Gene Page:CSNK1E

Summary?
GeneID 1454
Symbol CSNK1E
Synonyms CKIepsilon|HCKIE
Description casein kinase 1 epsilon
Reference MIM:600863|HGNC:HGNC:2453|Ensembl:ENSG00000213923|HPRD:02919|Vega:OTTHUMG00000151135
Gene type protein-coding
Map location 22q13.1
Pascal p-value 0.014
Sherlock p-value 0.077
Fetal beta 0.948
DMG 1 (# studies)
eGene Hippocampus
Support G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.humanPSD
G2Cdb.humanPSP

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg04766377 22 38713606 CSNK1E 1.03E-5 0.466 0.013 DMG:Wockner_2014
cg09197891 22 38713447 CSNK1E 8.74E-5 -0.223 0.026 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
TMBIM1 0.93 0.95
CYP2J2 0.90 0.93
ALDOC 0.89 0.92
HADHB 0.88 0.90
CLU 0.88 0.92
PIR 0.87 0.88
NDRG2 0.87 0.93
SNTA1 0.87 0.90
GRAMD3 0.86 0.91
PLEKHB1 0.86 0.93
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
NKIRAS2 -0.74 -0.75
CRMP1 -0.73 -0.78
ZNF821 -0.72 -0.77
PJA1 -0.72 -0.75
DNAJC9 -0.72 -0.74
MPP3 -0.72 -0.78
TTLL1 -0.72 -0.75
ZWILCH -0.71 -0.75
PPM1G -0.71 -0.75
RTF1 -0.71 -0.79

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
AKAP9 AKAP350 | AKAP450 | CG-NAP | HYPERION | KIAA0803 | MU-RMS-40.16A | PRKA9 | YOTIAO A kinase (PRKA) anchor protein (yotiao) 9 - HPRD 12270714
ANKRD6 DIVERSIN ankyrin repeat domain 6 - HPRD,BioGRID 12183362
ARNTL BMAL1 | BMAL1c | JAP3 | MGC47515 | MOP3 | PASD3 | TIC | bHLHe5 aryl hydrocarbon receptor nuclear translocator-like - HPRD,BioGRID 11875063
AXIN1 AXIN | MGC52315 axin 1 Affinity Capture-Western
Phenotypic Suppression		 BioGRID 11884395
AXIN1 AXIN | MGC52315 axin 1 - HPRD 11487578|12000790
CRY1 PHLL1 cryptochrome 1 (photolyase-like) - HPRD 11875063
DVL1 DVL | MGC54245 dishevelled, dsh homolog 1 (Drosophila) - HPRD,BioGRID 11487578|11818547
DVL2 - dishevelled, dsh homolog 2 (Drosophila) Two-hybrid BioGRID 16189514
ESR1 DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1 estrogen receptor 1 ER interacts with CSNK1E. BIND 16009131
MCC DKFZp762O1615 | FLJ38893 | FLJ46755 | MCC1 mutated in colorectal cancers Affinity Capture-MS BioGRID 17353931
PER1 MGC88021 | PER | RIGUI | hPER period homolog 1 (Drosophila) - HPRD,BioGRID 10848614|11865049
PER3 GIG13 period homolog 3 (Drosophila) Affinity Capture-Western BioGRID 14701732
PPP1R14A CPI-17 | CPI17 | PPP1INL protein phosphatase 1, regulatory (inhibitor) subunit 14A - HPRD 15003508
RAD54B FSBP | RDH54 RAD54 homolog B (S. cerevisiae) Two-hybrid BioGRID 16189514
TP53 FLJ92943 | LFS1 | TRP53 | p53 tumor protein p53 - HPRD 9349507


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG WNT SIGNALING PATHWAY 151 112 All SZGR 2.0 genes in this pathway
KEGG HEDGEHOG SIGNALING PATHWAY 56 42 All SZGR 2.0 genes in this pathway
KEGG CIRCADIAN RHYTHM MAMMAL 13 13 All SZGR 2.0 genes in this pathway
PID BETA CATENIN DEG PATHWAY 18 17 All SZGR 2.0 genes in this pathway
PID CIRCADIAN PATHWAY 16 15 All SZGR 2.0 genes in this pathway
PID FOXO PATHWAY 49 43 All SZGR 2.0 genes in this pathway
PID HEDGEHOG GLI PATHWAY 48 35 All SZGR 2.0 genes in this pathway
PID P53 REGULATION PATHWAY 59 50 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE 421 253 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC 325 185 All SZGR 2.0 genes in this pathway
REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 66 43 All SZGR 2.0 genes in this pathway
REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES 59 38 All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G2 G2 M PHASES 81 50 All SZGR 2.0 genes in this pathway
REACTOME CIRCADIAN CLOCK 53 40 All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP 255 177 All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP 473 314 All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN 335 193 All SZGR 2.0 genes in this pathway
SER SCHLOSSER MYC目标压抑UM 159 93 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP 479 299 All SZGR 2.0 genes in this pathway
LIAO METASTASIS 539 324 All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY DN 382 224 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734 436 All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062 725 All SZGR 2.0 genes in this pathway
考夫曼DNA修复GENES 230 137 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 All SZGR 2.0 genes in this pathway
ZHANG TARGETS OF EWSR1 FLI1 FUSION 88 68 All SZGR 2.0 genes in this pathway
JAZAERI BREAST CANCER BRCA1 VS BRCA2 DN 43 31 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
《图片报》极品致癌签名 261 166 All SZGR 2.0 genes in this pathway
LEE METASTASIS AND ALTERNATIVE SPLICING UP 74 51 All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE UP 578 341 All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871 505 All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP 285 167 All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA DN 100 63 All SZGR 2.0 genes in this pathway
FIRESTEIN CTNNB1 PATHWAY AND PROLIFERATION 9 5 All SZGR 2.0 genes in this pathway
FIRESTEIN CTNNB1 PATHWAY 33 23 All SZGR 2.0 genes in this pathway
FIRESTEIN PROLIFERATION 175 125 All SZGR 2.0 genes in this pathway
CHAUHAN RESPONSE TO METHOXYESTRADIOL DN 102 65 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP 338 225 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF DN 235 144 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN 245 150 All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER DN 238 145 All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE DN 181 97 All SZGR 2.0 genes in this pathway
COULOUARN TEMPORAL TGFB1 SIGNATURE UP 109 68 All SZGR 2.0 genes in this pathway
YAMASHITA LIVER CANCER STEM CELL UP 47 38 All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422 277 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA PRONEURAL 177 132 All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 COMPLETE 227 151 All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1 467 251 All SZGR 2.0 genes in this pathway
ZWANG CLASS 3 TRANSIENTLY INDUCED BY EGF 222 159 All SZGR 2.0 genes in this pathway