Gene Page:CSNK1A1

Summary?
GeneID 1452
Symbol CSNK1A1
Synonyms CK1|CK1a|CKIa|HEL-S-77p|HLCDGP1|PRO2975
Description casein kinase 1 alpha 1
Reference MIM:600505|HGNC:HGNC:2451|Ensembl:ENSG00000113712|HPRD:02739|Vega:OTTHUMG00000163463
Gene type protein-coding
Map location 5q32
Pascal p-value 0.214
Sherlock p-value 0.843
Fetal beta 1.434
eGene Myers' cis & trans
Support G2Cdb.humanPSD
G2Cdb.humanPSP

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 系统搜索PubMed的genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I Genome scan meta-analysis Psr: 0.0032
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.01718
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.00459
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0752

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs4491879 chr3 189373908 CSNK1A1 1452 0.15 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SEC61A1 0.91 0.90
MTMR3 0.90 0.89
ZXDC 0.90 0.87
SEPN1 0.89 0.92
SUFU 0.89 0.87
PHF2 0.89 0.91
AMMECR1L 0.89 0.86
LIX1L 0.89 0.90
POFUT1 0.89 0.86
PATZ1 0.89 0.90
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
C5orf53 -0.71 -0.76
AF347015.27 -0.66 -0.76
S100B -0.65 -0.74
ACOT13 -0.64 -0.68
MT-CO2 -0.64 -0.78
AF347015.31 -0.64 -0.76
HLA-F -0.64 -0.66
AF347015.33 -0.63 -0.74
CA4 -0.63 -0.67
FXYD1 -0.63 -0.73

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0005524 ATP binding IEA -
GO:0004674 protein serine/threonine kinase activity IEA -
GO:0016740 transferase activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006468 protein amino acid phosphorylation TAS 10777483
GO:0016055 Wnt receptor signaling pathway IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005829 cytosol EXP 11955436|12000790|12820959
|15327769|16753179
GO:0005737 cytoplasm IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ACTA1 ACTA | ASMA | CFTD | CFTD1 | CFTDM | MPFD | NEM1 | NEM2 | NEM3 actin, alpha 1, skeletal muscle Affinity Capture-MS BioGRID 12062430
ADAP1 CENTA1 | GCS1L | p42IP4 ArfGAP with dual PH domains 1 - HPRD,BioGRID 11278595
AP3B1 ADTB3 | ADTB3A | HPS | HPS2 | PE adaptor-related protein complex 3, beta 1 subunit - HPRD 12062430
AXIN1 AXIN | MGC52315 axin 1 - HPRD,BioGRID 11884395
CHRM3 HM3 cholinergic receptor, muscarinic 3 - HPRD,BioGRID 10777483
ERF PE-2 | PE2 Ets2 repressor factor Co-purification BioGRID 12062430
HMGB1 DKFZp686A04236 | HMG1 | HMG3 | SBP-1 high-mobility group box 1 - HPRD,BioGRID 12062430
HMGB2 HMG2 high-mobility group box 2 - HPRD,BioGRID 12062430
KPNA2 IPOA1 | QIP2 | RCH1 | SRP1alpha karyopherin alpha 2 (RAG cohort 1, importin alpha 1) - HPRD,BioGRID 12062430
PPP1R14A CPI-17 | CPI17 | PPP1INL protein phosphatase 1, regulatory (inhibitor) subunit 14A - HPRD,BioGRID 12062430
PPP1R14A CPI-17 | CPI17 | PPP1INL protein phosphatase 1, regulatory (inhibitor) subunit 14A - HPRD 15003508
PPP2CA PP2Ac | PP2CA | RP-C protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform Affinity Capture-MS BioGRID 12062430
PPP2R5A B56A | MGC131915 | PR61A protein phosphatase 2, regulatory subunit B', alpha isoform - HPRD 12062430
RCC1 CHC1 | RCC1-I regulator of chromosome condensation 1 - HPRD,BioGRID 12062430
SYT9 FLJ45896 synaptotagmin IX - HPRD,BioGRID 12062430
TNFRSF1B CD120b | TBPII | TNF-R-II | TNF-R75 | TNFBR | TNFR1B | TNFR2 | TNFR80 | p75 | p75TNFR tumor necrosis factor receptor superfamily, member 1B - HPRD,BioGRID 7559483


