRD:00496|Vega:OTTHUMG00000142814
Gene type protein-coding
Map location 15q24.1
Pascal p-value 0.015
Sherlock p-value 0.374
Fetal beta -0.145

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 系统的搜索PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0102

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
UBE3A 0.97 0.97
IPO7 0.96 0.97
BCLAF1 0.96 0.97
DIS3 0.95 0.96
ZMYM2 0.95 0.96
FYTTD1 0.95 0.96
CAND1 0.95 0.97
KPNA4 0.95 0.95
SMEK2 0.95 0.95
PPP2R5E 0.95 0.96
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
FXYD1 -0.77 -0.86
MT-CO2 -0.75 -0.85
AF347015.31 -0.74 -0.83
AF347015.33 -0.73 -0.81
HIGD1B -0.73 -0.84
IFI27 -0.72 -0.83
MT-CYB -0.72 -0.81
TSC22D4 -0.71 -0.78
HSD17B14 -0.71 -0.76
AF347015.8 -0.71 -0.82

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0005524 ATP binding IEA -
GO:0004715 non-membrane spanning protein tyrosine kinase activity IEA -
GO:0016740 transferase activity IEA -
GO:0008022 protein C-terminus binding TAS 8890164
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006468 protein amino acid phosphorylation TAS 1945408
GO:0008285 negative regulation of cell proliferation IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005737 cytoplasm TAS 8890164
GO:0005911 cell-cell junction IEA -
GO:0005886 plasma membrane EXP 15574420
GO:0005886 plasma membrane 新闻学会 10790433

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ARRB1 ARB1 | ARR1 arrestin, beta 1 - HPRD,BioGRID 10753943
CAV1 CAV | MSTP085 | VIP21 caveolin 1, caveolae protein, 22kDa - HPRD,BioGRID 11805080
CBL C-CBL | CBL2 | RNF55 Cas-Br-M (murine) ecotropic retroviral transforming sequence - HPRD,BioGRID 11149930
CD247 CD3-ZETA | CD3H | CD3Q | CD3Z | T3Z | TCRZ CD247 molecule - HPRD 9172452
CD44 CDW44 | CSPG8 | ECMR-III | HCELL | IN | LHR | MC56 | MDU2 | MDU3 | MGC10468 | MIC4 | MUTCH-I | Pgp1 CD44 molecule (Indian blood group) - HPRD 11084024
CDH5 7B4 | CD144 | FLJ17376 cadherin 5, type 2 (vascular endothelium) CDH5 (VE-cadherin) interacts with CSK. BIND 15861137
CREBBP CBP | KAT3A | RSTS CREB binding protein - HPRD,BioGRID 10801129
CSK MGC117393 c-src tyrosine kinase CSK autophosphorylates. This interaction was modeled on a demonstrated interaction using CSK from an unspecified species. BIND 12588871
DAB2 DOC-2 | DOC2 | FLJ26626 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) - HPRD,BioGRID 12473651
DAG1 156DAG | A3a | AGRNR | DAG dystroglycan 1 (dystrophin-associated glycoprotein 1) Affinity Capture-Western
Reconstituted Complex		 BioGRID 11724572
DOK3 DOKL | FLJ22570 | FLJ39939 docking protein 3 - HPRD 10733577|14993273
EGFR ERBB | ERBB1 | HER1 | PIG61 | mENA epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) Affinity Capture-MS BioGRID 16729043
ERBB3 ErbB-3 | HER3 | LCCS2 | MDA-BF-1 | MGC88033 | c-erbB-3 | c-erbB3 | erbB3-S | p180-ErbB3 | p45-sErbB3 | p85-sErbB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) Affinity Capture-MS BioGRID 16729043
FYN MGC45350 | SLK | SYN FYN oncogene related to SRC, FGR, YES - HPRD,BioGRID 8262983
HNRNPK CSBP | FLJ41122 | HNRPK | TUNP heterogeneous nuclear ribonucleoprotein K - HPRD,BioGRID 12052863
IGF1R CD221 | IGFIR | JTK13 | MGC142170 | MGC142172 | MGC18216 insulin-like growth factor 1 receptor CSK interacts with IGF-IR. BIND 10026153
IGF1R CD221 | IGFIR | JTK13 | MGC142170 | MGC142172 | MGC18216 insulin-like growth factor 1 receptor - HPRD,BioGRID 10026153
INSR CD220 | HHF5 insulin receptor CSK interacts with IR. BIND 10026153
INSR CD220 | HHF5 insulin receptor - HPRD,BioGRID 10026153
PAG1 CBP | FLJ37858 | MGC138364 | PAG phosphoprotein associated with glycosphingolipid microdomains 1 - HPRD,BioGRID 10790433
PECAM1 CD31 | PECAM-1 platelet/endothelial cell adhesion molecule - HPRD,BioGRID 9624175
PLD2 - phospholipase D2 - HPRD 12697812
PTK2 FADK | FAK | FAK1 | pp125FAK PTK2 protein tyrosine kinase 2 - HPRD,BioGRID 7529872
PTPN12 PTP-PEST | PTPG1 protein tyrosine phosphatase, non-receptor type 12 - HPRD 11158295
PXN FLJ16691 paxillin - HPRD,BioGRID 7529872
RASA1 CM-AVM | CMAVM | DKFZp434N071 | GAP | PKWS | RASA | RASGAP | p120GAP | p120RASGAP RAS p21 protein activator (GTPase activating protein) 1 - HPRD,BioGRID 7544435
RGS16 A28-RGS14 | A28-RGS14P | RGS-R regulator of G-protein signaling 16 CSK phosphorylates RGS16. This interaction was modeled on a demonstrated interaction between CSK from an unspecified species and human RSG16. BIND 12588871
SDC3 N-syndecan | SDCN | SYND3 syndecan 3 - HPRD,BioGRID 9553134
SHC1 FLJ26504 | SHC | SHCA SHC (Src homology 2 domain containing) transforming protein 1 - HPRD,BioGRID 10037694|12048194
SIT1 MGC125908 | MGC125909 | MGC125910 | RP11-331F9.5 | SIT signaling threshold regulating transmembrane adaptor 1 - HPRD 11433379
SRC ASV | SRC1 | c-SRC | p60-Src v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) - HPRD,BioGRID 7513429
TGFB1I1 ARA55 | HIC-5 | HIC5 | TSC-5 transforming growth factor beta 1 induced transcript 1 Reconstituted Complex BioGRID 9858471
YTHDC1 KIAA1966 | YT521 | YT521-B YTH domain containing 1 Affinity Capture-Western
Biochemical Activity		 BioGRID 15175272


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CHEMOKINE SIGNALING PATHWAY 190 128 All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY 126 103 All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON 216 144 All SZGR 2.0 genes in this pathway
KEGG EPITHELIAL CELL SIGNALING IN HELICOBACTER PYLORI INFECTION 68 44 All SZGR 2.0 genes in this pathway
BIOCARTA CSK PATHWAY 24 20 All SZGR 2.0 genes in this pathway
BIOCARTA SRCRPTP PATHWAY 11 9 All SZGR 2.0 genes in this pathway
BIOCARTA CELL2CELL PATHWAY 14 11 All SZGR 2.0 genes in this pathway
BIOCARTA INTEGRIN PATHWAY 38 29 All SZGR 2.0 genes in this pathway
ST T CELL SIGNAL TRANSDUCTION 45 33 All SZGR 2.0 genes in this pathway
SIG BCR SIGNALING PATHWAY 46 38 All SZGR 2.0 genes in this pathway
ST B CELL ANTIGEN RECEPTOR 40 32 All SZGR 2.0 genes in this pathway
PID BCR 5PATHWAY 65 50 All SZGR 2.0 genes in this pathway
PID TCR PATHWAY 66 51 All SZGR 2.0 genes in this pathway
PID PTP1B PATHWAY 52 40 All SZGR 2.0 genes in this pathway
PID CD8 TCR PATHWAY 53 42 All SZGR 2.0 genes in this pathway
PID CXCR4 PATHWAY 102 78 All SZGR 2.0 genes in this pathway
PID PDGFRB通路 129 103 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY EGFR IN CANCER 109 80 All SZGR 2.0 genes in this pathway
REACTOME TCR SIGNALING 54 46 All SZGR 2.0 genes in this pathway
REACTOME GAB1 SIGNALOSOME 38 29 All SZGR 2.0 genes in this pathway
REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 16 15 All SZGR 2.0 genes in this pathway
REACTOME INTEGRIN CELL SURFACE INTERACTIONS 79 48 All SZGR 2.0 genes in this pathway
REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING 27 17 All SZGR 2.0 genes in this pathway
REACTOME PD1 SIGNALING 18 14 All SZGR 2.0 genes in this pathway
REACTOME COSTIMULATION BY THE CD28 FAMILY 63 48 All SZGR 2.0 genes in this pathway
REACTOME PLATELET AGGREGATION PLUG FORMATION 36 23 All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466 331 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539 350 All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 208 138 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579 346 All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS DN 310 188 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE UP 134 93 All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358 245 All SZGR 2.0 genes in this pathway
CEBALLOS TARGETS OF TP53 AND MYC DN 38 31 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP 479 299 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795 478 All SZGR 2.0 genes in this pathway
MAGRANGEAS MULTIPLE MYELOMA IGG VS IGA DN 26 16 All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE UP 157 105 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD1 AND CD2 DN 51 32 All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION NEOCORTEX UP 83 66 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
杰克逊DNMT1圆盾TS UP 77 57 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022 619 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
AMUNDSON POOR SURVIVAL AFTER GAMMA RADIATION 2G 171 96 All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN 354 216 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540 340 All SZGR 2.0 genes in this pathway
ZHAN V1 LATE DIFFERENTIATION GENES DN 15 13 All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION 368 247 All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN 253 192 All SZGR 2.0 genes in this pathway
MARTENS BOUND BY PML RARA FUSION 456 287 All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS UP 295 155 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-140 635 641 m8 hsa-miR-140brain AGUGGUUUUACCCUAUGGUAG
miR-216 303 309 m8 hsa-miR-216 UAAUCUCAGCUGGCAACUGUG
miR-24 92 98 m8 hsa-miR-24SZ UGGCUCAGUUCAGCAGGAACAG
miR-299-5p 634 640 1A hsa-miR-299-5p UGGUUUACCGUCCCACAUACAU
miR-342 616 622 1A hsa-miR-342brain UCUCACACAGAAAUCGCACCCGUC
miR-365 374 380 m8 hsa-miR-365 UAAUGCCCCUAAAAAUCCUUAU