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG WNT SIGNALING PATHWAY 151 112 All SZGR 2.0 genes in this pathway
KEGG HEDGEHOG SIGNALING PATHWAY 56 42 All SZGR 2.0 genes in this pathway
BIOCARTA P35ALZHEIMERS PATHWAY 11 9 All SZGR 2.0 genes in this pathway
BIOCARTA P53HYPOXIA PATHWAY 23 21 All SZGR 2.0 genes in this pathway
BIOCARTA NFAT PATHWAY 56 45 All SZGR 2.0 genes in this pathway
BIOCARTA WNT PATHWAY 26 24 All SZGR 2.0 genes in this pathway
WNT SIGNALING 89 71 All SZGR 2.0 genes in this pathway
ST WNT BETA CATENIN PATHWAY 34 28 All SZGR 2.0 genes in this pathway
ST FAS SIGNALING PATHWAY 65 54 All SZGR 2.0 genes in this pathway
PID WNT NONCANONICAL PATHWAY 32 26 All SZGR 2.0 genes in this pathway
PID BETA CATENIN DEG PATHWAY 18 17 All SZGR 2.0 genes in this pathway
PID PS1 PATHWAY 46 39 All SZGR 2.0 genes in this pathway
PID NFAT 3PATHWAY 54 47 All SZGR 2.0 genes in this pathway
PID FOXO PATHWAY 49 43 All SZGR 2.0 genes in this pathway
PID HEDGEHOG GLI PATHWAY 48 35 All SZGR 2.0 genes in this pathway
PID P53 REGULATION PATHWAY 59 50 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY WNT 65 41 All SZGR 2.0 genes in this pathway
REACTOME CTNNB1 PHOSPHORYLATION CASCADE 16 11 All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567 375 All SZGR 2.0 genes in this pathway
TURASHVILI BREAST DUCTAL CARCINOMA VS DUCTAL NORMAL DN 198 110 All SZGR 2.0 genes in this pathway
TURASHVILI BREAST DUCTAL CARCINOMA VS LOBULAR NORMAL DN 69 43 All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE DN 244 147 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
LAIHO COLORECTAL CANCER SERRATED UP 112 71 All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS UP 372 227 All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP 404 246 All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER ZNF217 AMPLIFIED UP 78 48 All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR DN 214 133 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633 376 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722 443 All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES SKIN DN 27 20 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485 334 All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS C UP 170 114 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358 245 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 All SZGR 2.0 genes in this pathway
里克曼肿瘤分化和管理不善的DN 382 224 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN 514 330 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT AND CANCER BOX4 DN 32 22 All SZGR 2.0 genes in this pathway
COLIN PILOCYTIC ASTROCYTOMA VS GLIOBLASTOMA DN 28 21 All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION UP 195 138 All SZGR 2.0 genes in this pathway
GALE APL WITH FLT3 MUTATED UP 56 35 All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405 264 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS UP 198 132 All SZGR 2.0 genes in this pathway
CARDOSO RESPONSE TO GAMMA RADIATION AND 3AB 18 11 All SZGR 2.0 genes in this pathway
JIANG AGING CEREBRAL CORTEX DN 54 43 All SZGR 2.0 genes in this pathway
BILD SRC ONCOGENIC SIGNATURE 62 38 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953 554 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783 442 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY GAMMA AND UV RADIATION 88 65 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN 195 135 All SZGR 2.0 genes in this pathway
FINETTI BREAST CANCERS KINOME GRAY 15 10 All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS UP 170 107 All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB UP 245 159 All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER BRCA1 DN 44 28 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504 321 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 DN 336 211 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918 550 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-135 958 964 m8 hsa-miR-135a UAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135b UAUGGCUUUUCAUUCCUAUGUG
miR-141/200a 550 556 m8 hsa-miR-141 UAACACUGUCUGGUAAAGAUGG
hsa-miR-200a UAACACUGUCUGGUAACGAUGU
miR-155 662 668 1A hsa-miR-155 UUAAUGCUAAUCGUGAUAGGGG
miR-186 1073 1079 m8 hsa-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
miR-203.1 369 375 1A hsa-miR-203 UGAAAUGUUUAGGACCACUAG
miR-30-5p 830 837 1A,m8 hsa-miR-30a-5p UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
miR-325 638 645 1A,m8 hsa-miR-325 CCUAGUAGGUGUCCAGUAAGUGU
miR-330 356 363 1A,m8 hsa-miR-330brain GCAAAGCACACGGCCUGCAGAGA
miR-409-3p 486 492 m8 hsa-miR-409-3p CGAAUGUUGCUCGGUGAACCCCU
miR-493-5p 83 89 m8 hsa-miR-493-5p UUGUACAUGGUAGGCUUUCAUU
miR-495 326 332 1A hsa-miR-495brain AAACAAACAUGGUGCACUUCUUU
miR-9 539 546 1A,m8 hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA